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Q97LQ3

- UPPP1_CLOAB

UniProt

Q97LQ3 - UPPP1_CLOAB

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Protein
Undecaprenyl-diphosphatase 1
Gene
uppP1, bacA1, upk1, CA_C0501
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCACE272562:GJIH-542-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase 1 (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein 1
Undecaprenyl pyrophosphate phosphatase 1
Gene namesi
Name:uppP1
Synonyms:bacA1, upk1
Ordered Locus Names:CA_C0501
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei47 – 6721Helical; Reviewed prediction
Add
BLAST
Transmembranei85 – 10521Helical; Reviewed prediction
Add
BLAST
Transmembranei113 – 13321Helical; Reviewed prediction
Add
BLAST
Transmembranei150 – 17021Helical; Reviewed prediction
Add
BLAST
Transmembranei196 – 21621Helical; Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Transmembranei253 – 27321Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Undecaprenyl-diphosphatase 1UniRule annotation
PRO_0000151134Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C0501.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiMILVEEF.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97LQ3-1 [UniParc]FASTAAdd to Basket

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MEHIEILKAI FLGIVEGITE WLPISSTGHM ILVNEFIRLN VTEAFKQVFL    50
VVIQLGAILS VVLLYFNKLI PFSLNGGFYL KKDVVSMWIK IIISCIPATI 100
VGIPFDDKID ALFYNYQTVS ITLISFGILF IMIENHNKGK HPRITSISEI 150
TYTTAVLIGI FQLIAAVFPG TSRSGATIVG ALLIGVSRTV AAEYTFFLAI 200
PVMFGASLLK LFKFGLHFTS TEITILFIGM LSAFIVSILA IKFLMIYIKR 250
HDFKAFGWYR IILGCAVLVY FLIV 274
Length:274
Mass (Da):30,605
Last modified:October 1, 2001 - v1
Checksum:i4282F96E396E7028
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001437 Genomic DNA. Translation: AAK78481.1.
PIRiF96961.
RefSeqiNP_347141.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK78481; AAK78481; CA_C0501.
GeneIDi1116684.
KEGGicac:CA_C0501.
PATRICi32035357. VBICloAce74127_0700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001437 Genomic DNA. Translation: AAK78481.1 .
PIRi F96961.
RefSeqi NP_347141.1. NC_003030.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 272562.CA_C0501.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK78481 ; AAK78481 ; CA_C0501 .
GeneIDi 1116684.
KEGGi cac:CA_C0501.
PATRICi 32035357. VBICloAce74127_0700.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi MILVEEF.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CACE272562:GJIH-542-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiUPPP1_CLOAB
AccessioniPrimary (citable) accession number: Q97LQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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