Q97JF4 (UXUA_CLOAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	CA_C1332

Organism

Clostridium acetobutylicum

Taxonomic identifier

1488 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Mannonate dehydratase HAMAP MF_00106		PRO_0000170668

Sequences

	Sequence		Length	Mass (Da)
	Q97JF4 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: B8FFBFEFDDF2F383	FASTA	351	40,460
	10 20 30 40 50 60 MNLSFRWYGA DDAVKLQYIR QIPSIKSIVT AIYDVPVGEK WSIEAILKLK NEVESYGLNF 70 80 90 100 110 120 DVIESVPVHE DIKLGLKTRD KYIENYKENI RNLSKAGVKV ICYNFMPIFD WTRTQVDKVL 130 140 150 160 170 180 DDGSTTLVYY KNQLKKMDPL TGELSLPGWD SSYTKDQLSS LFEKYQNVDQ EVLWSNLEYF 190 200 210 220 230 240 LKQIIPVAEE CDVKMAIHPD DPPYNIFGLP RIITNEQNLD RFLKIVDSKY NGLTFCTGSL 250 260 270 280 290 300 GCASFNDVVK MVDKYSSQGR IHFMHVRNVK LLFDGSFEES AHYSPCGSLD IVEIMKVLHK 310 320 330 340 350 NKFDGYIRPD HGRMIWGETG RPGYGLYDRA LGAMYITGIW ETLEKISKED K

References

[1]

"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001437 Genomic DNA. Translation: AAK79300.1.
PIR	A97064.
RefSeq	NP_347960.1. NC_003030.1.
3D structure databases
ProteinModelPortal	Q97JF4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1117515.
GenomeReviews	Gene locus CA_C1332 in contig AE001437_GR.
KEGG	cac:CA_C1332.
NMPDR	fig|272562.1.peg.1489.
PATRIC	32037047. VBICloAce74127_1537.
Phylogenomic databases
HOGENOM	HBG585927.
OMA	IWETLEK.
PhylomeDB	Q97JF4.
ProtClustDB	PRK03906.
Enzyme and pathway databases
BioCyc	CACE272562:CAC1332-MONOMER.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_CLOAB

Accession

Primary (citable) accession number: Q97JF4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 6, 2002
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program