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Q97N97

- FUCI_STRPN

UniProt

Q97N97 - FUCI_STRPN

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Protein

L-fucose isomerase

Gene

fucI

Organism
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Converts the aldose L-fucose into the corresponding ketose L-fuculose.UniRule annotation

Catalytic activityi

L-fucopyranose = L-fuculose.UniRule annotation

Cofactori

Mn2+UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei335 – 3351Proton acceptorUniRule annotation
Metal bindingi335 – 3351ManganeseUniRule annotation
Active sitei359 – 3591Proton acceptorUniRule annotation
Metal bindingi359 – 3591ManganeseUniRule annotation
Metal bindingi525 – 5251ManganeseUniRule annotation

GO - Molecular functioni

  1. L-fucose isomerase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. L-fucose catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Fucose metabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciSPNE170187:GHGN-2218-MONOMER.
UniPathwayiUPA00563; UER00624.

Names & Taxonomyi

Protein namesi
Recommended name:
L-fucose isomeraseUniRule annotation (EC:5.3.1.25UniRule annotation)
Alternative name(s):
6-deoxy-L-galactose isomeraseUniRule annotation
FucIase
Gene namesi
Name:fucIUniRule annotation
Ordered Locus Names:SP_2158
OrganismiStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Taxonomic identifieri170187 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000000585: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588L-fucose isomerasePRO_0000204152Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi170187.SP_2158.

Structurei

Secondary structure

1
588
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 127Combined sources
Turni17 – 193Combined sources
Helixi20 – 4223Combined sources
Beta strandi53 – 553Combined sources
Beta strandi60 – 623Combined sources
Helixi63 – 7412Combined sources
Turni75 – 773Combined sources
Beta strandi78 – 8710Combined sources
Helixi91 – 944Combined sources
Beta strandi99 – 1013Combined sources
Beta strandi103 – 1075Combined sources
Beta strandi111 – 1133Combined sources
Helixi115 – 12915Combined sources
Beta strandi134 – 1363Combined sources
Helixi151 – 17020Combined sources
Beta strandi174 – 1807Combined sources
Helixi186 – 1883Combined sources
Helixi192 – 1998Combined sources
Beta strandi202 – 2065Combined sources
Helixi209 – 2168Combined sources
Helixi222 – 23514Combined sources
Helixi245 – 2473Combined sources
Helixi251 – 27323Combined sources
Helixi276 – 2805Combined sources
Helixi286 – 2883Combined sources
Beta strandi292 – 2976Combined sources
Turni300 – 3067Combined sources
Helixi311 – 3188Combined sources
Beta strandi319 – 3224Combined sources
Beta strandi331 – 3344Combined sources
Helixi338 – 35114Combined sources
Beta strandi356 – 3649Combined sources
Helixi366 – 3738Combined sources
Helixi379 – 3813Combined sources
Beta strandi385 – 3884Combined sources
Helixi396 – 3994Combined sources
Beta strandi402 – 4043Combined sources
Beta strandi407 – 4093Combined sources
Helixi413 – 4153Combined sources
Helixi418 – 4269Combined sources
Turni435 – 4373Combined sources
Beta strandi454 – 46310Combined sources
Turni464 – 4663Combined sources
Beta strandi467 – 47711Combined sources
Helixi482 – 4909Combined sources
Beta strandi498 – 5036Combined sources
Helixi514 – 5196Combined sources
Beta strandi523 – 5319Combined sources
Helixi534 – 54411Combined sources
Beta strandi548 – 5503Combined sources
Helixi555 – 5573Combined sources
Helixi562 – 5676Combined sources
Helixi572 – 58312Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4C20X-ray2.41A/B2-588[»]
4C21X-ray2.55A/B1-588[»]
4C22X-ray2.70A/B2-588[»]
ProteinModelPortaliQ97N97.
SMRiQ97N97. Positions 2-588.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L-fucose isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2407.
HOGENOMiHOG000249674.
KOiK01818.
OMAiKEGQDYR.
OrthoDBiEOG6FJNCF.

