Reviewed, UniProtKB/Swiss-Prot Q97SH1 (MTLD_STRPN)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	SP_0397

Organism

Streptococcus pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	378 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 378	378	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170726
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q97SH1-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 55754BD825F241B4	FASTA	378	42,931
	10 20 30 40 50 60 MKHSVHFGAG NIGRGFIGEI LFKNGFHIDF VDVNNQIIHA LNEKGKYEIE IAQKGQSRIE 70 80 90 100 110 120 VTNVAGINSK EHPEQVIEAI QKTDIITTAI GPNILPFIAE LLAKGIEARR VAGNTQALDV 130 140 150 160 170 180 MACENMIGGS QFLYQEVKKY LSPEGLTFAD NYIGFPNAAV DRIVPAQSHE DSLFVVVEPF 190 200 210 220 230 240 NEWVVETKRL KNPDLRLKDV HYEEDLEPFI ERKLFSVNSG HATSAYIGAH YGAKTILEAL 250 260 270 280 290 300 QNPNIKSRIE SVLAEIRSLL IAKWNFDKKE LENYHKVIIE RLENPFIVDE VSRVARTPIR 310 320 330 340 350 360 KLGYNERFIR PIRELKELSL SYKNLLKTVG YVFDYRDVND EESIRLGELL AKQSVKDVVI 370 QVTGLDDQEL IEQIVEYI

References

[1]

"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005672 Genomic DNA. Translation: AAK74561.1.
PIR	H95045.
RefSeq	NP_344921.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	930331.
GenomeReviews	Gene locus SP_0397 in contig AE005672_GR.
KEGG	spn:SP_0397.
TIGR	SP_0397.
Phylogenomic databases
HOGENOM	Q97SH1.
OMA	Q97SH1. VDRIVPN.
Enzyme and pathway databases
BRENDA	1.1.1.17. 600.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_STRPN

Accession

Primary (citable) accession number: Q97SH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)