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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processPorphyrin biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:CA_C0099
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001204011 – 422Glutamate-1-semialdehyde 2,1-aminomutaseAdd BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei264N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ97MU2

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272562.CA_C0099

Structurei

3D structure databases

ProteinModelPortaliQ97MU2
SMRiQ97MU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CDM Bacteria
COG0001 LUCA
HOGENOMiHOG000020210
KOiK01845
OMAiWGPLIFG

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q97MU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKEIFEES KEYMPGGVNS PVRAYMDLNI DPPIIKSGKD SHLFDEEGKE
60 70 80 90 100
YIDFIEAWGP MILGHKNQKV LNEVKEVLDE GVGFGAPTSL ELKLAKYICT
110 120 130 140 150
TVDNVEMIRM VNSGTEATMS AVKLARGYTK RDKIIKFAGC YHGHFDGFLV
160 170 180 190 200
EAGSGVLTQN IPGSPGVPKG SIENTLIAEY NNVESVEVLF NKYKDEIAAV
210 220 230 240 250
IIEPVAGNMG VIPAKKEFLV KLRELCTENQ SILIFDEVMS GFRVAYKGAQ
260 270 280 290 300
SLYGVTPDLI TFAKIMGGGF PCGAYGGKKE IMKQLSPLGP VYQAGTMSGN
310 320 330 340 350
PVVMAAGYAS LRQLHENPEY YTYMDKLGSK LEAGILEISK EKGIPLVVNR
360 370 380 390 400
CVNMMTIFFN KAKEVKSYSD AKASDTKMFA RFAEHMITSG IYVPPSQFEA
410 420
MFLGVKHTEE DIERFLDVMK KL
Length:422
Mass (Da):46,615
Last modified:October 1, 2001 - v1
Checksum:iE37F273660CDDA2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA Translation: AAK78084.1
PIRiA96912
RefSeqiNP_346744.1, NC_003030.1
WP_010963426.1, NC_003030.1

Genome annotation databases

EnsemblBacteriaiAAK78084; AAK78084; CA_C0099
GeneIDi1116282
KEGGicac:CA_C0099
PATRICifig|272562.8.peg.282

Similar proteinsi

Entry informationi

Entry nameiGSA_CLOAB
AccessioniPrimary (citable) accession number: Q97MU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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