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Q97CQ0 (VATA_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
V-type ATP synthase alpha chain

EC=3.6.3.14
Alternative name(s):
V-ATPase subunit A

Cleaved into the following chain:

  1. Tvo AtpA intein
    Alternative name(s):
    Tvo VMA intein
Gene names
Name:atpA
Ordered Locus Names:TV0051
ORF Names:TVG0054274
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length776 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. HAMAP-Rule MF_00309

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP-Rule MF_00309

Post-translational modification

This protein undergoes a protein self splicing that involves a post-translational excision of the VDE intervening region (intein) followed by peptide ligation Potential. HAMAP-Rule MF_00309

Miscellaneous

The intein interrupts the ATP-binding site.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235V-type ATP synthase alpha chain, 1st part Potential
PRO_0000002473
Chain236 – 421186Tvo AtpA intein Potential
PRO_0000002474
Chain422 – 776355V-type ATP synthase alpha chain, 2nd part Potential
PRO_0000002475

Sequences

Sequence LengthMass (Da)Tools
Q97CQ0 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 50FBF72E1F5D5C50

FASTA77686,528
        10         20         30         40         50         60 
MGKIVRISGP VVVAEDIENA KMYDVVKVGE MGLIGEIIRI EGNRSTIQVY EDTAGIRPDE 

        70         80         90        100        110        120 
KVENTMRPLS VELGPGLLKS IYDGIQRPLD VIKETSGDFI ARGLNPPPLD RKKEWDFVPA 

       130        140        150        160        170        180 
VKKNDIVYPG QVIGTVQETS LITHRIIVPD GVSGKIKSIY EGKRTVEDVV CTISTEHGDV 

       190        200        210        220        230        240 
DVNLMTTWPV RKARRVVRKL PPEIPLVTGQ RVIDALFPVA KGGTAAVPGP FGSGKCVSGE 

       250        260        270        280        290        300 
TPVYLADGKT IKIKDLYSSE RKKEDNIVEA GSGEEIIHLK DPIQIYSYVD GTIVRSRSRL 

       310        320        330        340        350        360 
LYKGKSSYLV RIETIGGRSV SVTPVHKLFV LTEKGIEEVM ASNLKVGDMI AAVAESESEA 

       370        380        390        400        410        420 
RDCGMSEECV MEAEVYTSLE ATFDRVKSIA YEKGDFDVYD LSVPEYGRNF IGGEGLLVLH 

       430        440        450        460        470        480 
NTVIQHQLAK WSDANIVVYI GCGERGNEMT EILTTFPELK DPVSGQPLMD RTVLIANTSN 

       490        500        510        520        530        540 
MPVAAREASI YTGITIAEYY RDMGYDVALM ADSTSRWAEA LREISGRLEE MPGEEGYPAY 

       550        560        570        580        590        600 
LGRRISEFYE RSGRARLVSP EDRFGSITVI GAVSPPGGDI SEPVSQNTLR VTRVFWALDA 

       610        620        630        640        650        660 
SLANRRHFPS INWLNSYSLY TEDLRHWYDE NVAKDWGSLR SQAMDILQRE SELQEVAQLV 

       670        680        690        700        710        720 
GYDAMPEKEK SILDVARIIR EDFLQQSAFD EIDSYCSLRK QYLMLKAIME LNSYQSMAID 

       730        740        750        760        770 
HGVTMDNLSS LPVREKLSRM KIVPEDQVES YYSSIIKEIH KEYTSFIGEK NAEANI 

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB59193.1.
RefSeqNP_110571.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ97CQ0.
SMRQ97CQ0. Positions 422-741.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273116.TVN0052.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB59193; BAB59193; BAB59193.
GeneID1441538.
KEGGtvo:TVN0052.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1372.
KOK02117.
OMAVHNCGER.
ProtClustDBCLSK2560425.

Enzyme and pathway databases

BioCycTVOL273116:GC31-52-MONOMER.

Family and domain databases

Gene3D1.10.1140.10. 1 hit.
3.40.50.300. 2 hits.
HAMAPMF_00309. ATP_synth_A_arch.
InterProIPR020003. ATPase_a/bsu_AS.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR024034. ATPase_F1_bsu/V1_C.
IPR003586. Hint_dom_C.
IPR003587. Hint_dom_N.
IPR006141. Intein_splice_site.
IPR027417. P-loop_NTPase.
IPR022878. V-ATPase_asu.
[Graphical view]
PfamPF00006. ATP-synt_ab. 2 hits.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SMARTSM00305. HintC. 1 hit.
SM00306. HintN. 1 hit.
[Graphical view]
SUPFAMSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 2 hits.
TIGRFAMsTIGR01443. intein_Cterm. 1 hit.
TIGR01445. intein_Nterm. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
PS50818. INTEIN_C_TER. 1 hit.
PS50817. INTEIN_N_TER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameVATA_THEVO
AccessionPrimary (citable) accession number: Q97CQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: October 1, 2001
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Intein-containing proteins

List of intein-containing protein entries