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Protein

Probable malate dehydrogenase

Gene

mdh

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331NADBy similarity
Binding sitei82 – 821SubstrateBy similarity
Binding sitei88 – 881SubstrateBy similarity
Binding sitei95 – 951NADBy similarity
Binding sitei120 – 1201SubstrateBy similarity
Binding sitei148 – 1481SubstrateBy similarity
Active sitei172 – 1721Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi8 – 136NADBy similarity
Nucleotide bindingi118 – 1203NADBy similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-2395-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Synonyms:sqdB
Ordered Locus Names:SSO2585
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
ProteomesiUP000001974 Componenti: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Probable malate dehydrogenasePRO_0000113493Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273057.SSO2585.

Structurei

3D structure databases

ProteinModelPortaliQ97VN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.Curated

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213793.
InParanoidiQ97VN4.
KOiK00024.
OMAiCDQKKMF.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97VN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKIAFIGVG KIGQTIAYSV IFDGLASEAI LYDIVPELPE KFEHELRHAI
60 70 80 90 100
ATRGLSTEVI GTNSLDDVTN ADIILIMAGK PRKPGMSRRD LFIDNAKIQI
110 120 130 140 150
DLAKQLPPKN PGALYIMVAN PVDMMASVFM RFSKQFTIST GDAVETMRLR
160 170 180 190 200
SYIAKKLKVP ANKVTGYVAG EHGEDAVVLW STVKVNGKPF EEVAKGLTKE
210 220 230 240 250
EVENYVKSIP GEIIRVMGGT TWGPATIIKD IVRSVVFNEG RVMSIATPRT
260 270 280 290 300
YQGEIIHISV PIVVGAEIGP SLEGVLPESD RQRLNKSVED FYRVYKENLD

HLLQTVKQ
Length:308
Mass (Da):33,967
Last modified:November 16, 2001 - v2
Checksum:i287C1781B4178397
GO

Sequence cautioni

The sequence AAK42709.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK42709.1. Different initiation.
PIRiF90431.
RefSeqiNP_343919.1. NC_002754.1.

Genome annotation databases

EnsemblBacteriaiAAK42709; AAK42709; SSO2585.
GeneIDi1454036.
KEGGisso:SSO2585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA. Translation: AAK42709.1. Different initiation.
PIRiF90431.
RefSeqiNP_343919.1. NC_002754.1.

3D structure databases

ProteinModelPortaliQ97VN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273057.SSO2585.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK42709; AAK42709; SSO2585.
GeneIDi1454036.
KEGGisso:SSO2585.

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213793.
InParanoidiQ97VN4.
KOiK00024.
OMAiCDQKKMF.

Enzyme and pathway databases

BioCyciSSOL273057:GCH2-2395-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Entry informationi

Entry nameiMDH_SULSO
AccessioniPrimary (citable) accession number: Q97VN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: January 7, 2015
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.