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Q97F65

- KITH_CLOAB

UniProt

Q97F65 - KITH_CLOAB

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Protein
Thymidine kinase
Gene
tdk, CA_C2887
Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei23 – 231ATP
Active sitei89 – 891Proton acceptor Reviewed prediction
Binding sitei120 – 1201Substrate; via amide nitrogen By similarity
Metal bindingi145 – 1451Zinc
Metal bindingi148 – 1481Zinc
Binding sitei179 – 1791Substrate By similarity
Metal bindingi183 – 1831Zinc
Metal bindingi186 – 1861Zinc

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation
Nucleotide bindingi57 – 582ATPUniRule annotation
Nucleotide bindingi88 – 914ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

DNA synthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciCACE272562:GJIH-2970-MONOMER.
BRENDAi2.7.1.21. 1452.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinase (EC:2.7.1.21)
Gene namesi
Name:tdk
Ordered Locus Names:CA_C2887
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 195195Thymidine kinaseUniRule annotation
PRO_0000174967Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C2887.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 146
Helixi21 – 3414
Beta strandi39 – 446
Beta strandi54 – 563
Beta strandi62 – 643
Beta strandi66 – 716
Helixi73 – 775
Beta strandi83 – 875
Helixi90 – 923
Helixi97 – 10610
Beta strandi110 – 1156
Helixi128 – 1347
Beta strandi136 – 1405
Turni146 – 1483
Beta strandi149 – 1524
Beta strandi154 – 1596
Beta strandi177 – 1826
Turni184 – 1863

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XX6X-ray2.00A/B1-191[»]
ProteinModelPortaliQ97F65.
SMRiQ97F65. Positions 2-191.

Miscellaneous databases

EvolutionaryTraceiQ97F65.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076390.
KOiK00857.
OMAiQAICLSC.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97F65-1 [UniParc]FASTAAdd to Basket

« Hide

MYRPKDHGWV EVIVGPMYSG KSEELIRRIR RAKIAKQKIQ VFKPEIDNRY    50
SKEDVVSHMG EKEQAVAIKN SREILKYFEE DTEVIAIDEV QFFDDEIVEI 100
VNKIAESGRR VICAGLDMDF RGKPFGPIPE LMAIAEFVDK IQAICVVCGN 150
PATRTQRLIN GKPAFYDDPV VLIGAMESYE ARCRKCHVVP QKKEV 195
Length:195
Mass (Da):22,303
Last modified:October 1, 2001 - v1
Checksum:i6EDB551986B203BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001437 Genomic DNA. Translation: AAK80830.1.
PIRiC97255.
RefSeqiNP_349490.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK80830; AAK80830; CA_C2887.
GeneIDi1119070.
KEGGicac:CA_C2887.
PATRICi32040185. VBICloAce74127_3071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001437 Genomic DNA. Translation: AAK80830.1 .
PIRi C97255.
RefSeqi NP_349490.1. NC_003030.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1XX6 X-ray 2.00 A/B 1-191 [» ]
ProteinModelPortali Q97F65.
SMRi Q97F65. Positions 2-191.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272562.CA_C2887.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK80830 ; AAK80830 ; CA_C2887 .
GeneIDi 1119070.
KEGGi cac:CA_C2887.
PATRICi 32040185. VBICloAce74127_3071.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076390.
KOi K00857.
OMAi QAICLSC.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci CACE272562:GJIH-2970-MONOMER.
BRENDAi 2.7.1.21. 1452.

Miscellaneous databases

EvolutionaryTracei Q97F65.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.
  2. "X-ray structure of clostridium acetobutylicum genomics target CAR26."
    Northeast structural genomics consortium (NESG)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-191 IN COMPLEX WITH ZINC IONS AND ADP.

Entry informationi

Entry nameiKITH_CLOAB
AccessioniPrimary (citable) accession number: Q97F65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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