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Q97PA3 (KGUA_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanylate kinase

EC=2.7.4.8
Alternative name(s):
GMP kinase
Gene names
Name:gmk
Ordered Locus Names:SP_1738
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP-Rule MF_00328

Catalytic activity

ATP + GMP = ADP + GDP. HAMAP-Rule MF_00328

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00328.

Sequence similarities

Belongs to the guanylate kinase family.

Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpurine nucleotide metabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

guanylate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Guanylate kinase HAMAP-Rule MF_00328
PRO_0000170618

Regions

Domain5 – 184180Guanylate kinase-like
Nucleotide binding12 – 198ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97PA3 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: FD59BBD22CE515D8

FASTA20823,686
        10         20         30         40         50         60 
MADRGLLIVF SGPSGVGKGT VRREIFESSE NQFQYSVSMT TRAQRPGEVD GVDYFFRTRE 

        70         80         90        100        110        120 
EFEELIRQGQ MLEYAEYVGN YYGTPLTYVN ETLDKGIDVF LEIEVQGALQ VKKKVPDAVF 

       130        140        150        160        170        180 
IFLTPPDLDE LQDRLVGRGT DSAEVIAQRI EKAKEEIALM REYDYAIVND QVPLAAERVK 

       190        200 
CVIEAEHFCV DRVIGHYQEM LPKSPTTR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005672 Genomic DNA. Translation: AAK75814.1.
PIRE95202.
RefSeqNP_346174.1. NC_003028.3.

3D structure databases

ProteinModelPortalQ97PA3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING170187.SP_1738.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK75814; AAK75814; SP_1738.
GeneID931096.
KEGGspn:SP_1738.
PATRIC19707927. VBIStrPne105772_1806.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0194.
HOGENOMHOG000037639.
KOK00942.
OMAILEIDFQ.
OrthoDBEOG6CP410.
ProtClustDBPRK00300.

Enzyme and pathway databases

BioCycSPNE170187:GHGN-1745-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00328. Guanylate_kinase.
InterProIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR03263. guanyl_kin. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKGUA_STRPN
AccessionPrimary (citable) accession number: Q97PA3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2001
Last modified: April 16, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families