Family and domain databases

Gene3Di3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPiMF_01254. Fucose_iso.
InterProiIPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view]
PfamiPF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view]
SUPFAMiSSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsiTIGR01089. fucI. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97N97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIQHPRIGIR PTIDGRRQGV RESLEVQTMN MAKSVADLIS STLKYPDGEP
60 70 80 90 100
VECVISPSTI GRVPEAAASH ELFKKSNVCA TITVTPCWCY GSETMDMSPD
110 120 130 140 150
IPHAIWGFNG TERPGAVYLA AVLASHAQKG IPAFGIYGRD VQEASDTDIP
160 170 180 190 200
EDVKEKLLRY ARAALATGLM RDTAYLSMGS VSMGIGGSIV NPDFFQEYLG
210 220 230 240 250
MRNESVDMTE FTRRMDRGIY DPEEFERALK WVKENVKEGF DHNREDLVLS
260 270 280 290 300
REEKDRQWEF VIKMFMIGRD LMVGNPRLAE LGFEEEAVGH HALVAGFQGQ
310 320 330 340 350
RQWTDHFPNG DFMETFLNTQ FDWNGIRKPF VFATENDSLN GVSMLFNYLL
360 370 380 390 400
TNTPQIFADV RTYWSPEAVK RVTGHTLEGR AAAGFLHLIN SGSCTLDGTG
410 420 430 440 450
QATRDGKPIM KPFWELEESE VQAMLENTDF PPANREYFRG GGFSTRFLTK
460 470 480 490 500
GDMPVTMVRL NLLKGVGPVL QIAEGYTLEL PEDVHHTLDN RTDPGWPTTW
510 520 530 540 550
FAPRLTGKGA FKSVYDVMNN WGANHGAITY GHIGADLITL ASMLRIPVNM
560 570 580
HNVPEEDIFR PKNWSLFGTE DLESADYRAC QLLGPLHK
Length:588
Mass (Da):65,895
Last modified:October 1, 2001 - v1
Checksum:i06E678EDF801786A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK76212.1.
PIRiC95252.
RefSeqiNP_346572.1. NC_003028.3.

Genome annotation databases

EnsemblBacteriaiAAK76212; AAK76212; SP_2158.
GeneIDi930204.
KEGGispn:SP_2158.
PATRICi19708921. VBIStrPne105772_2252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005672 Genomic DNA. Translation: AAK76212.1 .
PIRi C95252.
RefSeqi NP_346572.1. NC_003028.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4C20 X-ray 2.41 A/B 2-588 [» ]
4C21 X-ray 2.55 A/B 1-588 [» ]
4C22 X-ray 2.70 A/B 2-588 [» ]
ProteinModelPortali Q97N97.
SMRi Q97N97. Positions 2-588.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 170187.SP_2158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK76212 ; AAK76212 ; SP_2158 .
GeneIDi 930204.
KEGGi spn:SP_2158.
PATRICi 19708921. VBIStrPne105772_2252.

Phylogenomic databases

eggNOGi COG2407.
HOGENOMi HOG000249674.
KOi K01818.
OMAi KEGQDYR.
OrthoDBi EOG6FJNCF.

Enzyme and pathway databases

UniPathwayi UPA00563 ; UER00624 .
BioCyci SPNE170187:GHGN-2218-MONOMER.

Family and domain databases

Gene3Di 3.20.14.10. 1 hit.
3.40.275.10. 1 hit.
3.40.50.1070. 1 hit.
HAMAPi MF_01254. Fucose_iso.
InterProi IPR004216. Fuc/Ara_isomerase_C.
IPR015888. Fuc_isomerase_C.
IPR012888. Fucose_iso_N1.
IPR005763. Fucose_isomerase.
IPR009015. Fucose_isomerase_N/cen.
IPR012889. Fucose_isomerase_N2.
[Graphical view ]
Pfami PF02952. Fucose_iso_C. 1 hit.
PF07881. Fucose_iso_N1. 1 hit.
PF07882. Fucose_iso_N2. 1 hit.
[Graphical view ]
SUPFAMi SSF50443. SSF50443. 1 hit.
SSF53743. SSF53743. 1 hit.
TIGRFAMsi TIGR01089. fucI. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-334 / TIGR4.

Entry informationi

Entry nameiFUCI_STRPN
AccessioniPrimary (citable) accession number: Q97N97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3