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Q97L67 (UXAB_CLOAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Altronate oxidoreductase

EC=1.1.1.58
Alternative name(s):
Tagaturonate dehydrogenase
Tagaturonate reductase
Gene names
Name:uxaB
Ordered Locus Names:CA_C0695
OrganismClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) [Reference proteome] [HAMAP]
Taxonomic identifier272562 [NCBI]
Taxonomic lineageBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Protein attributes

Sequence length482 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP-Rule MF_00670

Pathway

Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP-Rule MF_00670

Sequence similarities

Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

tagaturonate reductase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 482482Altronate oxidoreductase HAMAP-Rule MF_00670
PRO_0000170741

Regions

Nucleotide binding18 – 2912NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97L67 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: A569F3B18D0919CA

FASTA48255,250
        10         20         30         40         50         60 
MKLNRSNFSE FKKYPEKILQ FGEGNFLRAF VDWQVDRMNK AADFNAGVVI VQPLEQGLVD 

        70         80         90        100        110        120 
MLNEQDGLYT LYLQGLKEGK AVKEHSVIDC VTRGLNPYTQ YEEYLKLAEN PEMEIVISNT 

       130        140        150        160        170        180 
TEAGIAFDEN DKLGRTCQNS YPGKLTAFLY RRFKTFNGDK SKGMLIIPCE LIDRNGEKLK 

       190        200        210        220        230        240 
ATILKFAELW NLEKEFADWI EEANTFCCTL VDRIVPGYPR DTIEEVHAEL GYEDSLVDVG 

       250        260        270        280        290        300 
EQFHLWVIEG PEWIKDILPF EKAGVNIQVV KDVTPYRTRK VRILNGAHTA LVPVAYLYGL 

       310        320        330        340        350        360 
DTVGHSVEDK VIGKYLTELV YDEIIPTLDL PEEELKYFAG AVLERFLNPF VNHYLMSIAL 

       370        380        390        400        410        420 
NSMPKFETRD LPSLLEYKKR KGQLPKKLVF SLAALIEFYK GKRGDEDIKL ADGEDILELY 

       430        440        450        460        470        480 
KDLWSKFDGT DACYRNIVET VLGYEKNWKM NLNELEGLTD AVTENLIKID KLGMKEAVKS 


VM 

« Hide

References

[1]"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum."
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.
J. Bacteriol. 183:4823-4838(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001437 Genomic DNA. Translation: AAK78672.1.
PIRE96985.
RefSeqNP_347332.1. NC_003030.1.

3D structure databases

ProteinModelPortalQ97L67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272562.CA_C0695.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK78672; AAK78672; CA_C0695.
GeneID1116878.
KEGGcac:CA_C0695.
PATRIC32035757. VBICloAce74127_0898.

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000029586.
KOK00041.
OMASKFKVRV.
OrthoDBEOG6CVVB8.

Enzyme and pathway databases

BioCycCACE272562:GJIH-738-MONOMER.
UniPathwayUPA00246.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
HAMAPMF_00670. Altron_oxidoreduct.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR023668. Altronate_OxRdtase.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUXAB_CLOAB
AccessionPrimary (citable) accession number: Q97L67
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways