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Q97R22 (KITH_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:SP_1018
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length199 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 199199Thymidine kinase HAMAP-Rule MF_00124
PRO_0000175032

Regions

Nucleotide binding9 – 168ATP By similarity
Nucleotide binding85 – 884ATP By similarity

Sites

Active site861Proton acceptor Potential
Metal binding1431Zinc By similarity
Metal binding1461Zinc By similarity
Metal binding1801Zinc By similarity
Metal binding1831Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97R22 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 7783172FEA395E83

FASTA19922,826
        10         20         30         40         50         60 
MAQLYYRYGT MNSGKTIEIL KVAYNYEEQG KGVVIMTSAL DTRDGVGYVS SRIGMKRPAL 

        70         80         90        100        110        120 
AIEETTDIFG YIRDLPEKPY CVLVDEAQFL KRHHVYDLAR VVDELDIPVM AFGLKNDFRN 

       130        140        150        160        170        180 
ELFEGSKYLL LLADKIDEIK TICQYCKKKA TMVLRTQDGL PVYDGEQIQI GGNETYISVC 

       190 
RKHYFAPMIT SNKEQNYDN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005672 Genomic DNA. Translation: AAK75133.1.
PIRB97987.
D95117.
RefSeqNP_345493.1. NC_003028.3.

3D structure databases

ProteinModelPortalQ97R22.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING170187.SP_1018.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK75133; AAK75133; SP_1018.
GeneID931532.
KEGGspn:SP_1018.
PATRIC19706449. VBIStrPne105772_1069.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076391.
KOK00857.
OMAELKTVCH.
OrthoDBEOG69D3J2.

Enzyme and pathway databases

BioCycSPNE170187:GHGN-1023-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_STRPN
AccessionPrimary (citable) accession number: Q97R22
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families