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Q97R94 (PROA_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase
Short name=GPR
EC=1.2.1.41
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase
Glutamyl-gamma-semialdehyde dehydrogenase
Short name=GSA dehydrogenase
Gene names
Name:proA
Ordered Locus Names:SP_0932
OrganismStreptococcus pneumoniae [Complete proteome] [HAMAP]
Taxonomic identifier1313 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. HAMAP MF_00412

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412

Subcellular location

Cytoplasm By similarity HAMAP MF_00412.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Proline biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processproline biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNADP binding

Inferred from electronic annotation. Source: InterPro

glutamate-5-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420Gamma-glutamyl phosphate reductase HAMAP MF_00412
PRO_0000189788

Sequences

Sequence LengthMass (Da)Tools
Q97R94 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: A5D96CEDE50E87A2

FASTA42045,241
        10         20         30         40         50         60 
MVSRQEQFEQ VQAVKKSINT ASEEVKNQAL LAMADHLVAA TEEILAANAL DMAAAKGKIS 

        70         80         90        100        110        120 
DVMLDRLYLD ADRIEAMARG IREVVALPDP IGEVLETSQL ENGLVITKKR VAMGVIGIIY 

       130        140        150        160        170        180 
ESRPNVTSDA AALTLKSGNA VVLRSGKDAY QTTHAIVTAL KKGLETTTIH PNVIQLVEDT 

       190        200        210        220        230        240 
SRESSYAMMK AKGYLDLLIP RGGAGLINAV VENAIVPVIE TGTGIVHVYV DKDADEDKAL 

       250        260        270        280        290        300 
SIINNAKTSR PSVCNAMEVL LVHENKAASF LPRLEQVLVA ERKEAGLEPI QFRLDSKASQ 

       310        320        330        340        350        360 
FVSGQAAETQ DFDTEFLDYV LAVKVVSSLE EAVAHIESHS THHSDAIVTE NAEAAAYFTD 

       370        380        390        400        410        420 
QVDSAAVYVN ASTRFTDGGQ FGLGCEMGIS TQKLHARGPM GLKELTSYKY VVAGDGQIRE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005672 Genomic DNA. Translation: AAK75056.1.
PIRG95107.
RefSeqNP_345416.1. NC_003028.3.

3D structure databases

ProteinModelPortalQ97R94.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTRT00000026814; EBSTRP00000025906; EBSTRG00000026814.
GeneID930885.
GenomeReviewsGene locus SP_0932 in contig AE005672_GR.
KEGGspn:SP_0932.
PATRIC19706265. VBIStrPne105772_0977.
TIGRSP_0932.

Phylogenomic databases

GeneTreeEBGT00050000027638.
HOGENOMHBG318080.
OMAHRIEAMA.
ProtClustDBPRK00197.

Enzyme and pathway databases

BioCycSPNE170187-1:SP_0932-MONOMER.

Family and domain databases

HAMAPMF_00412. ProA.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KOK00147.
PANTHERPTHR11063:SF1. GSA_DH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00407. ProA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePROA_STRPN
AccessionPrimary (citable) accession number: Q97R94
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2001
Last modified: January 25, 2012
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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