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Q97NE7 (DAPEL_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyldiaminopimelate deacetylase
EC=3.5.1.47
Gene names
Ordered Locus Names:SP_2096
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length376 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate By similarity. HAMAP-Rule MF_01692

Catalytic activity

N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate. HAMAP-Rule MF_01692

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3. HAMAP-Rule MF_01692

Sequence similarities

Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 376376N-acetyldiaminopimelate deacetylase HAMAP-Rule MF_01692
PRO_0000376782

Sites

Active site691 By similarity
Active site1281Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97NE7 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: EA84AB631725FAE5

FASTA37641,664
        10         20         30         40         50         60 
MLDLIQTRRD LHQIPEIGLE EFKTQAYLLD VIEKLTTGKD FVQIRTWRTG ILVYLQGSQP 

        70         80         90        100        110        120 
ERTIGWRTDI DGLPIVEQTG LPFASQHQGR MHACVHDFHM TIALGCLERA LEEQPKNNLL 

       130        140        150        160        170        180 
FLFQPAEENE AGGMLMYEDG AFGDWLPDQF YGLHVRPDLK VGQIATNTHT LFAGTCEVKI 

       190        200        210        220        230        240 
RFKGKGGHAA FPHEANDALV AASYFVTQVQ SVVSRNVNPI EGAVVTFGVF QAGTTNNVIT 

       250        260        270        280        290        300 
DTAFLHGTIR ALTQDMSLLV QKRVKTVAEG VAAAFDMEVE VELKQGGYLP VENNPALARE 

       310        320        330        340        350        360 
LMDFFDEKDG IELIDIEPAM TGEDFGYLLS KVDGVMFWLG IDSPYALHHP QMSPKEEVLA 

       370 
IGVAAVSSFL KKKAAE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005672 Genomic DNA. Translation: AAK76155.1.
PIRB95245.
RefSeqNP_346515.1. NC_003028.3.

3D structure databases

HSSPHSSP built from PDB template 1YSJ based on UniProtKB P54955.
ProteinModelPortalQ97NE7.
ModBaseSearch...

Protein-protein interaction databases

STRING170187.SP_2096.

Protein family/group databases

MEROPSM20.A27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK76155; AAK76155; SP_2096.
GeneID930247.
KEGGspn:SP_2096.
PATRIC19708779. VBIStrPne105772_2180.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1473.
HOGENOMHOG000241404.
KOK05823.
OMALANGIAQ.
ProtClustDBCLSK876719.

Enzyme and pathway databases

UniPathwayUPA00034; UER00024.

Family and domain databases

HAMAPMF_01692. DapEL.
InterProIPR023905. AcetylDAP_deacetylase.
IPR017439. Amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFPIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAMSSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMsTIGR01891. amidohydrolases. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. False negative.
PS00759. ARGE_DAPE_CPG2_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPEL_STRPN
AccessionPrimary (citable) accession number: Q97NE7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: October 1, 2001
Last modified: May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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