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Protein

dCTP deaminase, dUMP-forming

Gene

dcd

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.UniRule annotation

Catalytic activityi

dCTP + 2 H2O = dUMP + diphosphate + NH3.UniRule annotation

Pathwayi: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. dCTP deaminase, dUMP-forming (dcd)
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP, the pathway dUMP biosynthesis and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei108 – 109Important for bifunctional activityUniRule annotation2
Binding sitei111dCTPUniRule annotation1
Active sitei121Proton donor/acceptorUniRule annotation1
Binding sitei138dCTPUniRule annotation1
Binding sitei151dCTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi93 – 98dCTP bindingUniRule annotation6
Nucleotide bindingi119 – 121dCTP bindingUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00610; UER00667

Names & Taxonomyi

Protein namesi
Recommended name:
dCTP deaminase, dUMP-formingUniRule annotation (EC:3.5.4.30UniRule annotation)
Alternative name(s):
Bifunctional dCTP deaminase:dUTPaseUniRule annotation
DCD-DUTUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:CA_C0025
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001559791 – 173dCTP deaminase, dUMP-formingAdd BLAST173

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi272562.CA_C0025

Structurei

3D structure databases

ProteinModelPortaliQ97N13
SMRiQ97N13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107S9R Bacteria
COG0717 LUCA
HOGENOMiHOG000228601
KOiK01494
OMAiPNSYNVR

Family and domain databases

CDDicd07557 trimeric_dUTPase, 1 hit
Gene3Di2.70.40.10, 1 hit
HAMAPiMF_00146 dCTP_deaminase, 1 hit
InterProiView protein in InterPro
IPR010550 dCTP_deam_bac
IPR011962 dCTP_deaminase
IPR036157 dUTPase-like_sf
IPR033704 dUTPase_trimeric
PfamiView protein in Pfam
PF06559 DCD, 1 hit
SUPFAMiSSF51283 SSF51283, 1 hit
TIGRFAMsiTIGR02274 dCTP_deam, 1 hit

Sequencei

Sequence statusi: Complete.

Q97N13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILSGKQIKD SLGKDIVIEP FNEKQINPNS YNLKLHNELL VYDEEVLDMK
60 70 80 90 100
KPNKTKKLII PEEGIVLEPR KLYLGRTLEY TETDKYVPML EGRSSIGRLG
110 120 130 140 150
VFIHVTAGFG DVGFKGYWTL EIFCVEPIRI YSGVEICQIY YHDVGGDYEK
160 170
YSSGKYQNNK GIQPSLLYKD FIN
Length:173
Mass (Da):19,909
Last modified:October 1, 2001 - v1
Checksum:i97393788C854FD65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK78012.1
PIRiA96903
RefSeqiNP_346672.1, NC_003030.1
WP_010963354.1, NC_003030.1

Genome annotation databases

EnsemblBacteriaiAAK78012; AAK78012; CA_C0025
GeneIDi1116208
KEGGicac:CA_C0025
PATRICifig|272562.8.peg.204

Similar proteinsi

Entry informationi

Entry nameiDCDB_CLOAB
AccessioniPrimary (citable) accession number: Q97N13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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