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Q97KW7 (PSD2_CLOAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphatidylserine decarboxylase proenzyme 2
EC=4.1.1.65

Cleaved into the following 2 chains:

  1. Phosphatidylserine decarboxylase alpha chain 2
  2. Phosphatidylserine decarboxylase beta chain 2
Gene names
Name:psd2
Ordered Locus Names:CA_C0799
OrganismClostridium acetobutylicum
Taxonomic identifier1488 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length291 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00663

Cofactor

Pyruvoyl group By similarity. HAMAP MF_00663

Pathway

Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00663

Sequence similarities

Belongs to the phosphatidylserine decarboxylase family. Type 2 subfamily.

Ontologies

Keywords
   Biological processPhospholipid biosynthesis
   LigandPyruvate
   Molecular functionDecarboxylase
Lyase
   PTMZymogen
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processphospholipid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphatidylserine decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 250250Phosphatidylserine decarboxylase beta chain 2 By similarity
PRO_0000029737
Chain251 – 29141Phosphatidylserine decarboxylase alpha chain 2 By similarity
PRO_0000029738

Sites

Site250 – 2512Cleavage (non-hydrolytic) By similarity

Amino acid modifications

Modified residue2511Pyruvic acid (Ser) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97KW7 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 6CC2F1BBCC87489D

FASTA29134,070
        10         20         30         40         50         60 
MSITIFNRDL KEIYYEKQYK NGQLKFLYNT ILGRMLLKLF ISTRLFSKIN AIFNNNKGSI 

        70         80         90        100        110        120 
KKIEPFINEY KIDMSEYEKK EYTSFDDFFT RKILEGKRSF SKEKSHLISP ADSKLMVYEI 

       130        140        150        160        170        180 
DDDLKMNIKN SIYTVGELLN DEKLSREYKN GTCLIFRLTV DDYHRYCFID DGSLKYRKVI 

       190        200        210        220        230        240 
NGRLHTVGPI SSKRYKVYSE NNREYSVLKT RNFGKVIQIE VGALLVGKIK NHSIKVFKKG 

       250        260        270        280        290 
DEKGYFCFGG STIVLLFKEK VIKMDEDILE YSKAGIETKI KMGEKIGETN D

« Hide

References

[1]"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum."
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.
J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001437 Genomic DNA. Translation: AAK78775.1.
PIRD96998.
RefSeqNP_347435.1. NC_003030.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1116982.
GenomeReviewsGene locus CA_C0799 in contig AE001437_GR.
KEGGcac:CA_C0799.
NMPDRfig|272562.1.peg.964.
PATRIC32035969. VBICloAce74127_1004.

Phylogenomic databases

HOGENOMHBG302256.
OMAEVKYPLE.
PhylomeDBQ97KW7.

Enzyme and pathway databases

BioCycCACE272562:CAC0799-MONOMER.

Family and domain databases

HAMAPMF_00663. PS_decarb_type2.
[Tree]
InterProIPR003817. PS_Dcarbxylase.
IPR005221. PS_decarb.
[Graphical view]
KOK01613.
PANTHERPTHR10067. PS_decarb. 1 hit.
PfamPF02666. PS_Dcarbxylase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePSD2_CLOAB
AccessionPrimary (citable) accession number: Q97KW7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2001
Last modified: January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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