Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q97VN4

- MDH_SULSO

UniProt

Q97VN4 - MDH_SULSO

Protein

Probable malate dehydrogenase

Gene

mdh

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (16 Nov 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331NADBy similarity
    Binding sitei82 – 821SubstrateBy similarity
    Binding sitei88 – 881SubstrateBy similarity
    Binding sitei95 – 951NADBy similarity
    Binding sitei120 – 1201SubstrateBy similarity
    Binding sitei148 – 1481SubstrateBy similarity
    Active sitei172 – 1721Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi8 – 136NADBy similarity
    Nucleotide bindingi118 – 1203NADBy similarity

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSSOL273057:GCH2-2395-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable malate dehydrogenase (EC:1.1.1.37)
    Gene namesi
    Name:mdh
    Synonyms:sqdB
    Ordered Locus Names:SSO2585
    OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
    Taxonomic identifieri273057 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
    ProteomesiUP000001974: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Probable malate dehydrogenasePRO_0000113493Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273057.SSO2585.

    Structurei

    3D structure databases

    ProteinModelPortaliQ97VN4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.Curated

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000213793.
    KOiK00024.
    OMAiHVVKQHL.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q97VN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKIAFIGVG KIGQTIAYSV IFDGLASEAI LYDIVPELPE KFEHELRHAI    50
    ATRGLSTEVI GTNSLDDVTN ADIILIMAGK PRKPGMSRRD LFIDNAKIQI 100
    DLAKQLPPKN PGALYIMVAN PVDMMASVFM RFSKQFTIST GDAVETMRLR 150
    SYIAKKLKVP ANKVTGYVAG EHGEDAVVLW STVKVNGKPF EEVAKGLTKE 200
    EVENYVKSIP GEIIRVMGGT TWGPATIIKD IVRSVVFNEG RVMSIATPRT 250
    YQGEIIHISV PIVVGAEIGP SLEGVLPESD RQRLNKSVED FYRVYKENLD 300
    HLLQTVKQ 308
    Length:308
    Mass (Da):33,967
    Last modified:November 16, 2001 - v2
    Checksum:i287C1781B4178397
    GO

    Sequence cautioni

    The sequence AAK42709.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK42709.1. Different initiation.
    PIRiF90431.
    RefSeqiNP_343919.1. NC_002754.1.

    Genome annotation databases

    EnsemblBacteriaiAAK42709; AAK42709; SSO2585.
    GeneIDi1454036.
    KEGGisso:SSO2585.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006641 Genomic DNA. Translation: AAK42709.1 . Different initiation.
    PIRi F90431.
    RefSeqi NP_343919.1. NC_002754.1.

    3D structure databases

    ProteinModelPortali Q97VN4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273057.SSO2585.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK42709 ; AAK42709 ; SSO2585 .
    GeneIDi 1454036.
    KEGGi sso:SSO2585.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000213793.
    KOi K00024.
    OMAi HVVKQHL.

    Enzyme and pathway databases

    BioCyci SSOL273057:GCH2-2395-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

    Entry informationi

    Entry nameiMDH_SULSO
    AccessioniPrimary (citable) accession number: Q97VN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 16, 2001
    Last sequence update: November 16, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3