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Q97CQ0

- VATA_THEVO

UniProt

Q97CQ0 - VATA_THEVO

Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

    Catalytic activityi

    ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

    GO - Biological processi

    1. ATP hydrolysis coupled proton transport Source: InterPro
    2. intein-mediated protein splicing Source: InterPro
    3. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    ATP synthesis, Hydrogen ion transport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTVOL273116:GC31-52-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type ATP synthase alpha chain (EC:3.6.3.14)
    Alternative name(s):
    V-ATPase subunit A
    Cleaved into the following chain:
    Alternative name(s):
    Tvo VMA intein
    Gene namesi
    Name:atpA
    Ordered Locus Names:TV0051
    ORF Names:TVG0054274
    OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
    Taxonomic identifieri273116 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001017: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235V-type ATP synthase alpha chain, 1st partSequence AnalysisPRO_0000002473Add
    BLAST
    Chaini236 – 421186Tvo AtpA inteinSequence AnalysisPRO_0000002474Add
    BLAST
    Chaini422 – 776355V-type ATP synthase alpha chain, 2nd partSequence AnalysisPRO_0000002475Add
    BLAST

    Post-translational modificationi

    This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.Curated

    Keywords - PTMi

    Autocatalytic cleavage, Protein splicing

    Interactioni

    Protein-protein interaction databases

    STRINGi273116.TVN0052.

    Structurei

    Secondary structure

    1
    776
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi242 – 2454
    Beta strandi250 – 2523
    Helixi253 – 26210
    Beta strandi266 – 2716
    Beta strandi274 – 28916
    Beta strandi292 – 31423
    Beta strandi319 – 3224
    Beta strandi327 – 3326
    Beta strandi335 – 3406
    Turni341 – 3433
    Beta strandi349 – 3535
    Turni355 – 3573
    Beta strandi381 – 40121
    Beta strandi405 – 4073
    Beta strandi410 – 4123
    Beta strandi417 – 4204

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4O1SX-ray2.70A/B234-421[»]
    ProteinModelPortaliQ97CQ0.
    SMRiQ97CQ0. Positions 422-741.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATPase alpha/beta chains family.Curated

    Phylogenomic databases

    eggNOGiCOG1372.
    KOiK02117.
    OMAiVHNCGER.

    Family and domain databases

    Gene3Di1.10.1140.10. 1 hit.
    2.170.16.10. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPiMF_00309. ATP_synth_A_arch.
    InterProiIPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR022878. V-ATPase_asu.
    [Graphical view]
    PfamiPF00006. ATP-synt_ab. 2 hits.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view]
    SMARTiSM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF51294. SSF51294. 2 hits.
    SSF52540. SSF52540. 2 hits.
    TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
    PS50818. INTEIN_C_TER. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q97CQ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKIVRISGP VVVAEDIENA KMYDVVKVGE MGLIGEIIRI EGNRSTIQVY    50
    EDTAGIRPDE KVENTMRPLS VELGPGLLKS IYDGIQRPLD VIKETSGDFI 100
    ARGLNPPPLD RKKEWDFVPA VKKNDIVYPG QVIGTVQETS LITHRIIVPD 150
    GVSGKIKSIY EGKRTVEDVV CTISTEHGDV DVNLMTTWPV RKARRVVRKL 200
    PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGE TPVYLADGKT 250
    IKIKDLYSSE RKKEDNIVEA GSGEEIIHLK DPIQIYSYVD GTIVRSRSRL 300
    LYKGKSSYLV RIETIGGRSV SVTPVHKLFV LTEKGIEEVM ASNLKVGDMI 350
    AAVAESESEA RDCGMSEECV MEAEVYTSLE ATFDRVKSIA YEKGDFDVYD 400
    LSVPEYGRNF IGGEGLLVLH NTVIQHQLAK WSDANIVVYI GCGERGNEMT 450
    EILTTFPELK DPVSGQPLMD RTVLIANTSN MPVAAREASI YTGITIAEYY 500
    RDMGYDVALM ADSTSRWAEA LREISGRLEE MPGEEGYPAY LGRRISEFYE 550
    RSGRARLVSP EDRFGSITVI GAVSPPGGDI SEPVSQNTLR VTRVFWALDA 600
    SLANRRHFPS INWLNSYSLY TEDLRHWYDE NVAKDWGSLR SQAMDILQRE 650
    SELQEVAQLV GYDAMPEKEK SILDVARIIR EDFLQQSAFD EIDSYCSLRK 700
    QYLMLKAIME LNSYQSMAID HGVTMDNLSS LPVREKLSRM KIVPEDQVES 750
    YYSSIIKEIH KEYTSFIGEK NAEANI 776
    Length:776
    Mass (Da):86,528
    Last modified:October 1, 2001 - v1
    Checksum:i50FBF72E1F5D5C50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB59193.1.
    RefSeqiNP_110571.1. NC_002689.2.

    Genome annotation databases

    EnsemblBacteriaiBAB59193; BAB59193; BAB59193.
    GeneIDi1441538.
    KEGGitvo:TVN0052.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB59193.1 .
    RefSeqi NP_110571.1. NC_002689.2.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4O1S X-ray 2.70 A/B 234-421 [» ]
    ProteinModelPortali Q97CQ0.
    SMRi Q97CQ0. Positions 422-741.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273116.TVN0052.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB59193 ; BAB59193 ; BAB59193 .
    GeneIDi 1441538.
    KEGGi tvo:TVN0052.

    Phylogenomic databases

    eggNOGi COG1372.
    KOi K02117.
    OMAi VHNCGER.

    Enzyme and pathway databases

    BioCyci TVOL273116:GC31-52-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1140.10. 1 hit.
    2.170.16.10. 1 hit.
    3.40.50.300. 2 hits.
    HAMAPi MF_00309. ATP_synth_A_arch.
    InterProi IPR020003. ATPase_a/bsu_AS.
    IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
    IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
    IPR004100. ATPase_F1_a/bsu_N.
    IPR024034. ATPase_F1_bsu/V1_C.
    IPR028992. Hedgehog/Intein_dom.
    IPR003586. Hint_dom_C.
    IPR003587. Hint_dom_N.
    IPR006141. Intein_splice_site.
    IPR027417. P-loop_NTPase.
    IPR022878. V-ATPase_asu.
    [Graphical view ]
    Pfami PF00006. ATP-synt_ab. 2 hits.
    PF00306. ATP-synt_ab_C. 1 hit.
    PF02874. ATP-synt_ab_N. 1 hit.
    [Graphical view ]
    SMARTi SM00305. HintC. 1 hit.
    SM00306. HintN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47917. SSF47917. 1 hit.
    SSF50615. SSF50615. 1 hit.
    SSF51294. SSF51294. 2 hits.
    SSF52540. SSF52540. 2 hits.
    TIGRFAMsi TIGR01443. intein_Cterm. 1 hit.
    TIGR01445. intein_Nterm. 1 hit.
    PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
    PS50818. INTEIN_C_TER. 1 hit.
    PS50817. INTEIN_N_TER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

    Entry informationi

    Entry nameiVATA_THEVO
    AccessioniPrimary (citable) accession number: Q97CQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The intein interrupts the ATP-binding site.

    Keywords - Technical termi

    3D-structure, Complete proteome

    Documents

    1. Intein-containing proteins
      List of intein-containing protein entries
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3