Reviewed, UniProtKB/Swiss-Prot Q97L67 (UXAB_CLOAB)

Names and origin

Protein names

Recommended name:
    Altronate oxidoreductase
    EC=1.1.1.58
Alternative name(s):
    Tagaturonate reductase
    Tagaturonate dehydrogenase

Gene names

Name:	uxaB
Ordered Locus Names:	CA_C0695

Organism

Clostridium acetobutylicum [Complete proteome] [HAMAP]

Taxonomic identifier

1488 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	482 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-altronate + NAD+ = D-tagaturonate + NADH. HAMAP MF_00670
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00670
Sequence similarities	Belongs to the mannitol dehydrogenase family. UxaB subfamily.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro tagaturonate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 482	482	Altronate oxidoreductase HAMAP MF_00670		PRO_0000170741
Regions
	Nucleotide binding	18 – 29	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q97L67-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: A569F3B18D0919CA	FASTA	482	55,250
	10 20 30 40 50 60 MKLNRSNFSE FKKYPEKILQ FGEGNFLRAF VDWQVDRMNK AADFNAGVVI VQPLEQGLVD 70 80 90 100 110 120 MLNEQDGLYT LYLQGLKEGK AVKEHSVIDC VTRGLNPYTQ YEEYLKLAEN PEMEIVISNT 130 140 150 160 170 180 TEAGIAFDEN DKLGRTCQNS YPGKLTAFLY RRFKTFNGDK SKGMLIIPCE LIDRNGEKLK 190 200 210 220 230 240 ATILKFAELW NLEKEFADWI EEANTFCCTL VDRIVPGYPR DTIEEVHAEL GYEDSLVDVG 250 260 270 280 290 300 EQFHLWVIEG PEWIKDILPF EKAGVNIQVV KDVTPYRTRK VRILNGAHTA LVPVAYLYGL 310 320 330 340 350 360 DTVGHSVEDK VIGKYLTELV YDEIIPTLDL PEEELKYFAG AVLERFLNPF VNHYLMSIAL 370 380 390 400 410 420 NSMPKFETRD LPSLLEYKKR KGQLPKKLVF SLAALIEFYK GKRGDEDIKL ADGEDILELY 430 440 450 460 470 480 KDLWSKFDGT DACYRNIVET VLGYEKNWKM NLNELEGLTD AVTENLIKID KLGMKEAVKS VM

References

[1]

"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001437 Genomic DNA. Translation: AAK78672.1.
PIR	E96985.
RefSeq	NP_347332.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1116878.
GenomeReviews	Gene locus CA_C0695 in contig AE001437_GR.
KEGG	cac:CAC0695.
NMPDR	fig|272562.1.peg.861.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q97L67.
OMA	Q97L67. SIFPCEL.
Enzyme and pathway databases
BioCyc	CACE272562:CAC0695-MON.
BRENDA	1.1.1.58. 2866.
Family and domain databases
HAMAP	MF_00670. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
ProtoNet	Search...

Entry information

Entry name

UXAB_CLOAB

Accession

Primary (citable) accession number: Q97L67

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)