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Q97MN6

- GLMS_CLOAB

UniProt

Q97MN6 - GLMS_CLOAB

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei603 – 6031For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciCACE272562:GJIH-180-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:CA_C0158
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 608607Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135322Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272562.CA_C0158.

Structurei

3D structure databases

ProteinModelPortaliQ97MN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 217216Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini285 – 424140SIS 1UniRule annotationAdd
BLAST
Domaini453 – 598146SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
HOGENOMiHOG000258896.
KOiK00820.
OMAiSVFETQT.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q97MN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIVGYSGK KEASSILVEG LSKLEYRGYD SAGVAILNDG KINVSKCKGR
60 70 80 90 100
LVNLENKLEE NPIAGNIGIG HTRWATHGEP SDLNAHPHSN KDNTISVVHN
110 120 130 140 150
GIIENYMQLR TWLKSKGYEF KSETDTEVIP NLVDYFYEGN LLDAVIKAIS
160 170 180 190 200
KVEGSYALGI VSSKEPDKVV AVRKDSPLIV GISEDGNFIA SDVPAILNHT
210 220 230 240 250
RDIYYIKDKE FVVLTSEGVE FYSNEGEKIE KELNHIEWDA NAAEKGGYEH
260 270 280 290 300
FMLKEIYEQP KAIRDTMTSR IIAGQPIKLD DISITKEQIE NIDKIYIVAC
310 320 330 340 350
GTAYHAGVVG KYVIEKFARI PVEVDIASEF RYRDPIITKN TLMIVLSQSG
360 370 380 390 400
ETADTLAALR EAKSIGARVI AVTNVVGSSV ARAADDILYT WAGPEIAVAS
410 420 430 440 450
TKAYTTQLIT MYILGLFFAQ NKNTLTNEEI EKIKADMLTL PEKAEEVLAS
460 470 480 490 500
KEKVQKFAAN TYMHKDMFYL GRGIDYAVAM EGALKLKEIS YIHAEAYAGG
510 520 530 540 550
ELKHGTIALI EEGTVVVALG TQSDIYDKMV SNIKEVTTRG AKVLGIAAEG
560 570 580 590 600
RKGMEEVVDS VIYVPEVNDM LLPVLSVMQL QLLAYYVSVE KGCDVDKPRN

LAKSVTVE
Length:608
Mass (Da):66,949
Last modified:January 23, 2007 - v3
Checksum:i715F3DB9D18B3B35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK78142.1.
PIRiC96919.
RefSeqiNP_346802.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK78142; AAK78142; CA_C0158.
GeneIDi1116341.
KEGGicac:CA_C0158.
PATRICi32034609. VBICloAce74127_0342.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK78142.1 .
PIRi C96919.
RefSeqi NP_346802.1. NC_003030.1.

3D structure databases

ProteinModelPortali Q97MN6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272562.CA_C0158.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK78142 ; AAK78142 ; CA_C0158 .
GeneIDi 1116341.
KEGGi cac:CA_C0158.
PATRICi 32034609. VBICloAce74127_0342.

Phylogenomic databases

eggNOGi COG0449.
HOGENOMi HOG000258896.
KOi K00820.
OMAi SVFETQT.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci CACE272562:GJIH-180-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiGLMS_CLOAB
AccessioniPrimary (citable) accession number: Q97MN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3