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Q97LB6

- SYL_CLOAB

UniProt

Q97LB6 - SYL_CLOAB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei575 – 5751ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCACE272562:GJIH-687-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:CA_C0646
    OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
    Taxonomic identifieri272562 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000814: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 812812Leucine--tRNA ligasePRO_0000152002Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272562.CA_C0646.

    Structurei

    3D structure databases

    ProteinModelPortaliQ97LB6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi572 – 5765"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiHELEVYT.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q97LB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTYSTKVDE KWQKKWEETS LYKFDENNLE KKLYVLEMFS YPSGAKLHAG    50
    HWFNYAPVDS WARFKKMTGY NVFQPMGFDA FGLPAENYAI KTGIHPKDST 100
    LKNIETMEKQ LKSMGAMFNW DHEVITCTPD YYKWTQWLFL ELYKNGLAYR 150
    KKAPANWCPS CNTVLANEQV VDGSCERCGT EVIKKDLTQW FFKITNYAEE 200
    LLQKLDELDW PEKTKAMQKH WIGKSKGAEV TFKVDNSDLK FDVFTTRVDT 250
    LCGVTYVVLA PESPLADELT KPEYKEKVEE YKLQAQKQSE IERQSLTREK 300
    TGVFTGSYAI NPINNKKVPI WIADYVIYTY GTGAVMAVPS HDERDFAFAT 350
    KYDLPIVRVV EGGEELPFTG YGPLVNSGEF DGLKGNKAKE AIVSKLSEND 400
    LGRWKVNYRL RDWLVSRQRY WGAPIPVVYC EKCGIVPVPE KDLPVELPYN 450
    VEFNPTGKSP LTTSEEFMNT TCPHCGGHAT RESDTLDTFV CSSWYYLRYA 500
    DNENSDAPFD KEKISKMLPV DKYVGGPEHA CMHLLYARFI TKALRDIGYL 550
    NFDEPFLSLR HQGLILGPDG QKMSKSKGNT ISPDDIIAEH GSDVFRMYLM 600
    FGFDYAEGGA WSDDGVKAMS KFVDRFSRMI ETAKEEINNP KNSKTDMGKE 650
    EKELNYVRNH SIKAVTEDMD KFQFNTCIAR LMEFTNSLSK YLTVDNKNIK 700
    LLKDTTIDII KLIAPFAPHF AEEQWNIIEE KYSVFNEKWP EFDEKALVKD 750
    EVEIAIQING KIKAKINIAT NLSEDEIKSA ALADDKVKAA TDGKNIVKVI 800
    VIKGRLVNIV VK 812
    Length:812
    Mass (Da):92,889
    Last modified:October 1, 2001 - v1
    Checksum:i8556803C1FCFE29C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001437 Genomic DNA. Translation: AAK78623.1.
    PIRiD96979.
    RefSeqiNP_347283.1. NC_003030.1.

    Genome annotation databases

    EnsemblBacteriaiAAK78623; AAK78623; CA_C0646.
    GeneIDi1116829.
    KEGGicac:CA_C0646.
    PATRICi32035655. VBICloAce74127_0849.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001437 Genomic DNA. Translation: AAK78623.1 .
    PIRi D96979.
    RefSeqi NP_347283.1. NC_003030.1.

    3D structure databases

    ProteinModelPortali Q97LB6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272562.CA_C0646.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK78623 ; AAK78623 ; CA_C0646 .
    GeneIDi 1116829.
    KEGGi cac:CA_C0646.
    PATRICi 32035655. VBICloAce74127_0849.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi HELEVYT.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci CACE272562:GJIH-687-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 2 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

    Entry informationi

    Entry nameiSYL_CLOAB
    AccessioniPrimary (citable) accession number: Q97LB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3