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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93ElectrophileUniRule annotation1
Active sitei141Proton acceptorUniRule annotation1
Binding sitei146Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei180Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BRENDAi5.3.1.1 6163
SABIO-RKiQ97VM8
UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:SSO2592
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903461 – 227Triosephosphate isomeraseAdd BLAST227

Interactioni

Subunit structurei

Homotetramer; dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi273057.SSO2592

Structurei

3D structure databases

ProteinModelPortaliQ97VM8
SMRiQ97VM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 11Substrate bindingUniRule annotation3
Regioni201 – 202Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01087 Archaea
COG0149 LUCA
HOGENOMiHOG000223030
InParanoidiQ97VM8
KOiK01803
OMAiIPVYAQH
OrthoDBiPOG093Z0G5K

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_A TIM_A, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035990 TIM_sf
IPR000652 Triosephosphate_isomerase
IPR022891 Triosephosphate_isomerase_arc
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
TIGRFAMsiTIGR00419 tim, 1 hit
PROSITEiView protein in PROSITE
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q97VM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPPIIIINF KAYENSFGDK AVNLGKKIEK ISKEYSVEII LSTPATMIYR
60 70 80 90 100
MSQEVDLPIY AEHVDPVPLG AFTGAILPEM VKDAGAKGTL INHSERRLRA
110 120 130 140 150
DEIDDVLKRT KKLGLKSILC VDRYELVYPF SLLKPDAILI EPPELIGTGV
160 170 180 190 200
SVSKAKPEVI TRAVDEIRKS EGIYLIAGAG ITTGEDVYKA LKLGAHGIGV
210 220
ASAVMKAKEP EKVVEDFITS ALRAISS
Length:227
Mass (Da):24,736
Last modified:October 1, 2001 - v1
Checksum:iE29AE945AE6DE987
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK42716.1
PIRiE90432
RefSeqiWP_009989304.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK42716; AAK42716; SSO2592
GeneIDi27428890
KEGGisso:SSO2592
PATRICifig|273057.12.peg.2673

Similar proteinsi

Entry informationi

Entry nameiTPIS_SULSO
AccessioniPrimary (citable) accession number: Q97VM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2001
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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