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Q97N97

- FUCI_STRPN

UniProt

Q97N97 - FUCI_STRPN

Protein

L-fucose isomerase

Gene

fucI

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

    Catalytic activityi

    L-fucopyranose = L-fuculose.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei335 – 3351Proton acceptorUniRule annotation
    Metal bindingi335 – 3351ManganeseUniRule annotation
    Active sitei359 – 3591Proton acceptorUniRule annotation
    Metal bindingi359 – 3591ManganeseUniRule annotation
    Metal bindingi525 – 5251ManganeseUniRule annotation

    GO - Molecular functioni

    1. L-fucose isomerase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-fucose catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism, Fucose metabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciSPNE170187:GHGN-2218-MONOMER.
    UniPathwayiUPA00563; UER00624.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
    Alternative name(s):
    6-deoxy-L-galactose isomeraseUniRule annotation
    FucIase
    Gene namesi
    Name:fucIUniRule annotation
    Ordered Locus Names:SP_2158
    OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
    Taxonomic identifieri170187 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000000585: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 588588L-fucose isomerasePRO_0000204152Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi170187.SP_2158.

    Structurei

    Secondary structure

    1
    588
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 127
    Turni17 – 193
    Helixi20 – 4223
    Beta strandi53 – 553
    Beta strandi60 – 623
    Helixi63 – 7412
    Turni75 – 773
    Beta strandi78 – 8710
    Helixi91 – 944
    Beta strandi99 – 1013
    Beta strandi103 – 1075
    Beta strandi111 – 1133
    Helixi115 – 12915
    Beta strandi134 – 1363
    Helixi151 – 17020
    Beta strandi174 – 1807
    Helixi186 – 1883
    Helixi192 – 1998
    Beta strandi202 – 2065
    Helixi209 – 2168
    Helixi222 – 23514
    Helixi245 – 2473
    Helixi251 – 27323
    Helixi276 – 2805
    Helixi286 – 2883
    Beta strandi292 – 2976
    Turni300 – 3067
    Helixi311 – 3188
    Beta strandi319 – 3224
    Beta strandi331 – 3344
    Helixi338 – 35114
    Beta strandi356 – 3649
    Helixi366 – 3738
    Helixi379 – 3813
    Beta strandi385 – 3884
    Helixi396 – 3994
    Beta strandi402 – 4043
    Beta strandi407 – 4093
    Helixi413 – 4153
    Helixi418 – 4269
    Turni435 – 4373
    Beta strandi454 – 46310
    Turni464 – 4663
    Beta strandi467 – 47711
    Helixi482 – 4909
    Beta strandi498 – 5036
    Helixi514 – 5196
    Beta strandi523 – 5319
    Helixi534 – 54411
    Beta strandi548 – 5503
    Helixi555 – 5573
    Helixi562 – 5676
    Helixi572 – 58312

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4C20X-ray2.41A/B2-588[»]
    4C21X-ray2.55A/B1-588[»]
    4C22X-ray2.70A/B2-588[»]
    ProteinModelPortaliQ97N97.
    SMRiQ97N97. Positions 2-588.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-fucose isomerase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2407.
    HOGENOMiHOG000249674.
    KOiK01818.
    OMAiKEGQDYR.
    OrthoDBiEOG6FJNCF.

    Family and domain databases

    Gene3Di3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPiMF_01254. Fucose_iso.
    InterProiIPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view]
    PfamiPF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view]
    SUPFAMiSSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsiTIGR01089. fucI. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q97N97-1 [UniParc]FASTAAdd to Basket

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    MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP    50
    VECVISPSTI GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD 100
    IPHAIWGFNG TERPGAVYLA AVLASHAQKG IPAFGIYGRD VQEASDTDIP 150
    EDVKEKLLRY ARAALATGLM RDTAYLSMGS VSMGIGGSIV NPDFFQEYLG 200
    MRNESVDMTE FTRRMDRGIY DPEEFERALK WVKENVKEGF DHNREDLVLS 250
    REEKDRQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ 300
    RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL 350
    TNTPQIFADV RTYWSPEAVK RVTGHTLEGR AAAGFLHLIN SGSCTLDGTG 400
    QATRDGKPIM KPFWELEESE VQAMLENTDF PPANREYFRG GGFSTRFLTK 450
    GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL PEDVHHTLDN RTDPGWPTTW 500
    FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL ASMLRIPVNM 550
    HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK 588
    Length:588
    Mass (Da):65,895
    Last modified:October 1, 2001 - v1
    Checksum:i06E678EDF801786A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK76212.1.
    PIRiC95252.
    RefSeqiNP_346572.1. NC_003028.3.

    Genome annotation databases

    EnsemblBacteriaiAAK76212; AAK76212; SP_2158.
    GeneIDi930204.
    KEGGispn:SP_2158.
    PATRICi19708921. VBIStrPne105772_2252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005672 Genomic DNA. Translation: AAK76212.1 .
    PIRi C95252.
    RefSeqi NP_346572.1. NC_003028.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4C20 X-ray 2.41 A/B 2-588 [» ]
    4C21 X-ray 2.55 A/B 1-588 [» ]
    4C22 X-ray 2.70 A/B 2-588 [» ]
    ProteinModelPortali Q97N97.
    SMRi Q97N97. Positions 2-588.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 170187.SP_2158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK76212 ; AAK76212 ; SP_2158 .
    GeneIDi 930204.
    KEGGi spn:SP_2158.
    PATRICi 19708921. VBIStrPne105772_2252.

    Phylogenomic databases

    eggNOGi COG2407.
    HOGENOMi HOG000249674.
    KOi K01818.
    OMAi KEGQDYR.
    OrthoDBi EOG6FJNCF.

    Enzyme and pathway databases

    UniPathwayi UPA00563 ; UER00624 .
    BioCyci SPNE170187:GHGN-2218-MONOMER.

    Family and domain databases

    Gene3Di 3.20.14.10. 1 hit.
    3.40.275.10. 1 hit.
    3.40.50.1070. 1 hit.
    HAMAPi MF_01254. Fucose_iso.
    InterProi IPR004216. Fuc/Ara_isomerase_C.
    IPR015888. Fuc_isomerase_C.
    IPR012888. Fucose_iso_N1.
    IPR005763. Fucose_isomerase.
    IPR009015. Fucose_isomerase_N/cen.
    IPR012889. Fucose_isomerase_N2.
    [Graphical view ]
    Pfami PF02952. Fucose_iso_C. 1 hit.
    PF07881. Fucose_iso_N1. 1 hit.
    PF07882. Fucose_iso_N2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50443. SSF50443. 1 hit.
    SSF53743. SSF53743. 1 hit.
    TIGRFAMsi TIGR01089. fucI. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-334 / TIGR4.

    Entry informationi

    Entry nameiFUCI_STRPN
    AccessioniPrimary (citable) accession number: Q97N97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3