Reviewed, UniProtKB/Swiss-Prot Q97FR2 (NTPA_CLOAB)

Names and origin

Protein names

Recommended name:
    Nucleoside-triphosphatase
    EC=3.6.1.15
Alternative name(s):
    Nucleoside triphosphate phosphohydrolase
      Short name=NTPase

Gene names

Ordered Locus Names:

CA_C2665

Organism

Clostridium acetobutylicum [Complete proteome] [HAMAP]

Taxonomic identifier

1488 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions By similarity.
Catalytic activity	NTP + H2O = NDP + phosphate. HAMAP MF_01405
Cofactor	Divalent cations By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the HAM1 NTPase family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	nucleoside-triphosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 201	201	Nucleoside-triphosphatase HAMAP MF_01405		PRO_0000178154

Sequences

	Sequence		Length	Mass (Da)
	Q97FR2-1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: 82DAD8A11F877030	FASTA	201	22,858
	10 20 30 40 50 60 MKKIIIASNN QNKIREIKQI LKEFDFNIVS LKEENIDIDV EEDGKTFIEN AYKKAYEIYK 70 80 90 100 110 120 MRKDCMVIAD DSGLTVDELE GAPGIYSARF AGIHGDDKKN NEKLLSLLEG VPFEKRNAQF 130 140 150 160 170 180 VCSIVLIIDE ANSIKVEGEI SGFITDKEIG TKGFGYDPLF YVPEFKKTFA ELTEDEKNSI 190 200 SHRAIALEKL CSEMKKLNWG E

References

[1]

"Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum." Noelling J., Breton G., Omelchenko M.V., Makarova K.S., Zeng Q., Gibson R., Lee H.M., Dubois J., Qiu D., Hitti J., Wolf Y.I., Tatusov R.L., Sabathe F., Doucette-Stamm L.A., Soucaille P., Daly M.J., Bennett G.N., Koonin E.V., Smith D.R. J. Bacteriol. 183:4823-4838(2001) [PubMed: 11466286] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE001437 Genomic DNA. Translation: AAK80612.1.
PIR	A97228.
RefSeq	NP_349272.1.
3D structure databases
HSSP	HSSP built from PDB template 1B78 based on UniProtKB Q57679.
ModBase	Search...
Genome annotation databases
GeneID	1118848.
GenomeReviews	Gene locus CA_C2665 in contig AE001437_GR.
KEGG	cac:CAC2665.
NMPDR	fig|272562.1.peg.2801.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q97FR2.
OMA	Q97FR2. VYTADWA.
Enzyme and pathway databases
BioCyc	CACE272562:CAC2665-MON.
BRENDA	3.6.1.15. 2866.
Family and domain databases
HAMAP	MF_01405. [Tree]
InterPro	IPR002637. Ham1p-like. [Graphical view]
PANTHER	PTHR11067. Ham1p_like. 1 hit.
Pfam	PF01725. Ham1p_like. 1 hit. [Graphical view]
TIGRFAMs	TIGR00042. Ham1p_like. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NTPA_CLOAB

Accession

Primary (citable) accession number: Q97FR2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	October 1, 2001
Last modified:	June 16, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)