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Protein

L-fucose isomerase

Gene

fucI

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi: L-fucose degradation

This protein is involved in step 1 of the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. L-fucose isomerase (fucI)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
This subpathway is part of the pathway L-fucose degradation, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-lactaldehyde and glycerone phosphate from L-fucose, the pathway L-fucose degradation and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei335Proton acceptorUniRule annotation1
Metal bindingi335ManganeseUniRule annotation1
Active sitei359Proton acceptorUniRule annotation1
Metal bindingi359ManganeseUniRule annotation1
Metal bindingi525ManganeseUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:SP_2158
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000000585 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002041521 – 588L-fucose isomeraseAdd BLAST588

Interactioni

Protein-protein interaction databases

STRINGi170187.SpneT_02000539.

Structurei

Secondary structure

1588
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Turni17 – 19Combined sources3
Helixi20 – 42Combined sources23
Beta strandi53 – 55Combined sources3
Beta strandi60 – 62Combined sources3
Helixi63 – 74Combined sources12
Turni75 – 77Combined sources3
Beta strandi78 – 87Combined sources10
Helixi91 – 94Combined sources4
Beta strandi99 – 101Combined sources3
Beta strandi103 – 107Combined sources5
Beta strandi111 – 113Combined sources3
Helixi115 – 129Combined sources15
Beta strandi134 – 136Combined sources3
Helixi151 – 170Combined sources20
Beta strandi174 – 180Combined sources7
Helixi186 – 188Combined sources3
Helixi192 – 199Combined sources8
Beta strandi202 – 206Combined sources5
Helixi209 – 216Combined sources8
Helixi222 – 235Combined sources14
Helixi245 – 247Combined sources3
Helixi251 – 273Combined sources23
Helixi276 – 280Combined sources5
Helixi286 – 288Combined sources3
Beta strandi292 – 297Combined sources6
Turni300 – 306Combined sources7
Helixi311 – 318Combined sources8
Beta strandi319 – 322Combined sources4
Beta strandi331 – 334Combined sources4
Helixi338 – 351Combined sources14
Beta strandi356 – 364Combined sources9
Helixi366 – 373Combined sources8
Helixi379 – 381Combined sources3
Beta strandi385 – 388Combined sources4
Helixi396 – 399Combined sources4
Beta strandi402 – 404Combined sources3
Beta strandi407 – 409Combined sources3
Helixi413 – 415Combined sources3
Helixi418 – 426Combined sources9
Turni435 – 437Combined sources3
Beta strandi454 – 463Combined sources10
Turni464 – 466Combined sources3
Beta strandi467 – 477Combined sources11
Helixi482 – 490Combined sources9
Beta strandi498 – 503Combined sources6
Helixi514 – 519Combined sources6
Beta strandi523 – 531Combined sources9
Helixi534 – 544Combined sources11
Beta strandi548 – 550Combined sources3
Helixi555 – 557Combined sources3
Helixi562 – 567Combined sources6
Helixi572 – 583Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C20X-ray2.41A/B2-588[»]
4C21X-ray2.55A/B1-588[»]
4C22X-ray2.70A/B2-588[»]
ProteinModelPortaliQ97N97.
SMRiQ97N97.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EHF. Bacteria.
COG2407. LUCA.
HOGENOMiHOG000249674.
KOiK01818.
OMAiGAISYGH.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso. 1 hit.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97N97-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP
60 70 80 90 100
VECVISPSTI GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD
110 120 130 140 150
IPHAIWGFNG TERPGAVYLA AVLASHAQKG IPAFGIYGRD VQEASDTDIP
160 170 180 190 200
EDVKEKLLRY ARAALATGLM RDTAYLSMGS VSMGIGGSIV NPDFFQEYLG
210 220 230 240 250
MRNESVDMTE FTRRMDRGIY DPEEFERALK WVKENVKEGF DHNREDLVLS
260 270 280 290 300
REEKDRQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ
310 320 330 340 350
RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL
360 370 380 390 400
TNTPQIFADV RTYWSPEAVK RVTGHTLEGR AAAGFLHLIN SGSCTLDGTG
410 420 430 440 450
QATRDGKPIM KPFWELEESE VQAMLENTDF PPANREYFRG GGFSTRFLTK
460 470 480 490 500
GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL PEDVHHTLDN RTDPGWPTTW
510 520 530 540 550
FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL ASMLRIPVNM
560 570 580
HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK
Length:588
Mass (Da):65,895
Last modified:October 1, 2001 - v1
Checksum:i06E678EDF801786A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK76212.1.
PIRiC95252.
RefSeqiWP_000614266.1. NZ_AKVY01000001.1.

Genome annotation databases

EnsemblBacteriaiAAK76212; AAK76212; SP_2158.
KEGGispn:SP_2158.
PATRICi19708921. VBIStrPne105772_2252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK76212.1.
PIRiC95252.
RefSeqiWP_000614266.1. NZ_AKVY01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C20X-ray2.41A/B2-588[»]
4C21X-ray2.55A/B1-588[»]
4C22X-ray2.70A/B2-588[»]
ProteinModelPortaliQ97N97.
SMRiQ97N97.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi170187.SpneT_02000539.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK76212; AAK76212; SP_2158.
KEGGispn:SP_2158.
PATRICi19708921. VBIStrPne105772_2252.

Phylogenomic databases

eggNOGiENOG4105EHF. Bacteria.
COG2407. LUCA.
HOGENOMiHOG000249674.
KOiK01818.
OMAiGAISYGH.

Enzyme and pathway databases

UniPathwayiUPA00563; UER00624.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso. 1 hit.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiFUCI_STRPN
AccessioniPrimary (citable) accession number: Q97N97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.