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Q97LB6

- SYL_CLOAB

UniProt

Q97LB6 - SYL_CLOAB

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei575 – 5751ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCACE272562:GJIH-687-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CA_C0646
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 812812Leucine--tRNA ligasePRO_0000152002Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C0646.

Structurei

3D structure databases

ProteinModelPortaliQ97LB6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi572 – 5765"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHELEVYT.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97LB6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTYSTKVDE KWQKKWEETS LYKFDENNLE KKLYVLEMFS YPSGAKLHAG
60 70 80 90 100
HWFNYAPVDS WARFKKMTGY NVFQPMGFDA FGLPAENYAI KTGIHPKDST
110 120 130 140 150
LKNIETMEKQ LKSMGAMFNW DHEVITCTPD YYKWTQWLFL ELYKNGLAYR
160 170 180 190 200
KKAPANWCPS CNTVLANEQV VDGSCERCGT EVIKKDLTQW FFKITNYAEE
210 220 230 240 250
LLQKLDELDW PEKTKAMQKH WIGKSKGAEV TFKVDNSDLK FDVFTTRVDT
260 270 280 290 300
LCGVTYVVLA PESPLADELT KPEYKEKVEE YKLQAQKQSE IERQSLTREK
310 320 330 340 350
TGVFTGSYAI NPINNKKVPI WIADYVIYTY GTGAVMAVPS HDERDFAFAT
360 370 380 390 400
KYDLPIVRVV EGGEELPFTG YGPLVNSGEF DGLKGNKAKE AIVSKLSEND
410 420 430 440 450
LGRWKVNYRL RDWLVSRQRY WGAPIPVVYC EKCGIVPVPE KDLPVELPYN
460 470 480 490 500
VEFNPTGKSP LTTSEEFMNT TCPHCGGHAT RESDTLDTFV CSSWYYLRYA
510 520 530 540 550
DNENSDAPFD KEKISKMLPV DKYVGGPEHA CMHLLYARFI TKALRDIGYL
560 570 580 590 600
NFDEPFLSLR HQGLILGPDG QKMSKSKGNT ISPDDIIAEH GSDVFRMYLM
610 620 630 640 650
FGFDYAEGGA WSDDGVKAMS KFVDRFSRMI ETAKEEINNP KNSKTDMGKE
660 670 680 690 700
EKELNYVRNH SIKAVTEDMD KFQFNTCIAR LMEFTNSLSK YLTVDNKNIK
710 720 730 740 750
LLKDTTIDII KLIAPFAPHF AEEQWNIIEE KYSVFNEKWP EFDEKALVKD
760 770 780 790 800
EVEIAIQING KIKAKINIAT NLSEDEIKSA ALADDKVKAA TDGKNIVKVI
810
VIKGRLVNIV VK
Length:812
Mass (Da):92,889
Last modified:October 1, 2001 - v1
Checksum:i8556803C1FCFE29C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK78623.1.
PIRiD96979.
RefSeqiNP_347283.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK78623; AAK78623; CA_C0646.
GeneIDi1116829.
KEGGicac:CA_C0646.
PATRICi32035655. VBICloAce74127_0849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK78623.1 .
PIRi D96979.
RefSeqi NP_347283.1. NC_003030.1.

3D structure databases

ProteinModelPortali Q97LB6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272562.CA_C0646.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK78623 ; AAK78623 ; CA_C0646 .
GeneIDi 1116829.
KEGGi cac:CA_C0646.
PATRICi 32035655. VBICloAce74127_0849.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HELEVYT.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci CACE272562:GJIH-687-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiSYL_CLOAB
AccessioniPrimary (citable) accession number: Q97LB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2001
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3