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Q97EB3

- FTHS_CLOAB

UniProt

Q97EB3 - FTHS_CLOAB

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCACE272562:GJIH-3293-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:CA_C3201
    OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
    Taxonomic identifieri272562 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000000814: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_0000199337Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272562.CA_C3201.

    Structurei

    3D structure databases

    ProteinModelPortaliQ97EB3.
    SMRiQ97EB3. Positions 4-554.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q97EB3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTDIEIAQE AKMEPIVKIA EKIGLNEDDI DLYGKYKCKI SLDVLKQNKN    50
    KQDGKLVLVT AINPTPAGEG KSTVTVGLGE ALCKMNKNTV IALREPSLGP 100
    VFGIKGGAAG GGYAQVVPME DINLHFTGDM HAITSANNLL CAAIDNHIHQ 150
    GNSLKIDQRR IVFKRVMDMN DRALRSIVVG LGGKVNGFPR EDGFMITVAS 200
    EIMAILCLAN DLMDLKERMG KILIAYDLDG NPVYCRDLKV EGAMAMLMKD 250
    AMKPNLVQTL ENTPAIIHGG PFANIAHGCN SILATKMALK LGDYVITEAG 300
    FGADLGAEKF LDIKCRYGNL NPDCVVLVAT IRALKHHGGA LKEDLSKPNA 350
    KVLEKGLSNL GKQIENIKKY GVPVVVAINK FITDSEEEIK CIEEYCSKQG 400
    VKVSLTEVWE KGGEGGTDLA NKVLDTLENE KSNFKYLYDE KLSIKEKMDI 450
    IAKEIYGADG VQYTPQANKQ IKEIEKFNLD KLPICVAKTQ YSLSDNPALL 500
    GRPTNFTINV KEVRVSNGAG FVVVQTGNIM TMPGLPKTPA ANKMDIFEDG 550
    SIVGLF 556
    Length:556
    Mass (Da):60,507
    Last modified:October 1, 2001 - v1
    Checksum:i7B0629B679B832FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001437 Genomic DNA. Translation: AAK81137.1.
    PIRiF97293.
    RefSeqiNP_349797.1. NC_003030.1.

    Genome annotation databases

    EnsemblBacteriaiAAK81137; AAK81137; CA_C3201.
    GeneIDi1119383.
    KEGGicac:CA_C3201.
    PATRICi32040821. VBICloAce74127_3380.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001437 Genomic DNA. Translation: AAK81137.1 .
    PIRi F97293.
    RefSeqi NP_349797.1. NC_003030.1.

    3D structure databases

    ProteinModelPortali Q97EB3.
    SMRi Q97EB3. Positions 4-554.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272562.CA_C3201.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK81137 ; AAK81137 ; CA_C3201 .
    GeneIDi 1119383.
    KEGGi cac:CA_C3201.
    PATRICi 32040821. VBICloAce74127_3380.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci CACE272562:GJIH-3293-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787.

    Entry informationi

    Entry nameiFTHS_CLOAB
    AccessioniPrimary (citable) accession number: Q97EB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3