Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q97CQ0

- VATA_THEVO

UniProt

Q97CQ0 - VATA_THEVO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

V-type ATP synthase alpha chain

Gene

atpA

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.

Catalytic activityi

ATP + H2O + H+(In) = ADP + phosphate + H+(Out).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. proton-transporting ATP synthase activity, rotational mechanism Source: UniProtKB-HAMAP

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. intein-mediated protein splicing Source: InterPro
  3. plasma membrane ATP synthesis coupled proton transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

ATP synthesis, Hydrogen ion transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-52-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATP synthase alpha chain (EC:3.6.3.14)
Alternative name(s):
V-ATPase subunit A
Cleaved into the following chain:
Alternative name(s):
Tvo VMA intein
Gene namesi
Name:atpA
Ordered Locus Names:TV0051
ORF Names:TVG0054274
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. proton-transporting two-sector ATPase complex, catalytic domain Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235V-type ATP synthase alpha chain, 1st partSequence AnalysisPRO_0000002473Add
BLAST
Chaini236 – 421186Tvo AtpA inteinSequence AnalysisPRO_0000002474Add
BLAST
Chaini422 – 776355V-type ATP synthase alpha chain, 2nd partSequence AnalysisPRO_0000002475Add
BLAST

Post-translational modificationi

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation.Curated

Keywords - PTMi

Autocatalytic cleavage, Protein splicing

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0052.

Structurei

Secondary structure

1
776
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi242 – 2454Combined sources
Beta strandi250 – 2523Combined sources
Helixi253 – 26210Combined sources
Beta strandi266 – 2716Combined sources
Beta strandi274 – 28916Combined sources
Beta strandi292 – 31423Combined sources
Beta strandi319 – 3224Combined sources
Beta strandi327 – 3326Combined sources
Beta strandi335 – 3406Combined sources
Turni341 – 3433Combined sources
Beta strandi349 – 3535Combined sources
Turni355 – 3573Combined sources
Beta strandi381 – 40121Combined sources
Beta strandi405 – 4073Combined sources
Beta strandi410 – 4123Combined sources
Beta strandi417 – 4204Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4O1SX-ray2.70A/B234-421[»]
ProteinModelPortaliQ97CQ0.
SMRiQ97CQ0. Positions 422-741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.Curated

Phylogenomic databases

eggNOGiCOG1372.
KOiK02117.
OMAiVHNCGER.

Family and domain databases

Gene3Di1.10.1140.10. 1 hit.
2.170.16.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPiMF_00309. ATP_synth_A_arch.
InterProiIPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 2 hits.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTiSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMiSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF51294. SSF51294. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEiPS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q97CQ0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKIVRISGP VVVAEDIENA KMYDVVKVGE MGLIGEIIRI EGNRSTIQVY
60 70 80 90 100
EDTAGIRPDE KVENTMRPLS VELGPGLLKS IYDGIQRPLD VIKETSGDFI
110 120 130 140 150
ARGLNPPPLD RKKEWDFVPA VKKNDIVYPG QVIGTVQETS LITHRIIVPD
160 170 180 190 200
GVSGKIKSIY EGKRTVEDVV CTISTEHGDV DVNLMTTWPV RKARRVVRKL
210 220 230 240 250
PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGE TPVYLADGKT
260 270 280 290 300
IKIKDLYSSE RKKEDNIVEA GSGEEIIHLK DPIQIYSYVD GTIVRSRSRL
310 320 330 340 350
LYKGKSSYLV RIETIGGRSV SVTPVHKLFV LTEKGIEEVM ASNLKVGDMI
360 370 380 390 400
AAVAESESEA RDCGMSEECV MEAEVYTSLE ATFDRVKSIA YEKGDFDVYD
410 420 430 440 450
LSVPEYGRNF IGGEGLLVLH NTVIQHQLAK WSDANIVVYI GCGERGNEMT
460 470 480 490 500
EILTTFPELK DPVSGQPLMD RTVLIANTSN MPVAAREASI YTGITIAEYY
510 520 530 540 550
RDMGYDVALM ADSTSRWAEA LREISGRLEE MPGEEGYPAY LGRRISEFYE
560 570 580 590 600
RSGRARLVSP EDRFGSITVI GAVSPPGGDI SEPVSQNTLR VTRVFWALDA
610 620 630 640 650
SLANRRHFPS INWLNSYSLY TEDLRHWYDE NVAKDWGSLR SQAMDILQRE
660 670 680 690 700
SELQEVAQLV GYDAMPEKEK SILDVARIIR EDFLQQSAFD EIDSYCSLRK
710 720 730 740 750
QYLMLKAIME LNSYQSMAID HGVTMDNLSS LPVREKLSRM KIVPEDQVES
760 770
YYSSIIKEIH KEYTSFIGEK NAEANI
Length:776
Mass (Da):86,528
Last modified:October 1, 2001 - v1
Checksum:i50FBF72E1F5D5C50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59193.1.
RefSeqiNP_110571.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59193; BAB59193; BAB59193.
GeneIDi1441538.
KEGGitvo:TVN0052.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59193.1 .
RefSeqi NP_110571.1. NC_002689.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4O1S X-ray 2.70 A/B 234-421 [» ]
ProteinModelPortali Q97CQ0.
SMRi Q97CQ0. Positions 422-741.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN0052.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB59193 ; BAB59193 ; BAB59193 .
GeneIDi 1441538.
KEGGi tvo:TVN0052.

Phylogenomic databases

eggNOGi COG1372.
KOi K02117.
OMAi VHNCGER.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-52-MONOMER.

Family and domain databases

Gene3Di 1.10.1140.10. 1 hit.
2.170.16.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPi MF_00309. ATP_synth_A_arch.
InterProi IPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR028992. Hedgehog/Intein_dom.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view ]
Pfami PF00006. ATP-synt_ab. 2 hits.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view ]
SMARTi SM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view ]
SUPFAMi SSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF51294. SSF51294. 2 hits.
SSF52540. SSF52540. 2 hits.
TIGRFAMsi TIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEi PS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiVATA_THEVO
AccessioniPrimary (citable) accession number: Q97CQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The intein interrupts the ATP-binding site.

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. Intein-containing proteins
    List of intein-containing protein entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3