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Protein

Thymidine kinase

Gene

tdk

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei23ATP1
Active sitei89Proton acceptorUniRule annotation1
Binding sitei120Substrate; via amide nitrogenBy similarity1
Metal bindingi145Zinc1
Metal bindingi148Zinc1
Binding sitei179SubstrateBy similarity1
Metal bindingi183Zinc1
Metal bindingi186Zinc1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATP8
Nucleotide bindingi57 – 58ATP2
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.1.21. 1452.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:CA_C2887
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001749671 – 195Thymidine kinaseAdd BLAST195

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C2887.

Structurei

Secondary structure

1195
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 14Combined sources6
Helixi21 – 34Combined sources14
Beta strandi39 – 44Combined sources6
Beta strandi54 – 56Combined sources3
Beta strandi62 – 64Combined sources3
Beta strandi66 – 71Combined sources6
Helixi73 – 77Combined sources5
Beta strandi83 – 87Combined sources5
Helixi90 – 92Combined sources3
Helixi97 – 106Combined sources10
Beta strandi110 – 115Combined sources6
Helixi128 – 134Combined sources7
Beta strandi136 – 140Combined sources5
Turni146 – 148Combined sources3
Beta strandi149 – 152Combined sources4
Beta strandi154 – 159Combined sources6
Beta strandi177 – 182Combined sources6
Turni184 – 186Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XX6X-ray2.00A/B1-191[»]
ProteinModelPortaliQ97F65.
SMRiQ97F65.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97F65.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97F65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYRPKDHGWV EVIVGPMYSG KSEELIRRIR RAKIAKQKIQ VFKPEIDNRY
60 70 80 90 100
SKEDVVSHMG EKEQAVAIKN SREILKYFEE DTEVIAIDEV QFFDDEIVEI
110 120 130 140 150
VNKIAESGRR VICAGLDMDF RGKPFGPIPE LMAIAEFVDK IQAICVVCGN
160 170 180 190
PATRTQRLIN GKPAFYDDPV VLIGAMESYE ARCRKCHVVP QKKEV
Length:195
Mass (Da):22,303
Last modified:October 1, 2001 - v1
Checksum:i6EDB551986B203BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK80830.1.
PIRiC97255.
RefSeqiNP_349490.1. NC_003030.1.
WP_010966171.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK80830; AAK80830; CA_C2887.
GeneIDi1119070.
KEGGicac:CA_C2887.
PATRICi32040185. VBICloAce74127_3071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK80830.1.
PIRiC97255.
RefSeqiNP_349490.1. NC_003030.1.
WP_010966171.1. NC_003030.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XX6X-ray2.00A/B1-191[»]
ProteinModelPortaliQ97F65.
SMRiQ97F65.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C2887.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK80830; AAK80830; CA_C2887.
GeneIDi1119070.
KEGGicac:CA_C2887.
PATRICi32040185. VBICloAce74127_3071.

Phylogenomic databases

eggNOGiENOG4107104. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.

Enzyme and pathway databases

BRENDAi2.7.1.21. 1452.

Miscellaneous databases

EvolutionaryTraceiQ97F65.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKITH_CLOAB
AccessioniPrimary (citable) accession number: Q97F65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.