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Q97KF6 (UPPP2_CLOAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase 2
EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein 2
Undecaprenyl pyrophosphate phosphatase 2
Gene names
Name:uppP2
Synonyms:bacA2, upk2
Ordered Locus Names:CA_C0963
OrganismClostridium acetobutylicum
Taxonomic identifier1488 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006

Catalytic activity

Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Undecaprenyl-diphosphatase 2 HAMAP MF_01006
PRO_0000151135

Regions

Transmembrane19 – 4123Helical; Potential
Transmembrane56 – 7621Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane144 – 16421Helical; Potential
Transmembrane208 – 22821Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane251 – 27121Helical; Potential
Transmembrane285 – 30521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q97KF6 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 32FF21C78024F34D

FASTA30733,640
        10         20         30         40         50         60 
MYTNLIFIFK IILEGIIEGV TEFLPVSSTG HMIILGSIIG FKEGAKPVSL YGAEYIHMFE 

        70         80         90        100        110        120 
IIIQLGAILA IVVLYWDKIF SALKPSNLFP SMKEHEKSGI GVVGEFFVKG YNTMPGFKFW 

       130        140        150        160        170        180 
TNIVVACIPA IVIGLPFQKK IDKLLFFPAP VAAALMVGAV WMIFAENKYR KRAKIKSVDE 

       190        200        210        220        230        240 
ITIKQAIVIG CFQCLALWPG MSRSASTIIG AWIVGVATVA GAEFSFFLAI PMMLGASLLF 

       250        260        270        280        290        300 
LIKNSVVLSS VQILGLAVGF IVAFIVALVV VDRFISFLKK KPMRIFAVYR LAIGIIVLVL 


GFTKVIS

« Hide

References

[1]"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum."
Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R.
J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001437 Genomic DNA. Translation: AAK78939.1.
PIRH97018.
RefSeqNP_347599.1. NC_003030.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1117146.
GenomeReviewsGene locus CA_C0963 in contig AE001437_GR.
KEGGcac:CA_C0963.
NMPDRfig|272562.1.peg.1128.
PATRIC32036305. VBICloAce74127_1172.

Phylogenomic databases

HOGENOMHBG391969.
OMAWDKIMST.
PhylomeDBQ97KF6.
ProtClustDBPRK12554.

Enzyme and pathway databases

BioCycCACE272562:CAC0963-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
[Tree]
InterProIPR003824. Bacitracin-R_BacA.
[Graphical view]
KOK06153.
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. Undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP2_CLOAB
AccessionPrimary (citable) accession number: Q97KF6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: October 1, 2001
Last modified: January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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