Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

6-phospho-beta-galactosidase

Gene

lacG

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donorUniRule annotation
Active sitei374 – 3741NucleophileUniRule annotation

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BioCyciCACE272562:GJIH-3046-MONOMER.
UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidaseUniRule annotation (EC:3.2.1.85UniRule annotation)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolaseUniRule annotation
Short name:
PGALaseUniRule annotation
P-beta-GalUniRule annotation
Short name:
PBGUniRule annotation
Gene namesi
Name:lacGUniRule annotation
Ordered Locus Names:CA_C2963
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000000814 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4744746-phospho-beta-galactosidasePRO_0000260722Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C2963.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088632.
KOiK01220.
OMAiADGHINR.
OrthoDBiEOG60658J.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97EZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNFGEDFIF GGATAAYQAE GATKEDGKGP CIWDEYLKKE GRFTGDTASD
60 70 80 90 100
FYHKYKEDLK FSRKFGVNGI RISIAWSRVI PDGKGEVNPK GLKFYSDLID
110 120 130 140 150
ECIKNNVEPF VTLHHFDTPL TLFKDGDWLN RNNIDYFVRF AKVCFEALGD
160 170 180 190 200
RVKKWITFNE AWAVAQNGYI IGNFPPSIKY DIPKAAQSMH NMMVAHAKVV
210 220 230 240 250
ELYKSMNLDG EIGIVHTLEG KYPITDSKED KEAAYLDYMI SNKFMLDACF
260 270 280 290 300
KGEYPKETEK TINEIMSKNG GELKIYDGDL EVLKKASSKI DFLGMNYYSS
310 320 330 340 350
HFLKAYEGES RIHHNGTGEK GTSIFALKGI GERVNNPEVP TTDWDWPIYP
360 370 380 390 400
KGLHDMLVRI KNEYPNYKKI YVTENGMGYK DDFKDGKIDD TPRIDYINKH
410 420 430 440 450
LEAILKAKNE GVVVKGYFVW SLMDVLSWSN GYNKRYGLFY VDFKTQNRYA
460 470
KKSAYWFKRI SYEKKLIDFS DIEY
Length:474
Mass (Da):54,672
Last modified:September 30, 2001 - v1
Checksum:i5661CA39AAC5C3BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK80905.1.
PIRiF97264.
RefSeqiNP_349565.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK80905; AAK80905; CA_C2963.
GeneIDi1119146.
KEGGicac:CA_C2963.
PATRICi32040337. VBICloAce74127_3147.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK80905.1.
PIRiF97264.
RefSeqiNP_349565.1. NC_003030.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C2963.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK80905; AAK80905; CA_C2963.
GeneIDi1119146.
KEGGicac:CA_C2963.
PATRICi32040337. VBICloAce74127_3147.

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088632.
KOiK01220.
OMAiADGHINR.
OrthoDBiEOG60658J.

Enzyme and pathway databases

UniPathwayiUPA00542; UER00605.
BioCyciCACE272562:GJIH-3046-MONOMER.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

Entry informationi

Entry nameiLACG_CLOAB
AccessioniPrimary (citable) accession number: Q97EZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 27, 2006
Last sequence update: September 30, 2001
Last modified: March 31, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.