Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Deoxyribose-phosphate aldolase

Gene

deoC

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.UniRule annotation

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.UniRule annotation

Pathwayi: 2-deoxy-D-ribose 1-phosphate degradation

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Deoxyribose-phosphate aldolase (deoC)
This subpathway is part of the pathway 2-deoxy-D-ribose 1-phosphate degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate, the pathway 2-deoxy-D-ribose 1-phosphate degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton donor/acceptorUniRule annotation1
Active sitei151Schiff-base intermediate with acetaldehydeUniRule annotation1
Active sitei180Proton donor/acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandSchiff base

Enzyme and pathway databases

UniPathwayiUPA00002; UER00468

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxyribose-phosphate aldolaseUniRule annotation (EC:4.1.2.4UniRule annotation)
Short name:
DERAUniRule annotation
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolaseUniRule annotation
PhosphodeoxyriboaldolaseUniRule annotation
Short name:
DeoxyriboaldolaseUniRule annotation
Gene namesi
Name:deoCUniRule annotation
Ordered Locus Names:SP_0843
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000572721 – 220Deoxyribose-phosphate aldolaseAdd BLAST220

Structurei

3D structure databases

ProteinModelPortaliQ97RH2
SMRiQ97RH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105FCI Bacteria
COG0274 LUCA
HOGENOMiHOG000241645
KOiK01619
OMAiMNACIPP

Family and domain databases

CDDicd00959 DeoC, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00114 DeoC_type1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011343 DeoC
IPR002915 DeoC/FbaB/lacD_aldolase
IPR028581 DeoC_typeI
PANTHERiPTHR10889 PTHR10889, 1 hit
PTHR10889:SF1 PTHR10889:SF1, 1 hit
PfamiView protein in Pfam
PF01791 DeoC, 1 hit
PIRSFiPIRSF001357 DeoC, 1 hit
SMARTiView protein in SMART
SM01133 DeoC, 1 hit
TIGRFAMsiTIGR00126 deoC, 1 hit

Sequencei

Sequence statusi: Complete.

Q97RH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNKYIDHT LLKQDAKKKQ IDSLLSEARE YDFASVCVNP TWVEHAKKGL
60 70 80 90 100
EGTDVKVCTV VGFPLGATTS AVKAFETKEA IQNGADEIDM VINVGALKSG
110 120 130 140 150
NLALVESDIR AVVEASGDKL VKVIIEACLL TDQEKVVVCQ LAQKAGADFV
160 170 180 190 200
KTSTGFSTGG ATIADVTLMR ETVGSDMGVK AAGGARSYAD ALAFVEAGAT
210 220
RIGTSAGVAI LKGELADGDY
Length:220
Mass (Da):23,004
Last modified:October 1, 2001 - v1
Checksum:i63618A74CA89E401
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA Translation: AAK74974.1
PIRiE95097
RefSeqiWP_000773677.1, NZ_AKVY01000001.1

Genome annotation databases

EnsemblBacteriaiAAK74974; AAK74974; SP_0843
KEGGispn:SP_0843

Similar proteinsi

Entry informationi

Entry nameiDEOC_STRPN
AccessioniPrimary (citable) accession number: Q97RH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health