Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q97TN4 (ALF1_CLOAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fructose-bisphosphate aldolase class 1

EC=4.1.2.13
Alternative name(s):
Fructose-bisphosphate aldolase class I
Short name=FBP aldolase
Gene names
Name:fda
Ordered Locus Names:CA_P0064
Encoded onPlasmid pSOL1
OrganismClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) [Reference proteome] [HAMAP]
Taxonomic identifier272562 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate. HAMAP-Rule MF_00729

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. HAMAP-Rule MF_00729

Sequence similarities

Belongs to the class I fructose-bisphosphate aldolase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Plasmid
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionfructose-bisphosphate aldolase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Fructose-bisphosphate aldolase class 1 HAMAP-Rule MF_00729
PRO_0000216899

Sites

Active site1761Proton acceptor By similarity
Active site2131Schiff-base intermediate with dihydroxyacetone-P By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97TN4 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 75C866B87CB11551

FASTA29533,505
        10         20         30         40         50         60 
MNETQMNRIS KDKGFIAALD QSGGSTPKAL LQYGIKENSY SNDEEMFNLV HEMRKRIIKS 

        70         80         90        100        110        120 
TAFNSKYILG AILFENTMYR TIDHKYTADY LWNEKNIVPF LKIDKGLSEL ENGVQLMKPI 

       130        140        150        160        170        180 
TNLDELLKAA IEKNIFGTKM RSFIKEANSK GIKMVVDQQF ELADKIANQG LVPIIEPEVD 

       190        200        210        220        230        240 
IKSTDKEKSE ELLKLEISKH LSDLDKETKV MLKLSIPTKD NFYSDLMKDP HVVRIVALSG 

       250        260        270        280        290 
GYSQSEANER LSRNNGLIAS FSRALSENLS IDQTDEEFNE TLSNSIKEIY EASIT 

« Hide

References

[1]"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum."
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.
J. Bacteriol. 183:4823-4838(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001438 Genomic DNA. Translation: AAK76810.1.
RefSeqNP_149228.1. NC_001988.2.

3D structure databases

ProteinModelPortalQ97TN4.
SMRQ97TN4. Positions 1-295.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272562.CA_P0064.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK76810; AAK76810; CA_P0064.
GeneID1116069.
KEGGcac:CA_P0064.
PATRIC32034012. VBICloAce74127_0064.

Phylogenomic databases

eggNOGCOG3588.
HOGENOMHOG000073502.
KOK01623.
OMAGTKMRSV.
OrthoDBEOG6M6JJT.
ProtClustDBPRK05377.

Enzyme and pathway databases

BioCycCACE272562:GJIH-3909-MONOMER.
UniPathwayUPA00109; UER00183.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00729. FBP_aldolase_1.
InterProIPR000741. Aldolase_I.
IPR013785. Aldolase_TIM.
IPR023014. FBP_aldolase_I_bac.
[Graphical view]
PfamPF00274. Glycolytic. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALF1_CLOAB
AccessionPrimary (citable) accession number: Q97TN4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways