ID VATA_THEVO Reviewed; 776 AA. AC Q97CQ0; DT 08-NOV-2002, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2001, sequence version 1. DT 27-MAR-2024, entry version 137. DE RecName: Full=V-type ATP synthase alpha chain; DE EC=7.1.2.2; DE AltName: Full=V-ATPase subunit A; DE Contains: DE RecName: Full=Tvo AtpA intein; DE AltName: Full=Tvo VMA intein; GN Name=atpA; OrderedLocusNames=TV0051; ORFNames=TVG0054274; OS Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC OS 15438 / GSS1). OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales; OC Thermoplasmataceae; Thermoplasma. OX NCBI_TaxID=273116; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1; RX PubMed=11121031; DOI=10.1073/pnas.97.26.14257; RA Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., RA Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., RA Yamamoto Y., Aramaki H., Makino K., Suzuki M.; RT "Archaeal adaptation to higher temperatures revealed by genomic sequence of RT Thermoplasma volcanium."; RL Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000). CC -!- FUNCTION: Produces ATP from ADP in the presence of a proton gradient CC across the membrane. The archaeal alpha chain is a catalytic subunit. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate; CC Xref=Rhea:RHEA:57720, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.1.2.2; CC -!- PTM: This protein undergoes a protein self splicing that involves a CC post-translational excision of the VDE intervening region (intein) CC followed by peptide ligation. {ECO:0000305}. CC -!- MISCELLANEOUS: The intein interrupts the ATP-binding site. CC -!- SIMILARITY: Belongs to the ATPase alpha/beta chains family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000011; BAB59193.1; -; Genomic_DNA. DR RefSeq; WP_010916308.1; NC_002689.2. DR PDB; 4O1S; X-ray; 2.70 A; A/B=234-421. DR PDBsum; 4O1S; -. DR AlphaFoldDB; Q97CQ0; -. DR SMR; Q97CQ0; -. DR STRING; 273116.gene:9380816; -. DR PaxDb; 273116-14324265; -. DR GeneID; 1441538; -. DR KEGG; tvo:TVG0054274; -. DR eggNOG; arCOG00868; Archaea. DR HOGENOM; CLU_008162_1_1_2; -. DR OrthoDB; 115235at2157; -. DR PhylomeDB; Q97CQ0; -. DR Proteomes; UP000001017; Chromosome. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0046933; F:proton-transporting ATP synthase activity, rotational mechanism; IEA:UniProtKB-UniRule. DR GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:UniProtKB-EC. DR GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro. DR GO; GO:0042777; P:proton motive force-driven plasma membrane ATP synthesis; IEA:UniProtKB-UniRule. DR CDD; cd18111; ATP-synt_V_A-type_alpha_C; 1. DR CDD; cd18119; ATP-synt_V_A-type_alpha_N; 1. DR CDD; cd00081; Hint; 1. DR CDD; cd01134; V_A-ATPase_A; 1. DR Gene3D; 2.40.30.20; -; 1. DR Gene3D; 2.40.50.100; -; 1. DR Gene3D; 2.170.16.10; Hedgehog/Intein (Hint) domain; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR HAMAP; MF_00309; ATP_synth_A_arch; 1. DR InterPro; IPR031686; ATP-synth_a_Xtn. DR InterPro; IPR023366; ATP_synth_asu-like_sf. DR InterPro; IPR020003; ATPase_a/bsu_AS. DR InterPro; IPR004100; ATPase_F1/V1/A1_a/bsu_N. DR InterPro; IPR036121; ATPase_F1/V1/A1_a/bsu_N_sf. DR InterPro; IPR000194; ATPase_F1/V1/A1_a/bsu_nucl-bd. DR InterPro; IPR024034; ATPase_F1/V1_b/a_C. DR InterPro; IPR003586; Hint_dom_C. DR InterPro; IPR003587; Hint_dom_N. DR InterPro; IPR036844; Hint_dom_sf. DR InterPro; IPR030934; Intein_C. DR InterPro; IPR006141; Intein_N. