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Protein

Probable 2-phosphosulfolactate phosphatase

Gene

comB

Organism
Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BRENDAi3.1.3.71. 1452.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2-phosphosulfolactate phosphatase (EC:3.1.3.71)
Gene namesi
Name:comB
Ordered Locus Names:CA_C3233
OrganismiClostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)
Taxonomic identifieri272562 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000000814 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814651 – 235Probable 2-phosphosulfolactate phosphataseAdd BLAST235

Interactioni

Protein-protein interaction databases

STRINGi272562.CA_C3233.

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi1 – 6Combined sources6
Helixi9 – 11Combined sources3
Helixi14 – 16Combined sources3
Turni17 – 19Combined sources3
Beta strandi20 – 25Combined sources6
Turni27 – 29Combined sources3
Helixi30 – 39Combined sources10
Beta strandi44 – 47Combined sources4
Helixi51 – 61Combined sources11
Helixi62 – 64Combined sources3
Beta strandi65 – 69Combined sources5
Helixi85 – 87Combined sources3
Helixi90 – 93Combined sources4
Beta strandi97 – 101Combined sources5
Helixi105 – 111Combined sources7
Turni112 – 114Combined sources3
Beta strandi115 – 121Combined sources7
Helixi126 – 136Combined sources11
Beta strandi140 – 144Combined sources5
Helixi153 – 169Combined sources17
Beta strandi173 – 175Combined sources3
Helixi177 – 187Combined sources11
Helixi193 – 196Combined sources4
Helixi200 – 207Combined sources8
Helixi211 – 217Combined sources7
Beta strandi228 – 230Combined sources3
Beta strandi233 – 235Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VR0X-ray2.49A/B/C1-235[»]
ProteinModelPortaliQ97E82.
SMRiQ97E82.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ97E82.

Family & Domainsi

Sequence similaritiesi

Belongs to the ComB family.Curated

Phylogenomic databases

eggNOGiENOG4108N5B. Bacteria.
COG2045. LUCA.
HOGENOMiHOG000232676.
KOiK05979.
OMAiFRATSCM.

Family and domain databases

Gene3Di3.90.1560.10. 1 hit.
HAMAPiMF_00490. ComB. 1 hit.
InterProiIPR005238. ComB-like.
IPR022995. ProB_Pase_ComB.
[Graphical view]
PfamiPF04029. 2-ph_phosp. 1 hit.
[Graphical view]
SUPFAMiSSF142823. SSF142823. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97E82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIDLIISAD DIKEEKVKNK TAVVIDMLRA TSVITTALNN GCKRVVPVLT
60 70 80 90 100
VEEALKKVKE YGKDAILGGE RKGLKIEGFD FSNSPMEYTE DVVKGKTLIM
110 120 130 140 150
TTTNGTRAIK GSETARDILI GSVLNGEAVA EKIVELNNDV VIVNAGTYGE
160 170 180 190 200
FSIDDFICSG YIINCVMDRM KKLELTDAAT TAQYVYKTNE DIKGFVKYAK
210 220 230
HYKRIMELGL KKDFEYCCKK DIVKLVPQYT NGEIL
Length:235
Mass (Da):26,144
Last modified:October 1, 2001 - v1
Checksum:iA8BFB7DF07161EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK81168.1.
PIRiE97297.
RefSeqiNP_349828.1. NC_003030.1.
WP_010966508.1. NC_003030.1.

Genome annotation databases

EnsemblBacteriaiAAK81168; AAK81168; CA_C3233.
GeneIDi1119415.
KEGGicac:CA_C3233.
PATRICi32040893. VBICloAce74127_3411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001437 Genomic DNA. Translation: AAK81168.1.
PIRiE97297.
RefSeqiNP_349828.1. NC_003030.1.
WP_010966508.1. NC_003030.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VR0X-ray2.49A/B/C1-235[»]
ProteinModelPortaliQ97E82.
SMRiQ97E82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272562.CA_C3233.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK81168; AAK81168; CA_C3233.
GeneIDi1119415.
KEGGicac:CA_C3233.
PATRICi32040893. VBICloAce74127_3411.

Phylogenomic databases

eggNOGiENOG4108N5B. Bacteria.
COG2045. LUCA.
HOGENOMiHOG000232676.
KOiK05979.
OMAiFRATSCM.

Enzyme and pathway databases

BRENDAi3.1.3.71. 1452.

Miscellaneous databases

EvolutionaryTraceiQ97E82.

Family and domain databases

Gene3Di3.90.1560.10. 1 hit.
HAMAPiMF_00490. ComB. 1 hit.
InterProiIPR005238. ComB-like.
IPR022995. ProB_Pase_ComB.
[Graphical view]
PfamiPF04029. 2-ph_phosp. 1 hit.
[Graphical view]
SUPFAMiSSF142823. SSF142823. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOMB_CLOAB
AccessioniPrimary (citable) accession number: Q97E82
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2001
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.