Q97QE2 (PYRB_STRPN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aspartate carbamoyltransferase
EC=2.1.3.2

Alternative name(s):
Aspartate transcarbamylase
Short name=ATCase

Gene names

Name:	pyrB
Ordered Locus Names:	SP_1277

Organism

Streptococcus pneumoniae [Complete proteome] [HAMAP]

Taxonomic identifier

1313 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate. HAMAP MF_00001
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3. HAMAP MF_00001
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro aspartate carbamoyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Aspartate carbamoyltransferase HAMAP MF_00001		PRO_0000113206

Sequences

	Sequence		Length	Mass (Da)
	Q97QE2 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 2902BAF3EF2DA4E4	FASTA	307	34,690
	10 20 30 40 50 60 MSENQQALNH VVSMEDLTVD QVMKLIKRGI EFKNGAQLPY EDHPIVSNLF FEDSTRTHKS 70 80 90 100 110 120 FEVAEIKLGL ERLDFDVKTS SVNKGETLYD TILTLSALGV DVCVIRHPEV DYYRELIASP 130 140 150 160 170 180 TITTSIINGG DGSGQHPSQS LLDLMTIYEE FGHFEGLKVA IAGDLDHSRV AKSNMQILKR 190 200 210 220 230 240 LGAELFFAGP EEWRSQEFAD YGQFVTIDEI IDQVDVMMFL RVQHERHDSG AVFSKEDYHA 250 260 270 280 290 300 QHGLTQERYD RLKETAILMH PAPINRDVEI ADHLVEAPKS RIVQQMTNGV FVRMAILESV LASRNAN

References

[1]

"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005672 Genomic DNA. Translation: AAK75381.1.
PIR	D95148.
RefSeq	NP_345741.1. NC_003028.3.
3D structure databases
ProteinModelPortal	Q97QE2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTRT00000026511; EBSTRP00000025603; EBSTRG00000026511.
GeneID	931791.
GenomeReviews	Gene locus SP_1277 in contig AE005672_GR.
KEGG	spn:SP_1277.
PATRIC	19706953. VBIStrPne105772_1320.
TIGR	SP_1277.
Phylogenomic databases
GeneTree	EBGT00050000027081.
HOGENOM	HBG579429.
OMA	VGIPIIN.
ProtClustDB	PRK00856.
Enzyme and pathway databases
BioCyc	SPNE170187-1:SP_1277-MONOMER.
Family and domain databases
HAMAP	MF_00001. Asp_carb_tr. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P-bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn-bd. IPR002082. Asp_carbamoyltransf_euk. [Graphical view]
KO	K00609.
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00101. ATCASE.
SUPFAM	SSF53671. Asp/Orn_carbamoyltranf. 1 hit.
TIGRFAMs	TIGR00670. Asp_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRB_STRPN

Accession

Primary (citable) accession number: Q97QE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program