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Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chain (EC:3.6.3.14)
Alternative name(s):
V-ATPase subunit A
Cleaved into the following chain:
Alternative name(s):
Tvo VMA intein
Gene namesi
Name:atpA
Ordered Locus Names:TV0051
ORF Names:TVG0054274
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000024731 – 235V-type ATP synthase alpha chain, 1st partSequence analysisAdd BLAST235
ChainiPRO_0000002474236 – 421Tvo AtpA inteinSequence analysisAdd BLAST186
ChainiPRO_0000002475422 – 776V-type ATP synthase alpha chain, 2nd partSequence analysisAdd BLAST355

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0052.

Structurei

Secondary structure

1776
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi242 – 245Combined sources4
Beta strandi250 – 252Combined sources3
Helixi253 – 262Combined sources10
Beta strandi266 – 271Combined sources6
Beta strandi274 – 289Combined sources16
Beta strandi292 – 314Combined sources23
Beta strandi319 – 322Combined sources4
Beta strandi327 – 332Combined sources6
Beta strandi335 – 340Combined sources6
Turni341 – 343Combined sources3
Beta strandi349 – 353Combined sources5
Turni355 – 357Combined sources3
Beta strandi381 – 401Combined sources21
Beta strandi405 – 407Combined sources3
Beta strandi410 – 412Combined sources3
Beta strandi417 – 420Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4O1SX-ray2.70A/B234-421[»]
ProteinModelPortaliQ97CQ0.
SMRiQ97CQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiarCOG00868. Archaea.
COG1155. LUCA.
COG1372. LUCA.
KOiK02117.
OMAiFGSGKCV.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
2.170.16.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiIPR031686. ATP-synth_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_bsu_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR030934. Intein_C.
IPR006141. Intein_N.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 2 hits.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
[Graphical view]
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF51294. SSF51294. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q97CQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIVRISGP VVVAEDIENA KMYDVVKVGE MGLIGEIIRI EGNRSTIQVY
60 70 80 90 100
EDTAGIRPDE KVENTMRPLS VELGPGLLKS IYDGIQRPLD VIKETSGDFI
110 120 130 140 150
ARGLNPPPLD RKKEWDFVPA VKKNDIVYPG QVIGTVQETS LITHRIIVPD
160 170 180 190 200
GVSGKIKSIY EGKRTVEDVV CTISTEHGDV DVNLMTTWPV RKARRVVRKL
210 220 230 240 250
PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGE TPVYLADGKT
260 270 280 290 300
IKIKDLYSSE RKKEDNIVEA GSGEEIIHLK DPIQIYSYVD GTIVRSRSRL
310 320 330 340 350
LYKGKSSYLV RIETIGGRSV SVTPVHKLFV LTEKGIEEVM ASNLKVGDMI
360 370 380 390 400
AAVAESESEA RDCGMSEECV MEAEVYTSLE ATFDRVKSIA YEKGDFDVYD
410 420 430 440 450
LSVPEYGRNF IGGEGLLVLH NTVIQHQLAK WSDANIVVYI GCGERGNEMT
460 470 480 490 500
EILTTFPELK DPVSGQPLMD RTVLIANTSN MPVAAREASI YTGITIAEYY
510 520 530 540 550
RDMGYDVALM ADSTSRWAEA LREISGRLEE MPGEEGYPAY LGRRISEFYE
560 570 580 590 600
RSGRARLVSP EDRFGSITVI GAVSPPGGDI SEPVSQNTLR VTRVFWALDA
610 620 630 640 650
SLANRRHFPS INWLNSYSLY TEDLRHWYDE NVAKDWGSLR SQAMDILQRE
660 670 680 690 700
SELQEVAQLV GYDAMPEKEK SILDVARIIR EDFLQQSAFD EIDSYCSLRK
710 720 730 740 750
QYLMLKAIME LNSYQSMAID HGVTMDNLSS LPVREKLSRM KIVPEDQVES
760 770
YYSSIIKEIH KEYTSFIGEK NAEANI
Length:776
Mass (Da):86,528
Last modified:October 1, 2001 - v1
Checksum:i50FBF72E1F5D5C50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59193.1.
RefSeqiWP_010916308.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59193; BAB59193; BAB59193.
GeneIDi1441538.
KEGGitvo:TVG0054274.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59193.1.
RefSeqiWP_010916308.1. NC_002689.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4O1SX-ray2.70A/B234-421[»]
ProteinModelPortaliQ97CQ0.
SMRiQ97CQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273116.TVN0052.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB59193; BAB59193; BAB59193.
GeneIDi1441538.
KEGGitvo:TVG0054274.

Phylogenomic databases

eggNOGiarCOG00868. Archaea.
COG1155. LUCA.
COG1372. LUCA.
KOiK02117.
OMAiFGSGKCV.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
2.170.16.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00309. ATP_synth_A_arch. 1 hit.
InterProiIPR031686. ATP-synth_a_Xtn.
IPR020003. ATPase_a/bsu_AS.
IPR004100. ATPase_F1/V1/A1_a/bsu_N.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR024034. ATPase_F1/V1_bsu_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR030934. Intein_C.
IPR006141. Intein_N.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 2 hits.
PF02874. ATP-synt_ab_N. 1 hit.
PF16886. ATP-synt_ab_Xtn. 1 hit.
[Graphical view]
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF50615. SSF50615. 1 hit.
SSF51294. SSF51294. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVATA_THEVO
AccessioniPrimary (citable) accession number: Q97CQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2001
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The intein interrupts the ATP-binding site.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.