Reviewed, UniProtKB/Swiss-Prot Q97UA2 (PIP_SULSO)

Names and origin

Protein names

Recommended name:
    Proline iminopeptidase
      Short name=PIP
    EC=3.4.11.5
Alternative name(s):
    Prolyl aminopeptidase
      Short name=PAP
    Tricorn protease-interacting factor F1

Gene names

Name:	pip
Ordered Locus Names:	SSO3115

Organism

Sulfolobus solfataricus [Complete proteome] [HAMAP]

Taxonomic identifier

2287 [NCBI]

Taxonomic lineage

Archaea › Crenarchaeota › Thermoprotei › Sulfolobales › Sulfolobaceae › Sulfolobus

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves H-Pro-AMC as well as a wide spectrum of amino acid substrates and several peptide substrates without a proline at the N-terminus. In conjunction with the three factors F1, F2 and F3, Tricorn degrades oligopeptides in a sequential manner, yielding free amino acids By similarity.
Catalytic activity	Release of N-terminal proline from a peptide.
Subunit structure	Part of the tricorn proteolytic complex By similarity.
Sequence similarities	Belongs to the peptidase S33 family.

Ontologies

Keywords
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Proline iminopeptidase		PRO_0000080850
Sites
	Active site	116	1	Nucleophile By similarity
	Active site	255	1	By similarity
	Active site	282	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q97UA2-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: B50DE89D0A323EC3	FASTA	310	35,961
	10 20 30 40 50 60 MSYYFITMKG YSINVEEGYK RIFGINIYYK LYRVKGSNRN LVTLHGGPGG SHDYLIPLAD 70 80 90 100 110 120 LSNYGINVLF YDQFGCGRSD DPKDTSDYTI DHGLEELEEL RKQVFGNDKI VLLGHSYGGA 130 140 150 160 170 180 LAIAYALKYQ QFLRGLIVSS GLSSVPYTVK EMRRLIEELP DKYKTIIKRY ESLGDFKNPE 190 200 210 220 230 240 YLDAVNFFYS QHLLRLKEMP EPVKRTFEYI GKRRTYEIMN GPNEFTIIGT IKDWDVTEQL 250 260 270 280 290 300 YKITVPTLIT VGKYDEVTVN VAQLIHKNIK GSRLVIFENS SHMAMWEEKD KYLEVIKEFI 310 DQVYSLNMVK

References

[1]

"The complete genome of the crenarchaeon Sulfolobus solfataricus P2." She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J., Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G., Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J., Medina N., Peng X. , Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C., Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T., Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J. Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001) [PubMed: 11427726] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35092 / DSM 1617 / JCM 11322 / P2.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006641 Genomic DNA. Translation: AAK43219.1.
PIR	D90495.
RefSeq	NP_344429.1.
3D structure databases
HSSP	HSSP built from PDB template 1MTZ based on UniProtKB P96084.
ModBase	Search...
Protein family/group databases
MEROPS	S33.005.
Genome annotation databases
GeneID	1453138.
GenomeReviews	Gene locus SSO3115 in contig AE006641_GR.
KEGG	sso:SSO3115.
NMPDR	fig|273057.1.peg.2852.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q97UA2.
OMA	ARARTIY.
Enzyme and pathway databases
BioCyc	SSOL273057:SSO3115-MON.
BRENDA	3.4.11.5. 2070.
Family and domain databases
InterPro	IPR000073. AB_hydrolase_1. IPR005945. Pept_S33_TRI_F1. IPR002410. Peptidase_S33. [Graphical view]
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF005539. Pept_S33_TRI_F1. 1 hit.
PRINTS	PR00793. PROAMNOPTASE.
TIGRFAMs	TIGR01250. pro_imino_pep_2. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PIP_SULSO

Accession

Primary (citable) accession number: Q97UA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 31, 2002
Last sequence update:	October 1, 2001
Last modified:	November 3, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)