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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateUniRule annotation1
Binding sitei32SubstrateUniRule annotation1
Active sitei60Proton donorUniRule annotation1
Binding sitei113SubstrateUniRule annotation1
Binding sitei186Substrate; via amide nitrogenUniRule annotation1
Binding sitei187SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:TV0028
ORF Names:TVG0029151
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001346211 – 219Orotidine 5'-phosphate decarboxylaseAdd BLAST219

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN0028

Structurei

3D structure databases

ProteinModelPortaliQ97CS3
SMRiQ97CS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 67Substrate bindingUniRule annotation10
Regioni163 – 173Substrate bindingUniRule annotationAdd BLAST11

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00081 Archaea
COG0284 LUCA
KOiK01591
OMAiEMSHPGA
OrthoDBiPOG093Z0B4G

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01200_A OMPdecase_type1_A, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR014732 OMPdecase
IPR018089 OMPdecase_AS
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR32119:SF2 PTHR32119:SF2, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR01740 pyrF, 1 hit
PROSITEiView protein in PROSITE
PS00156 OMPDECASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q97CS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKRIIVALD VKEKKKAIDI AESLSDIVFA FKINWPLVLY SSPEVIGEIS
60 70 80 90 100
QYGKVICDFK VADIPYTNSL ITERVRDLGA WGIISHSFLG EESLKSVVNA
110 120 130 140 150
AKGMHVFSVV AMSHPGSDMI NSNAMQLMKL SIECGVYGFV APANKIDDLR
160 170 180 190 200
MIRSATDRVI ISPGIGAQGG DPYTAVLNGS DYLIVGRSVY ESDKPELEVS
210
KLQQTAERAI EDRERLKNS
Length:219
Mass (Da):24,069
Last modified:October 1, 2001 - v1
Checksum:i521C585E62F4B267
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB59170.1

Genome annotation databases

EnsemblBacteriaiBAB59170; BAB59170; BAB59170
KEGGitvo:TVG0029151

Similar proteinsi

Entry informationi

Entry nameiPYRF_THEVO
AccessioniPrimary (citable) accession number: Q97CS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health