Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q97KI2

- HISX_CLOAB

UniProt

Q97KI2 - HISX_CLOAB

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei131 – 1311NADUniRule annotation
    Binding sitei193 – 1931NADUniRule annotation
    Binding sitei216 – 2161NADUniRule annotation
    Binding sitei239 – 2391SubstrateUniRule annotation
    Metal bindingi261 – 2611ZincUniRule annotation
    Binding sitei261 – 2611SubstrateUniRule annotation
    Metal bindingi264 – 2641ZincUniRule annotation
    Binding sitei264 – 2641SubstrateUniRule annotation
    Active sitei329 – 3291Proton acceptorUniRule annotation
    Active sitei330 – 3301Proton acceptorUniRule annotation
    Binding sitei330 – 3301SubstrateUniRule annotation
    Metal bindingi363 – 3631ZincUniRule annotation
    Binding sitei363 – 3631SubstrateUniRule annotation
    Binding sitei417 – 4171SubstrateUniRule annotation
    Metal bindingi422 – 4221ZincUniRule annotation
    Binding sitei422 – 4221SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciCACE272562:GJIH-980-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:CA_C0937
    OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
    Taxonomic identifieri272562 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000814: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 431431Histidinol dehydrogenasePRO_0000135756Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272562.CA_C0937.

    Structurei

    3D structure databases

    ProteinModelPortaliQ97KI2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    HOGENOMiHOG000243914.
    KOiK00013.
    OMAiGFLFHAN.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q97KI2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDIIRIIQD GSLDGEKYFQ SLKERQGKEN AEIIKTVKFI IDNVKENGDK    50
    ALIEYTSKFD KVELQSIEVT KEEIKAAYSK VENDFICALK TAKENIEEYH 100
    SKQVQNSYVI TKENGIVMGR TVRGLDKVGI YVPGGTAAYP SSVIMNAVPA 150
    KVAGVNKIIM TTPPMKDGFV NPSILVAADL AGVDKIYKVG GAQAIAALAF 200
    GTETIDKVDK IVGPGNIFVA MAKKSVYGFV DIDMIAGPSE ILVISDETGN 250
    PKFIAADLMS QAEHDTLASS ILVTTSKELI GKVIEEIKLQ VEGLSRKEII 300
    LEALRNFGAI ILVDSISRAI EIGNVVAPEH LEIITPNPFE YLNDIKNAGS 350
    IFLGSYSPEP LGDYMAGPNH VLPTSGTARF SSPLSVDDFV KKSSYLYYSE 400
    KALRNVNDKV VKIAETEGLT AHANSIKVRF K 431
    Length:431
    Mass (Da):46,930
    Last modified:October 1, 2001 - v1
    Checksum:i70AFA3CB1946DF19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001437 Genomic DNA. Translation: AAK78913.1.
    PIRiF97015.
    RefSeqiNP_347573.1. NC_003030.1.

    Genome annotation databases

    EnsemblBacteriaiAAK78913; AAK78913; CA_C0937.
    GeneIDi1117120.
    KEGGicac:CA_C0937.
    PATRICi32036255. VBICloAce74127_1147.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001437 Genomic DNA. Translation: AAK78913.1 .
    PIRi F97015.
    RefSeqi NP_347573.1. NC_003030.1.

    3D structure databases

    ProteinModelPortali Q97KI2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272562.CA_C0937.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK78913 ; AAK78913 ; CA_C0937 .
    GeneIDi 1117120.
    KEGGi cac:CA_C0937.
    PATRICi 32036255. VBICloAce74127_1147.

    Phylogenomic databases

    eggNOGi COG0141.
    HOGENOMi HOG000243914.
    KOi K00013.
    OMAi GFLFHAN.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci CACE272562:GJIH-980-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

    Entry informationi

    Entry nameiHISX_CLOAB
    AccessioniPrimary (citable) accession number: Q97KI2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3