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Q97VN4 (MDH_SULSO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Synonyms:sqdB
Ordered Locus Names:SSO2585
OrganismSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) [Reference proteome] [HAMAP]
Taxonomic identifier273057 [NCBI]
Taxonomic lineageArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Sequence caution

The sequence AAK42709.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Probable malate dehydrogenase
PRO_0000113493

Regions

Nucleotide binding8 – 136NAD By similarity
Nucleotide binding118 – 1203NAD By similarity

Sites

Active site1721Proton acceptor By similarity
Binding site331NAD By similarity
Binding site821Substrate By similarity
Binding site881Substrate By similarity
Binding site951NAD By similarity
Binding site1201Substrate By similarity
Binding site1481Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97VN4 [UniParc].

Last modified November 16, 2001. Version 2.
Checksum: 287C1781B4178397

FASTA30833,967
        10         20         30         40         50         60 
MVKIAFIGVG KIGQTIAYSV IFDGLASEAI LYDIVPELPE KFEHELRHAI ATRGLSTEVI 

        70         80         90        100        110        120 
GTNSLDDVTN ADIILIMAGK PRKPGMSRRD LFIDNAKIQI DLAKQLPPKN PGALYIMVAN 

       130        140        150        160        170        180 
PVDMMASVFM RFSKQFTIST GDAVETMRLR SYIAKKLKVP ANKVTGYVAG EHGEDAVVLW 

       190        200        210        220        230        240 
STVKVNGKPF EEVAKGLTKE EVENYVKSIP GEIIRVMGGT TWGPATIIKD IVRSVVFNEG 

       250        260        270        280        290        300 
RVMSIATPRT YQGEIIHISV PIVVGAEIGP SLEGVLPESD RQRLNKSVED FYRVYKENLD 


HLLQTVKQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006641 Genomic DNA. Translation: AAK42709.1. Different initiation.
PIRF90431.
RefSeqNP_343919.1. NC_002754.1.

3D structure databases

ProteinModelPortalQ97VN4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273057.SSO2585.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK42709; AAK42709; SSO2585.
GeneID1454036.
KEGGsso:SSO2585.

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213793.
KOK00024.
OMADITPFMG.
ProtClustDBCLSK883804.

Enzyme and pathway databases

BioCycSSOL273057:GCH2-2395-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_SULSO
AccessionPrimary (citable) accession number: Q97VN4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: February 19, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families