Q97N96 (Q97N96_STRPN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Fucolectin-related protein EMBL AAK76213.1

Gene names

Ordered Locus Names:

SP_2159

Organism

Streptococcus pneumoniae TIGR4 [Complete proteome] EMBL AAK76213.1

Taxonomic identifier

170187 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	1038 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Ligand	Calcium PDB 2J1V PDB 2J1U PDB 2J1R PDB 2J1S PDB 2J1T PDB 2J22 Metal-binding PDB 2J1V PDB 2J1U PDB 2J1R PDB 2J1S PDB 2J1T PDB 2J22
Technical term	3D-structure PDB 2WMG PDB 2WMH PDB 2J1V PDB 2J1U PDB 2J1R PDB 2J1S PDB 2J1T PDB 2J22 PDB 2WMF Complete proteome
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: InterPro
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	160 – 161	2	N-acetyl-D-glucosamine binding PDB 2WMG
	Region	679 – 682	4	Fucose binding PDB 2J1V PDB 2J1U
Sites
	Metal binding	631	1	Calcium 1; via carbonyl oxygen PDB 2J1V PDB 2J1U PDB 2J1R PDB 2J1S PDB 2J1T
	Metal binding	634	1	Calcium 1 PDB 2J1V PDB 2J1U PDB 2J1R PDB 2J1S PDB 2J1T
	Metal binding	636	1	Calcium 1; via carbonyl oxygen PDB 2J1V PDB 2J1U PDB 2J1R PDB 2J1S PDB 2J1T
	Metal binding	645	1	Calcium 1 PDB 2J1V PDB 2J1U PDB 2J1R PDB 2J1S PDB 2J1T
	Metal binding	737	1	Calcium 1; via carbonyl oxygen PDB 2J1V PDB 2J1U PDB 2J1R PDB 2J1S PDB 2J1T
	Metal binding	738	1	Calcium 1 PDB 2J1V PDB 2J1U PDB 2J1R PDB 2J1S PDB 2J1T
	Metal binding	924	1	Calcium 2; via carbonyl oxygen PDB 2J22
	Metal binding	927	1	Calcium 2 PDB 2J22
	Metal binding	929	1	Calcium 2; via carbonyl oxygen PDB 2J22
	Metal binding	938	1	Calcium 2 PDB 2J22
	Metal binding	1030	1	Calcium 2; via carbonyl oxygen PDB 2J22
	Metal binding	1031	1	Calcium 2 PDB 2J22
	Binding site	53	1	Fucose PDB 2WMH
	Binding site	87	1	Fucose PDB 2WMG PDB 2WMH
	Binding site	96	1	Fucose; via carbonyl oxygen PDB 2WMG
	Binding site	129	1	Fucose PDB 2WMG PDB 2WMH
	Binding site	158	1	Galactose PDB 2WMH
	Binding site	253	1	Galactose PDB 2WMG
	Binding site	257	1	Galactose PDB 2WMG PDB 2WMH
	Binding site	301	1	Fucose PDB 2WMG PDB 2WMH
	Binding site	512	1	Fucose PDB 2WMG
	Binding site	642	1	N-acetyl-D-glucosamine PDB 2J1V
	Binding site	648	1	Fucose PDB 2J1V PDB 2J1U
	Binding site	675	1	Fucose PDB 2J1V PDB 2J1U

