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Protein

Ribosomal RNA small subunit methyltransferase H

Gene

rsmH

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytosine(1402) in 16S rRNA = S-adenosyl-L-homocysteine + N(4)-methylcytosine(1402) in 16S rRNA.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531S-adenosyl-L-methionineUniRule annotation
Binding sitei79 – 791S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
Binding sitei100 – 1001S-adenosyl-L-methionineUniRule annotation
Binding sitei107 – 1071S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciCACE272562:GJIH-2181-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase HUniRule annotation (EC:2.1.1.199UniRule annotation)
Alternative name(s):
16S rRNA m(4)C1402 methyltransferaseUniRule annotation
rRNA (cytosine-N(4)-)-methyltransferase RsmHUniRule annotation
Gene namesi
Name:rsmHUniRule annotation
Synonyms:mraW
Ordered Locus Names:CA_C2132
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Ribosomal RNA small subunit methyltransferase HPRO_0000108610Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C2132.

Structurei

3D structure databases

ProteinModelPortaliQ97H81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 353S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RsmH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049777.
KOiK03438.
OMAiNKKIHPA.
OrthoDBiEOG6X9MQ1.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97H81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFNHVPVLL EETIENLNIK EDGIYVDCTL GGAGHSSEIL KRLSSKGRLI
60 70 80 90 100
GIDQDKDALK AASERLKEYK NLTFVHDNFS NIKNILEELK IDKVDGILAD
110 120 130 140 150
LGVSSYQLDE PERGFSYMND APLDMRMNRD SEFSAYDVIN GYDEEKLYSI
160 170 180 190 200
IKNYGEEKFA KRIAKFIVEK RSEEAINTTF ELVDIIKAAI PAKFRRQGPH
210 220 230 240 250
PAKRTFQAIR IEVNQELEIL NKTIEDSVDK LKSEGRICII TFHSLEDRIV
260 270 280 290 300
KNKYRELQDP CMCPKDIPMC VCGKKPKIKI ITRKPIEASS YELEYNPRSR
310
SAKLRVAEKI NL
Length:312
Mass (Da):35,809
Last modified:October 1, 2001 - v1
Checksum:i79AC3956E551AF49
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK80090.1.
PIRiG97162.
RefSeqiNP_348750.1. NC_003030.1.
WP_010965431.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK80090; AAK80090; CA_C2132.
GeneIDi1118315.
KEGGicac:CA_C2132.
PATRICi32038643. VBICloAce74127_2334.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK80090.1.
PIRiG97162.
RefSeqiNP_348750.1. NC_003030.1.
WP_010965431.1. NC_003030.1.

3D structure databases

ProteinModelPortaliQ97H81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C2132.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK80090; AAK80090; CA_C2132.
GeneIDi1118315.
KEGGicac:CA_C2132.
PATRICi32038643. VBICloAce74127_2334.

Phylogenomic databases

eggNOGiENOG4105CGJ. Bacteria.
COG0275. LUCA.
HOGENOMiHOG000049777.
KOiK03438.
OMAiNKKIHPA.
OrthoDBiEOG6X9MQ1.

Enzyme and pathway databases

BioCyciCACE272562:GJIH-2181-MONOMER.

Family and domain databases

Gene3Di1.10.150.170. 1 hit.
3.40.50.150. 2 hits.
HAMAPiMF_01007. 16SrRNA_methyltr_H.
InterProiIPR002903. RsmH.
IPR023397. SAM-dep_MeTrfase_MraW_recog.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11265. PTHR11265. 1 hit.
PfamiPF01795. Methyltransf_5. 1 hit.
[Graphical view]
PIRSFiPIRSF004486. MraW. 1 hit.
SUPFAMiSSF53335. SSF53335. 2 hits.
SSF81799. SSF81799. 1 hit.
TIGRFAMsiTIGR00006. TIGR00006. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiRSMH_CLOAB
AccessioniPrimary (citable) accession number: Q97H81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2001
Last modified: November 11, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.