Reviewed, UniProtKB/Swiss-Prot Q97LQ3 (UPPP1_CLOAB)

Names and origin

Protein names

Recommended name:
    Undecaprenyl-diphosphatase 1
    EC=3.6.1.27
Alternative name(s):
    Undecaprenyl pyrophosphate phosphatase 1
    Bacitracin resistance protein 1

Gene names

Name:	uppP1
Synonyms:	bacA1, upk1
Ordered Locus Names:	CA_C0501

Organism

Clostridium acetobutylicum [Complete proteome] [HAMAP]

Taxonomic identifier

1488 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	274 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the uppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 274	274	Undecaprenyl-diphosphatase 1 HAMAP MF_01006		PRO_0000151134
Regions
	Transmembrane	47 – 67	21	Potential
	Transmembrane	85 – 105	21	Potential
	Transmembrane	113 – 133	21	Potential
	Transmembrane	150 – 170	21	Potential
	Transmembrane	196 – 216	21	Potential
	Transmembrane	225 – 245	21	Potential
	Transmembrane	253 – 273	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q97LQ3-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 4282F96E396E7028	FASTA	274	30,605
	10 20 30 40 50 60 MEHIEILKAI FLGIVEGITE WLPISSTGHM ILVNEFIRLN VTEAFKQVFL VVIQLGAILS 70 80 90 100 110 120 VVLLYFNKLI PFSLNGGFYL KKDVVSMWIK IIISCIPATI VGIPFDDKID ALFYNYQTVS 130 140 150 160 170 180 ITLISFGILF IMIENHNKGK HPRITSISEI TYTTAVLIGI FQLIAAVFPG TSRSGATIVG 190 200 210 220 230 240 ALLIGVSRTV AAEYTFFLAI PVMFGASLLK LFKFGLHFTS TEITILFIGM LSAFIVSILA 250 260 270 IKFLMIYIKR HDFKAFGWYR IILGCAVLVY FLIV

References

[1]

"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001437 Genomic DNA. Translation: AAK78481.1.
PIR	F96961.
RefSeq	NP_347141.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1116684.
GenomeReviews	Gene locus CA_C0501 in contig AE001437_GR.
KEGG	cac:CAC0501.
NMPDR	fig|272562.1.peg.670.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q97LQ3.
OMA	IYGIAFI.
Enzyme and pathway databases
BioCyc	CACE272562:CAC0501-MON.
BRENDA	3.6.1.27. 2866.
Family and domain databases
HAMAP	MF_01006. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
Pfam	PF02673. BacA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UPPP1_CLOAB

Accession

Primary (citable) accession number: Q97LQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	October 1, 2001
Last modified:	November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)