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR022878; V-ATPase_asu. DR NCBIfam; TIGR01443; intein_Cterm; 1. DR NCBIfam; TIGR01445; intein_Nterm; 1. DR PANTHER; PTHR43607; V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A; 1. DR PANTHER; PTHR43607:SF1; V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A; 1. DR Pfam; PF00006; ATP-synt_ab; 1. DR Pfam; PF02874; ATP-synt_ab_N; 1. DR Pfam; PF16886; ATP-synt_ab_Xtn; 1. DR Pfam; PF14890; Intein_splicing; 1. DR SMART; SM00305; HintC; 1. DR SMART; SM00306; HintN; 1. DR SUPFAM; SSF47917; C-terminal domain of alpha and beta subunits of F1 ATP synthase; 1. DR SUPFAM; SSF51294; Hedgehog/intein (Hint) domain; 1. DR SUPFAM; SSF50615; N-terminal domain of alpha and beta subunits of F1 ATP synthase; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2. DR PROSITE; PS00152; ATPASE_ALPHA_BETA; 1. DR PROSITE; PS50818; INTEIN_C_TER; 1. DR PROSITE; PS50817; INTEIN_N_TER; 1. PE 1: Evidence at protein level; KW 3D-structure; ATP synthesis; ATP-binding; Autocatalytic cleavage; KW Hydrogen ion transport; Ion transport; Nucleotide-binding; KW Protein splicing; Translocase; Transport. FT CHAIN 1..235 FT /note="V-type ATP synthase alpha chain, 1st part" FT /evidence="ECO:0000255" FT /id="PRO_0000002473" FT CHAIN 236..421 FT /note="Tvo AtpA intein" FT /evidence="ECO:0000255" FT /id="PRO_0000002474" FT CHAIN 422..776 FT /note="V-type ATP synthase alpha chain, 2nd part" FT /evidence="ECO:0000255" FT /id="PRO_0000002475" FT STRAND 242..245 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 250..252 FT /evidence="ECO:0007829|PDB:4O1S" FT HELIX 253..262 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 266..271 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 274..289 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 292..314 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 319..322 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 327..332 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 335..340 FT /evidence="ECO:0007829|PDB:4O1S" FT TURN 341..343 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 349..353 FT /evidence="ECO:0007829|PDB:4O1S" FT TURN 355..357 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 382..401 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 405..407 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 410..412 FT /evidence="ECO:0007829|PDB:4O1S" FT STRAND 417..420 FT /evidence="ECO:0007829|PDB:4O1S" SQ SEQUENCE 776 AA; 86528 MW; 50FBF72E1F5D5C50 CRC64; MGKIVRISGP VVVAEDIENA KMYDVVKVGE MGLIGEIIRI EGNRSTIQVY EDTAGIRPDE KVENTMRPLS VELGPGLLKS IYDGIQRPLD VIKETSGDFI ARGLNPPPLD RKKEWDFVPA VKKNDIVYPG QVIGTVQETS LITHRIIVPD GVSGKIKSIY EGKRTVEDVV CTISTEHGDV DVNLMTTWPV RKARRVVRKL PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGE TPVYLADGKT IKIKDLYSSE RKKEDNIVEA GSGEEIIHLK DPIQIYSYVD GTIVRSRSRL LYKGKSSYLV RIETIGGRSV SVTPVHKLFV LTEKGIEEVM ASNLKVGDMI AAVAESESEA RDCGMSEECV MEAEVYTSLE ATFDRVKSIA YEKGDFDVYD LSVPEYGRNF IGGEGLLVLH NTVIQHQLAK WSDANIVVYI GCGERGNEMT EILTTFPELK DPVSGQPLMD RTVLIANTSN MPVAAREASI YTGITIAEYY RDMGYDVALM ADSTSRWAEA LREISGRLEE MPGEEGYPAY LGRRISEFYE RSGRARLVSP EDRFGSITVI GAVSPPGGDI SEPVSQNTLR VTRVFWALDA SLANRRHFPS INWLNSYSLY TEDLRHWYDE NVAKDWGSLR SQAMDILQRE SELQEVAQLV GYDAMPEKEK SILDVARIIR EDFLQQSAFD EIDSYCSLRK QYLMLKAIME LNSYQSMAID HGVTMDNLSS LPVREKLSRM KIVPEDQVES YYSSIIKEIH KEYTSFIGEK NAEANI //