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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi149 – 156ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:CA_C0001
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001141651 – 446Chromosomal replication initiator protein DnaAAdd BLAST446

Proteomic databases

PRIDEiQ97N35

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C0001

Structurei

3D structure databases

ProteinModelPortaliQ97N35
SMRiQ97N35
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
HOGENOMiHOG000235658
KOiK02313
OMAiREFNPLF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q97N35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQLNELWQ KTINIIKGEL TEVSFNTWIK SITPISIDKD SIRLSVPNQF
60 70 80 90 100
TKEILENRYK DLIINSMKII TTKKYDIAFL ISSEEALETD EDQETDTNNV
110 120 130 140 150
NTDTSSSMLN PKYKFDSFVI GNSNRFAHAA CLAVAEAPAK AYNPLFIYGG
160 170 180 190 200
VGLGKTHLMQ AIGHYILDNN PKAKVVYVSS EKFTNELINS IKDDKNVEFR
210 220 230 240 250
NKYRNVDVLL IDDVQFIAGK ERTQEEFFHT FNALHENNKQ IILSSDRPPK
260 270 280 290 300
EIPTLEDRLR SRFEWGLIAD IQAPDFETRI AILKKKADVE HLNIPNDVMV
310 320 330 340 350
YIATQIKSNI RELEGALIRI VAFSSLTNKE ISVDLASEAL KDIISSKQNK
360 370 380 390 400
QITIDLIQDV VSSYFNLRIE DFKSARRTKN IAFPRQIAMY LSRKLTDMSL
410 420 430 440
PKIGEAFGGR DHTTVIHAYE KISSALKEDD DLKYTINEIT KRFSPK
Length:446
Mass (Da):50,869
Last modified:October 1, 2001 - v1
Checksum:iBF181A5BDEFF4BDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK77988.1
PIRiA96900
RefSeqiNP_346648.1, NC_003030.1
WP_010963330.1, NC_003030.1

Genome annotation databases

EnsemblBacteriaiAAK77988; AAK77988; CA_C0001
GeneIDi1116184
KEGGicac:CA_C0001
PATRICifig|272562.8.peg.180

Similar proteinsi

Entry informationi

Entry nameiDNAA_CLOAB
AccessioniPrimary (citable) accession number: Q97N35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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