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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei108NAD; via amide nitrogenUniRule annotation1
Binding sitei108SubstrateUniRule annotation1
Binding sitei143NAD; via amide nitrogenUniRule annotation1
Active sitei194Proton acceptorUniRule annotation1
Binding sitei258NADUniRule annotation1
Binding sitei284NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

UniPathwayiUPA00940.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:SP_2091
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380381 – 338Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST338

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SP_1288Q97QD12EBI-6473470,EBI-6473467

Protein-protein interaction databases

IntActiQ97NF1. 1 interactor.
STRINGi170187.SpneT_02001228.

Structurei

3D structure databases

ProteinModelPortaliQ97NF1.
SMRiQ97NF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 259Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSF. Bacteria.
COG0240. LUCA.
HOGENOMiHOG000246854.
KOiK00057.
OMAiSAQMEMS.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97NF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKQTVAVLG PGSWGTALSQ VLNDNGHEVR IWGNLPEQIN EINTHHTNKH
60 70 80 90 100
YFKDVVLDEN IIAYTDLAET LKDVDAILFV VPTKVTRLVA QQVAQTLDHK
110 120 130 140 150
VIIMHASKGL EPDSHKRLST ILEEEIPEHL RSDIVVVSGP SHAEETIVRD
160 170 180 190 200
LTLITAASKD LQTAQYVQKL FSNHYFRLYT NTDVIGVETA GALKNIIAVG
210 220 230 240 250
AGALHGLGFG DNAKAAIIAR GLAEITRLGV ALGASPLTYS GLSGVGDLIV
260 270 280 290 300
TGTSIHSRNW RAGDALGRGE SLADIEANMG MVIEGISTTR AAYELAQELG
310 320 330
VYMPITQAIY QVIYHGTNIK DAIYDIMNNE FKAENEWS
Length:338
Mass (Da):36,777
Last modified:October 1, 2001 - v1
Checksum:i5C66DA60D26D96C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK76150.1.
PIRiE95244.
RefSeqiWP_000415103.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK76150; AAK76150; SP_2091.
KEGGispn:SP_2091.
PATRICi19708767. VBIStrPne105772_2174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK76150.1.
PIRiE95244.
RefSeqiWP_000415103.1. NZ_AKVY01000001.1.

3D structure databases

ProteinModelPortaliQ97NF1.
SMRiQ97NF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ97NF1. 1 interactor.
STRINGi170187.SpneT_02001228.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK76150; AAK76150; SP_2091.
KEGGispn:SP_2091.
PATRICi19708767. VBIStrPne105772_2174.

Phylogenomic databases

eggNOGiENOG4105CSF. Bacteria.
COG0240. LUCA.
HOGENOMiHOG000246854.
KOiK00057.
OMAiSAQMEMS.

Enzyme and pathway databases

UniPathwayiUPA00940.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPiMF_00394. NAD_Glyc3P_dehydrog. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPDA_STRPN
AccessioniPrimary (citable) accession number: Q97NF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.