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Q97PA3

- KGUA_STRPN

UniProt

Q97PA3 - KGUA_STRPN

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Protein

Guanylate kinase

Gene

gmk

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.UniRule annotation

Catalytic activityi

ATP + GMP = ADP + GDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 198ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. guanylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-1745-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinaseUniRule annotation (EC:2.7.4.8UniRule annotation)
Alternative name(s):
GMP kinaseUniRule annotation
Gene namesi
Name:gmkUniRule annotation
Ordered Locus Names:SP_1738
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Guanylate kinasePRO_0000170618Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_1738.

Structurei

3D structure databases

ProteinModelPortaliQ97PA3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 184180Guanylate kinase-likeUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the guanylate kinase family.UniRule annotation
Contains 1 guanylate kinase-like domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0194.
HOGENOMiHOG000037639.
KOiK00942.
OMAiMSHYNEY.
OrthoDBiEOG6CP410.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00328. Guanylate_kinase.
InterProiIPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00625. Guanylate_kin. 1 hit.
[Graphical view]
SMARTiSM00072. GuKc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR03263. guanyl_kin. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97PA3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADRGLLIVF SGPSGVGKGT VRREIFESSE NQFQYSVSMT TRAQRPGEVD
60 70 80 90 100
GVDYFFRTRE EFEELIRQGQ MLEYAEYVGN YYGTPLTYVN ETLDKGIDVF
110 120 130 140 150
LEIEVQGALQ VKKKVPDAVF IFLTPPDLDE LQDRLVGRGT DSAEVIAQRI
160 170 180 190 200
EKAKEEIALM REYDYAIVND QVPLAAERVK CVIEAEHFCV DRVIGHYQEM

LPKSPTTR
Length:208
Mass (Da):23,686
Last modified:October 1, 2001 - v1
Checksum:iFD59BBD22CE515D8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75814.1.
PIRiE95202.
RefSeqiNP_346174.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK75814; AAK75814; SP_1738.
GeneIDi931096.
KEGGispn:SP_1738.
PATRICi19707927. VBIStrPne105772_1806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005672 Genomic DNA. Translation: AAK75814.1 .
PIRi E95202.
RefSeqi NP_346174.1. NC_003028.3.

3D structure databases

ProteinModelPortali Q97PA3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_1738.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK75814 ; AAK75814 ; SP_1738 .
GeneIDi 931096.
KEGGi spn:SP_1738.
PATRICi 19707927. VBIStrPne105772_1806.

Phylogenomic databases

eggNOGi COG0194.
HOGENOMi HOG000037639.
KOi K00942.
OMAi MSHYNEY.
OrthoDBi EOG6CP410.

Enzyme and pathway databases

BioCyci SPNE170187:GHGN-1745-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_00328. Guanylate_kinase.
InterProi IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR017665. Guanylate_kinase.
IPR020590. Guanylate_kinase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00625. Guanylate_kin. 1 hit.
[Graphical view ]
SMARTi SM00072. GuKc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR03263. guanyl_kin. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiKGUA_STRPN
AccessioniPrimary (citable) accession number: Q97PA3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3