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Q97SQ9

- GLMS_STRPN

UniProt

Q97SQ9 - GLMS_STRPN

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
glmS, SP_0266
Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source By similarity.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity
Active sitei597 – 5971For Fru-6P isomerization activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-272-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Alternative name(s):
D-fructose-6-phosphate amidotransferase
GFAT
Glucosamine-6-phosphate synthase
Hexosephosphate aminotransferase
L-glutamine--D-fructose-6-phosphate amidotransferase
Gene namesi
Name:glmS
Ordered Locus Names:SP_0266
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 602601Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotationPRO_0000135391Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi170187.SP_0266.

Structurei

3D structure databases

ProteinModelPortaliQ97SQ9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2Add
BLAST
Domaini283 – 422140SIS 1Add
BLAST
Domaini455 – 592138SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiPVTRRFM.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q97SQ9-1 [UniParc]FASTAAdd to Basket

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MCGIVGVVGN TNATDILIQG LEKLEYRGYD SAGIFVLDGA DNHLVKAVGR    50
IAELSAKTAG VEGTTGIGHT RWATHGKPTE DNAHPHRSET ERFVLVHNGV 100
IENYLEIKEE YLAGHHFKGQ TDTEIAVHLI GKFAEEEGLS VLEAFKKALH 150
IIRGSYAFAL VDSQDPEVIY VAKNKSPLLI GLGEGYNMVC SDAMAMIRET 200
NQYMEIHDQE LVIVKADSVE VQDYDGNRRE RASYTAELDL SDIGKGTYPY 250
YMLKEIDEQP TVMRKLIQAY TDEAGQVVVD PDIIKAVQDA DRIYILAAGT 300
SYHAGFASKK MLEELTDTPV ELGISSEWGY GMPLLSKKPL FIFISQSGET 350
ADSRQVLVKA NEMGIPSLTV TNVPGSTLSR EANYTMLLHA GPEIAVASTK 400
AYTAQIAALA FLAKAVGEAN GNAKAQAFDL VHELSIVAQS IESTLSEKET 450
IEVKVRELLE TTRNAFYIGR GQDYYVAMEA SLKLKEISYI QCEGFAAGEL 500
KHGTIALIEE GTPVLALLSD PVLANHTRGN IQEVAARGAK VLTIAEENVA 550
KDTDDIVLTT VHPYLSPISM VVPTQLVAYF ATLHRGLDVD KPRNLAKSVT 600
VE 602
Length:602
Mass (Da):65,634
Last modified:January 23, 2007 - v3
Checksum:i51BE6E120AB21730
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK74444.1.
PIRiC95031.
RefSeqiNP_344804.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK74444; AAK74444; SP_0266.
GeneIDi930072.
KEGGispn:SP_0266.
PATRICi19704865. VBIStrPne105772_0278.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK74444.1 .
PIRi C95031.
RefSeqi NP_344804.1. NC_003028.3.

3D structure databases

ProteinModelPortali Q97SQ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_0266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK74444 ; AAK74444 ; SP_0266 .
GeneIDi 930072.
KEGGi spn:SP_0266.
PATRICi 19704865. VBIStrPne105772_0278.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi PVTRRFM.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-272-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiGLMS_STRPN
AccessioniPrimary (citable) accession number: Q97SQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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