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Protein

Cytidylate kinase

Gene

cmk

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPUniRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytidylate kinaseUniRule annotation (EC:2.7.4.25UniRule annotation)
Short name:
CKUniRule annotation
Alternative name(s):
Cytidine monophosphate kinaseUniRule annotation
Short name:
CMP kinaseUniRule annotation
Gene namesi
Name:cmkUniRule annotation
Ordered Locus Names:SP_1603
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001319851 – 223Cytidylate kinaseAdd BLAST223

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02001681.

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 9Combined sources5
Helixi16 – 27Combined sources12
Beta strandi30 – 33Combined sources4
Helixi34 – 47Combined sources14
Helixi55 – 64Combined sources10
Beta strandi68 – 72Combined sources5
Turni73 – 75Combined sources3
Beta strandi76 – 81Combined sources6
Beta strandi84 – 90Combined sources7
Helixi93 – 103Combined sources11
Helixi106 – 120Combined sources15
Beta strandi125 – 128Combined sources4
Beta strandi133 – 136Combined sources4
Helixi137 – 139Combined sources3
Beta strandi141 – 147Combined sources7
Helixi150 – 163Combined sources14
Helixi170 – 184Combined sources15
Beta strandi188 – 190Combined sources3
Beta strandi199 – 202Combined sources4
Helixi208 – 222Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3TNMR-A1-223[»]
ProteinModelPortaliQ97PK6.
SMRiQ97PK6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97PK6.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
HOGENOMiHOG000242850.
KOiK00945.
OMAiVRARRRY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02224. Cytidylate_kin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97PK6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTIQIAIDG PASSGKSTVA KIIAKDFGFT YLDTGAMYRA ATYMALKNQL
60 70 80 90 100
GVEEVEALLA LLDQHPISFG RSETGDQLVF VGDVDITHPI RENEVTNHVS
110 120 130 140 150
AIAAIPQVRE KLVSLQQEIA QQGGIVMDGR DIGTVVLPQA ELKIFLVASV
160 170 180 190 200
DERAERRYKE NIAKGIETDL ETLKKEIAAR DYKDSHRETS PLKQAEDAVY
210 220
LDTTGLNIQE VVEKIKAEAE KRM
Length:223
Mass (Da):24,597
Last modified:October 1, 2001 - v1
Checksum:iEDE12AD6B4D721DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75687.1.
PIRiF95186.
RefSeqiWP_000849381.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK75687; AAK75687; SP_1603.
KEGGispn:SP_1603.
PATRICi19707633. VBIStrPne105772_1658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK75687.1.
PIRiF95186.
RefSeqiWP_000849381.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3TNMR-A1-223[»]
ProteinModelPortaliQ97PK6.
SMRiQ97PK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02001681.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK75687; AAK75687; SP_1603.
KEGGispn:SP_1603.
PATRICi19707633. VBIStrPne105772_1658.

Phylogenomic databases

eggNOGiENOG4105CAT. Bacteria.
COG0283. LUCA.
HOGENOMiHOG000242850.
KOiK00945.
OMAiVRARRRY.

Miscellaneous databases

EvolutionaryTraceiQ97PK6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00238. Cytidyl_kinase_type1. 1 hit.
InterProiIPR003136. Cytidylate_kin.
IPR011994. Cytidylate_kinase_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02224. Cytidylate_kin. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00017. cmk. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCY_STRPN
AccessioniPrimary (citable) accession number: Q97PK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.