Sequences

	Sequence		Length	Mass (Da)
	Q97N96 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 83E593883D8AEA59	FASTA	1,038	117,744
	10 20 30 40 50 60 MNKEKIKRKL ITILFVCIGM LCFGLLAGVK ADNRVQMRTT INNESPLLLS PLYGNDNGNG 70 80 90 100 110 120 LWWGNTLKGA WEAIPEDVKP YAAIELHPAK VCKPTSCIPR DTKELREWYV KMLEEAQSLN 130 140 150 160 170 180 IPVFLVIMSA GERNTVPPEW LDEQFQKYSV LKGVLNIENY WIYNNQLAPH SAKYLEVCAK 190 200 210 220 230 240 YGAHFIWHDH EKWFWETIMN DPTFFEASQK YHKNLVLATK NTPIRDDAGT DSIVSGFWLS 250 260 270 280 290 300 GLCDNWGSST DTWKWWEKHY TNTFETGRAR DMRSYASEPE SMIAMEMMNV YTGGGTVYNF 310 320 330 340 350 360 ECAAYTFMTN DVPTPAFTKG IIPFFRHAIQ NPAPSKEEVV NRTKAVFWNG EGRISSLNGF 370 380 390 400 410 420 YQGLYSNDET MPLYNNGRYH ILPVIHEKID KEKISSIFPN AKILTKNSEE LSSKVNYLNS 430 440 450 460 470 480 LYPKLYEGDG YAQRVGNSWY IYNSNANINK NQQVMLPMYT NNTKSLSLDL TPHTYAVVKE 490 500 510 520 530 540 NPNNLHILLN NYRTDKTAMW ALSGNFDASK SWKKEELELA NWISKNYSIN PVDNDFRTTT 550 560 570 580 590 600 LTLKGHTGHK PQINISGDKN HYTYTENWDE NTHVYTITVN HNGMVEMSIN TEGTGPVSFP 610 620 630 640 650 660 TPDKFNDGNL NIAYAKPTTQ SSVDYNGDPN RAVDGNRNGN FNSGSVTHTR ADNPSWWEVD 670 680 690 700 710 720 LKKMDKVGLV KIYNRTDAET QRLSNFDVIL YDNNRNEVAK KHVNNLSGES VSLDFKEKGA 730 740 750 760 770 780 RYIKVKLLTS GVPLSLAEVE VFRESDGKQS EEDIDKITED KVVSTNKVAT QSSTNYEGVA 790 800 810 820 830 840 ALAVDGNKDG DYGHHSVTHT KADSNAWWQV DLGEEFTVSK VDIYNRTDAE PQRLSNFDVI 850 860 870 880 890 900 FLSSSGEEVF RRHFDKVVDG LLSLKVPSVG AKLVKIELKS AAIPLSLAEV EVYGSKRTPK 910 920 930 940 950 960 KLSNIALTKE TRQSSTDYNG FSRLAVDGNK NGDYGHHSVT HTKEDSPSWW EIDLAQTEEL 970 980 990 1000 1010 1020 EKLIIYNRTD AEIQRLSNFD IIIYDSNDYE VFTQHIDSLE SNNLSIDLKG LKGKKVRISL 1030 RSAGIPLSLA EVEVYTYK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete genome sequence of a virulent isolate of Streptococcus pneumoniae." Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D., Peterson S., Heidelberg J., DeBoy R.T., Haft D.H., Dodson R.J., Durkin A.S., Gwinn M., Kolonay J.F., Nelson W.C., Peterson J.D., Umayam L.A., White O., Salzberg S.L. , Lewis M.R., Radune D., Holtzapple E., Khouri H., Wolf A.M., Utterback T.R., Hansen C.L., McDonald L.A., Feldblyum T.V., Angiuoli S., Dickinson T., Hickey E.K., Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A., Morrison D.A., Hollingshead S.K., Fraser C.M. Science 293:498-506(2001) [PubMed: 11463916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-334 / TIGR4.
[2]	"Blood group antigen recognition by a Streptococcus pneumoniae virulence factor." Boraston A.B., Wang D., Burke R.D. J. Biol. Chem. 281:35263-35271(2006) [PubMed: 16987809] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 601-745 IN COMPLEX WITH CALCIUM; FUCOSE AND N-ACETYL-D-GLUCOSAMINE.
[3]	"Differential recognition and hydrolysis of host carbohydrate antigens by Streptococcus pneumoniae family 98 glycoside hydrolases." Higgins M.A., Whitworth G.E., El Warry N., Randriantsoa M., Samain E., Burke R.D., Vocadlo D.J., Boraston A.B. J. Biol. Chem. 284:26161-26173(2009) [PubMed: 19608744] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 31-589 IN COMPLEX WITH FUCOSE; GALACTOSE AND N-ACETYL-D-GLUCOSAMINE.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE005672 Genomic DNA. Translation: AAK76213.1.

PIR

D95252.

RefSeq

NP_346573.1. NC_003028.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2J1R	X-ray	1.54	A/B	601-745	[»]
2J1S	X-ray	1.50	A/B	601-745	[»]
2J1T	X-ray	1.60	A/B	601-745	[»]
2J1U	X-ray	1.80	A/B	601-745	[»]
2J1V	X-ray	1.45	A/B	601-745	[»]
2J22	X-ray	1.80	A	897-1038	[»]
2WMF	X-ray	1.50	A	31-589	[»]
2WMG	X-ray	2.30	A	31-587	[»]
2WMH	X-ray	1.70	A	31-589	[»]

ProteinModelPortal

Q97N96.

SMR

Q97N96. Positions 604-744, 902-1038.

ModBase

Search...

Protein family/group databases

CAZy

CBM47. Carbohydrate-Binding Module Family 47.
GH98. Glycoside Hydrolase Family 98.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

EBSTRT00000027065; EBSTRP00000026157; EBSTRG00000027065.

GeneID

931935.

GenomeReviews

Gene locus SP_2159 in contig AE005672_GR.

KEGG

spn:SP_2159.

PATRIC

19708923. VBIStrPne105772_2253.

TIGR

SP_2159.

Phylogenomic databases

GeneTree

EBGT00050000029709.

HOGENOM

HBG702767.

OMA

VSFPTPD.

ProtClustDB

CLSK2301321.

Enzyme and pathway databases

BioCyc

SPNE170187-1:SP_2159-MONOMER.

Family and domain databases

InterPro

IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR013191. Glyco_hydro_98.
IPR013190. Glyco_hydro_98_C.
[Graphical view]

Pfam

PF00754. F5_F8_type_C. 3 hits.
PF08307. Glyco_hydro_98C. 1 hit.
PF08306. Glyco_hydro_98M. 1 hit.
[Graphical view]

SUPFAM

SSF49785. Gal_bind_like. 3 hits.

PROSITE

PS50022. FA58C_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q97N96_STRPN

Accession

Primary (citable) accession number: Q97N96

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2001
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)