Q97JE0 (ARAA2_CLOAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-arabinose isomerase 2
EC=5.3.1.4

Gene names

Name:	araA2
Ordered Locus Names:	CA_C1346

Organism

Clostridium acetobutylicum

Taxonomic identifier

1488 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of L-arabinose to L-ribulose By similarity. HAMAP MF_00519
Catalytic activity	L-arabinose = L-ribulose. HAMAP MF_00519
Cofactor	Binds 1 manganese ion per subunit By similarity. HAMAP MF_00519
Pathway	Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 1/3. HAMAP MF_00519
Sequence similarities	Belongs to the arabinose isomerase family.

Ontologies

Keywords
Biological process	Arabinose catabolism Carbohydrate metabolism
Ligand	Manganese Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arabinose catabolic process Inferred from electronic annotation. Source: UniProtKB-KW fucose metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	L-arabinose isomerase activity Inferred from electronic annotation. Source: EC L-fucose isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 488	488	L-arabinose isomerase 2 HAMAP MF_00519		PRO_0000198384
Sites
	Metal binding	306	1	Manganese By similarity
	Metal binding	331	1	Manganese By similarity
	Metal binding	348	1	Manganese By similarity
	Metal binding	447	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q97JE0 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 2453F45FE4849FF3	FASTA	488	55,487
	10 20 30 40 50 60 MLENKKMEFW FVVGSQHLYG EEALKEVRKN SETIVDELNK SANLPYKIIF KDLATSADKI 70 80 90 100 110 120 KEIMKEVNYR DEVAGVITWM HTFSPAKMWI AGTKILQKPL LHFATQYNEN IPWKTIDMDY 130 140 150 160 170 180 MNLHQSAHGD REYGFINARL KKHNKVVVGY WKDKEVQKQV SDWMKVAAGY IASESIKVAR 190 200 210 220 230 240 FGDNMRNVAV TEGDKVEAQI QFGWTVDYFG IGDLVAEMDK VSQDEINKTY EEFKDLYILD 250 260 270 280 290 300 PGENDPAFYE KQVKEQIKIE IGLRRFLEKG NYNAFTTNFE DLYGMKQLPG LAVQRLNAEG 310 320 330 340 350 360 YGFAGEGDWK TAALDRLLKV MTNNTATGFM EDYTYELSRG NEKALGAHML EVDPTFASDK 370 380 390 400 410 420 PKVIVKPLGI GDKEDPARLI FNGSTGKGVA VSMLDLGTHY RLIINGLTAV KPDEDMPNLP 430 440 450 460 470 480 VAKMVWKPEP NFIEGVKSWI YAGGGHHTVV SLELTVEQVY DWSRMVGLEA VIIDKDTKLR DIIEKTTK

References

[1]

"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001437 Genomic DNA. Translation: AAK79314.1.
PIR	G97065.
RefSeq	NP_347974.1. NC_003030.1.
3D structure databases
ProteinModelPortal	Q97JE0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1117529.
GenomeReviews	Gene locus CA_C1346 in contig AE001437_GR.
KEGG	cac:CA_C1346.
NMPDR	fig|272562.1.peg.1503.
PATRIC	32037075. VBICloAce74127_1551.
Phylogenomic databases
HOGENOM	HBG297198.
OMA	IASESIK.
PhylomeDB	Q97JE0.
ProtClustDB	PRK02929.
Enzyme and pathway databases
BioCyc	CACE272562:CAC1346-MONOMER.
BRENDA	5.3.1.4. 851.
Family and domain databases
HAMAP	MF_00519. Arabinose_Isome. [Tree]
InterPro	IPR024664. Ara_Isoase_C. IPR004216. Fuc/Ara_isomerase_C. IPR009015. Fucose_isomerase_N/cen. IPR003762. Lara_isomerase. [Graphical view]
KO	K01804.
Pfam	PF11762. Arabinose_Iso_C. 1 hit. PF02610. Arabinose_Isome. 1 hit. [Graphical view]
PIRSF	PIRSF001478. L-ara_isomerase. 1 hit.
ProDom	PD018364. Lara_isomerase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50443. Fuc_isomerase_C. 1 hit. SSF53743. Fuc_isomerase_N. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARAA2_CLOAB

Accession

Primary (citable) accession number: Q97JE0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2002
Last sequence update:	October 1, 2001
Last modified:	January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program