Q97IC2 (PKN2_CLOAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable serine/threonine-protein kinase CA_C1728
EC=2.7.11.1

Gene names

Ordered Locus Names:

CA_C1728

Organism

Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787) [Reference proteome] [HAMAP]

Taxonomic identifier

272562 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium › Clostridium acetobutylicum

Protein attributes

Sequence length	657 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 3 PASTA domains. Contains 1 protein kinase domain.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW penicillin binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 657	657	Probable serine/threonine-protein kinase CA_C1728		PRO_0000171194
Regions
	Domain	10 – 274	265	Protein kinase
	Domain	375 – 441	67	PASTA 1
	Domain	443 – 509	67	PASTA 2
	Domain	512 – 577	66	PASTA 3
	Nucleotide binding	16 – 24	9	ATP By similarity
	Compositional bias	587 – 652	66	Asn-rich
Sites
	Active site	143	1	Proton acceptor By similarity
	Binding site	39	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q97IC2 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 0901452EF42E2CA6	FASTA	657	71,115
	10 20 30 40 50 60 MIGTVLSNRY KIEEEIGVGG TAVVYKAMDT LLNRHVAVKV LKHEFTEDEE FVFKFKREAS 70 80 90 100 110 120 AAARIANANI VNIYDVGADG NVNYIVMEYV AGKTLKKLIK ENGKIEFNKI IDYATQIAKA 130 140 150 160 170 180 LNFAHKNGIV HRDIKPHNIM VTDDDIIKVT DFGIAKASNE STITTTNKVV GSAHYLSPEQ 190 200 210 220 230 240 AQGIPVDCRT DIYSFGIVLY EMATGKVPYD ADTPVSIALK HIQDAAVPPN ELNKDIPIAL 250 260 270 280 290 300 NKMILRCIEK KPENRYQNAN EILDELSNVK NNYVNDDEEF TRVMDPAQIQ NESNPNNKLD 310 320 330 340 350 360 NDDTYYNGEP YNKEQPQEEP QEENEEPKNK IKGNNMLSGK AKKALVASII VVLILAGSAL 370 380 390 400 410 420 AFSMGSGIFK PNSNSVSKVK VPKIIGLSES DAKGKVEDAK LKFQVVDRVK SSKPKGTVVT 430 440 450 460 470 480 CYPNEDTEVD SGTVVRVDIS SGDTDQTLPS LVGLPESAAR AQIKQYGCNV GSVTQEYSDD 490 500 510 520 530 540 VAQGNVISQS PSEGSQIKKG MTIDLVISRG PEVKKATVPS VYGKTSDSAS SILQNAGFGV 550 560 570 580 590 600 NVQNKDVTNA DQNGIVIEEY PNGYVNKGTT VTIVIGRFNS TAVQPPNNNN GNGNQNQNQN 610 620 630 640 650 KTPDTNHDDS KAPTGGNNDN QNQNNTTNPN GTQPAGGNVT GTGNGNVTNT PNGTGQK

References

[1]

"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001437 Genomic DNA. Translation: AAK79694.1.
PIR	C97113.
RefSeq	NP_348354.1. NC_003030.1.
3D structure databases
ProteinModelPortal	Q97IC2.
ModBase	Search...
Protein-protein interaction databases
STRING	272562.CA_C1728.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK79694; AAK79694; CA_C1728.
GeneID	1117911.
KEGG	cac:CA_C1728.
PATRIC	32037834. VBICloAce74127_1930.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000037185.
KO	K08884.
OMA	IRTEPGP.
Enzyme and pathway databases
BioCyc	CACE272562:GJIH-1777-MONOMER.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR005543. PASTA. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF03793. PASTA. 3 hits. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00740. PASTA. 3 hits. SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51178. PASTA. 3 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKN2_CLOAB

Accession

Primary (citable) accession number: Q97IC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
Last sequence update:	October 1, 2001
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program