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Q97QI2

- FTHS_STRPN

UniProt

Q97QI2 - FTHS_STRPN

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSPNE170187:GHGN-1234-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:SP_1229
    OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    Taxonomic identifieri170187 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000585: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000199387Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi170187.SP_1229.

    Structurei

    3D structure databases

    ProteinModelPortaliQ97QI2.
    SMRiQ97QI2. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q97QI2-1 [UniParc]FASTAAdd to Basket

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    MKTDIEIAQS IELKPIVDVV EKLGISYDDL ELYGKYKAKL SFDKIRAVES    50
    NPVGKLILVT AINPTPAGEG KSTLTIGLAD ALNKIGKKTM IAIREPSLGP 100
    VMGIKGGAAG GGYAQVLPME DINLHFTGDM HAITTANNAL SALIDNHLHQ 150
    GNELGIDQRR ILWKRVVDLN DRTLRHVTVG LGGPLNGIPR EDGFDITVAS 200
    EIMAILCLAT DIEDLKRRLA NIVIGYRYDR TPVSVGDLQV EGALALILKD 250
    AIKPNLVQTI YGTPAFVHGG PFANIAHGCN SVLATTTALH LADYTVTEAG 300
    FGADLGAEKF LDIKTPNLPT SPDAVVIVAT LRALKMNGGV AKDALTEENV 350
    EAVRAGFANL KRHVENIRKF GIPAVVAINE FVSDTEAEIA ALKELCASID 400
    VPVELASVWA DGAEGGVALA ETVVKTIAEN PANYKRLYDN DLSVQEKIEK 450
    IVTEIYRGSK VNFEKKAQTQ IAQIVQNGWD KLPICMAKTQ YSFSDNPNAL 500
    GAPENFEITI RELVPKLGAG FIVALTGDVM TMPGLPKRPA ALNMDVESDG 550
    TVLGLF 556
    Length:556
    Mass (Da):59,616
    Last modified:October 1, 2001 - v1
    Checksum:iF8604DA4D7C1FD05
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75335.1.
    PIRiF95142.
    RefSeqiNP_345695.1. NC_003028.3.

    Genome annotation databases

    EnsemblBacteriaiAAK75335; AAK75335; SP_1229.
    GeneIDi931743.
    KEGGispn:SP_1229.
    PATRICi19706853. VBIStrPne105772_1271.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK75335.1 .
    PIRi F95142.
    RefSeqi NP_345695.1. NC_003028.3.

    3D structure databases

    ProteinModelPortali Q97QI2.
    SMRi Q97QI2. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 170187.SP_1229.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK75335 ; AAK75335 ; SP_1229 .
    GeneIDi 931743.
    KEGGi spn:SP_1229.
    PATRICi 19706853. VBIStrPne105772_1271.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci SPNE170187:GHGN-1234-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-334 / TIGR4.

    Entry informationi

    Entry nameiFTHS_STRPN
    AccessioniPrimary (citable) accession number: Q97QI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3