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Q97NG9 (PCP2_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pyrrolidone-carboxylate peptidase 2

EC=3.4.19.3
Alternative name(s):
5-oxoprolyl-peptidase 2
Pyroglutamyl-peptidase I 2
Short name=PGP-I 2
Short name=Pyrase 2
Gene names
Name:pcp2
Ordered Locus Names:SP_2060
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity. HAMAP-Rule MF_00417

Catalytic activity

Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. HAMAP-Rule MF_00417

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00417

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00417.

Sequence similarities

Belongs to the peptidase C15 family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

pyroglutamyl-peptidase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 214214Pyrrolidone-carboxylate peptidase 2 HAMAP-Rule MF_00417
PRO_0000184741

Sites

Active site781 By similarity
Active site1411 By similarity
Active site1651 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97NG9 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 17B0A1C4F4D1A7F8

FASTA21423,406
        10         20         30         40         50         60 
MKVLVTGFEP FGGEKGNPAL EAIKGLPAEI HGAEVRWLEV PTVFHKSAQV LEEEMNRYQP 

        70         80         90        100        110        120 
DFVLCIGQAG GRTSLTPERV TINQDDACIS DNEDNQPIDR PIRPDGASAY FSSLPIKAMV 

       130        140        150        160        170        180 
QAIKKEGLPA SVSNTAGTFV CSHLMYQALY LVEKKSPYVK AGFMHIPYMM EQVVNRPTTP 

       190        200        210 
AMSLVDIRRG IEAAIGAIIE HGDQELKLVG GETH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005672 Genomic DNA. Translation: AAK76124.1.
PIRC95241.
RefSeqNP_346484.1. NC_003028.3.

3D structure databases

ProteinModelPortalQ97NG9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING170187.SP_2060.

Protein family/group databases

MEROPSC15.001.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK76124; AAK76124; SP_2060.
GeneID931978.
KEGGspn:SP_2060.
PATRIC19708671. VBIStrPne105772_2142.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2039.
HOGENOMHOG000242641.
KOK01304.
OMANINPAWE.
OrthoDBEOG6X1124.
ProtClustDBPRK13197.

Enzyme and pathway databases

BioCycSPNE170187:GHGN-2105-MONOMER.

Family and domain databases

Gene3D3.40.630.20. 1 hit.
HAMAPMF_00417. Pyrrolid_peptidase.
InterProIPR000816. Peptidase_C15.
IPR016125. Peptidase_C15-like.
[Graphical view]
PANTHERPTHR23402. PTHR23402. 1 hit.
PfamPF01470. Peptidase_C15. 1 hit.
[Graphical view]
PIRSFPIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTSPR00706. PYROGLUPTASE.
SUPFAMSSF53182. SSF53182. 1 hit.
TIGRFAMsTIGR00504. pyro_pdase. 1 hit.
PROSITEPS01334. PYRASE_CYS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePCP2_STRPN
AccessionPrimary (citable) accession number: Q97NG9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries