ID   Q97UX8_SACS2            Unreviewed;       666 AA.
AC   Q97UX8;
DT   01-OCT-2001, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2001, sequence version 1.
DT   27-MAR-2024, entry version 104.
DE   SubName: Full=Acetyl-CoA synthetase (Acetate-CoA ligase) (AcsA-9) {ECO:0000313|EMBL:AAK42970.1};
DE            EC=6.2.1.1 {ECO:0000313|EMBL:AAK42970.1};
GN   Name=acsA-9 {ECO:0000313|EMBL:AAK42970.1};
GN   OrderedLocusNames=SSO2863 {ECO:0000313|EMBL:AAK42970.1};
OS   Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS   (Sulfolobus solfataricus).
OC   Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Saccharolobus.
OX   NCBI_TaxID=273057 {ECO:0000313|EMBL:AAK42970.1, ECO:0000313|Proteomes:UP000001974};
RN   [1] {ECO:0000313|Proteomes:UP000001974}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2
RC   {ECO:0000313|Proteomes:UP000001974};
RX   PubMed=11427726; DOI=10.1073/pnas.141222098;
RA   She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA   Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA   Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA   Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA   Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA   Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT   "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
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DR   EMBL; AE006641; AAK42970.1; -; Genomic_DNA.
DR   PIR; C90464; C90464.
DR   RefSeq; WP_009989839.1; NC_002754.1.
DR   AlphaFoldDB; Q97UX8; -.
DR   STRING; 273057.SSO2863; -.
DR   PaxDb; 273057-SSO2863; -.
DR   EnsemblBacteria; AAK42970; AAK42970; SSO2863.
DR   GeneID; 7794571; -.
DR   KEGG; sso:SSO2863; -.
DR   PATRIC; fig|273057.12.peg.2949; -.
DR   eggNOG; arCOG04201; Archaea.
DR   HOGENOM; CLU_000022_3_6_2; -.
DR   InParanoid; Q97UX8; -.
DR   PhylomeDB; Q97UX8; -.
DR   Proteomes; UP000001974; Chromosome.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IBA:GO_Central.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0006085; P:acetyl-CoA biosynthetic process; IBA:GO_Central.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF232; ACETYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:AAK42970.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001974}.
FT   DOMAIN          28..80
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          85..481
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          542..620
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   666 AA;  75800 MW;  E2779A7118B7C2C5 CRC64;
     MSVTWALPFD QKINPKLNLN RLVSITTYKE IHSQTVKDYK QFWASVASEI DWFKPWEKTL
     DDSNPPFYKW FVGGELNASY LTVDRHVKSW RKNKVAIIWE GEPVDEKGNP KEVRKLTYYD
     LYREVNRVAY LLKEKYGLKK GDAIAIYLPM IPELPIFMLA AARIGVVFTV VFSGFSADAL
     ASRINDAEAK LLITADGGWR RGKVVDLKGI VDKALEKTPT IKDVIVVRRI GNKVNMVEGR
     DKYFDEVIKD IPQNVYVEPE RMKSEDPLYI LYTSGTTGKP KGIVHDIGGY MTLLHATMKW
     VFDIRDDDIY WCTADIGWVT GHSYIVFGPL MEGATEIMYE GALDYPQPDR WVSIIERYGI
     TILYTSPTAI RSFMKYGDNW VKAHITSTVR LMHSVGEPIN PEAWEWLWKL VGREEVPFGS
     TWWMTETGGI LISHLPGLYL VPMKPGTNGP PILGIEPDVV NEDGKQVNLE ERGYLVIKNP
     WPGMPLTIYK DPERYVKVYW SRFPGMFYVG DYAVKDKDGY FWILGRADEV IKVAGHRLGT
     YELESALIEH PAVAEAAVIG VPDPVKGEVP YAFVILRQGY TPNTQLSQEI LKTVRDKVGP
     IATIDKIFFV GKLPKTRSGK IMRRVVRAVA TRAEVGDITT LEDEASVEEI KKALEEFKAE
     FEKINK
//