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Q97CP1 (OGG1_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

  1. 8-oxoguanine DNA glycosylase
    EC=3.2.2.-
  2. DNA-(apurinic or apyrimidinic site) lyase
    Short name=AP lyase
    EC=4.2.99.18
Gene names
Name:ogg
Ordered Locus Names:TV0060
ORF Names:TVG0063493
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length204 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241

Catalytic activity

The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241

Sequence similarities

Belongs to the type-2 OGG1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 204204Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241
PRO_0000159569

Sites

Active site1291 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97CP1 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: D5CF15B12D55E49D

FASTA20424,267
        10         20         30         40         50         60 
MDFNQYFLPL FQGEASLIIN KKVEEFKLFD RKNKDALFEE LCFCILAANT SARMALDMQN 

        70         80         90        100        110        120 
RIGKGFLYLS ENELREKLKA FKYRFYNVRP RYIVESRDIV DELPYIVSMD NKEEARDLLV 

       130        140        150        160        170        180 
ENVYGFGYKE ASHFLRNVGV FDFAILDKHI LEWLSRYFQV KKNTSRKNYL YNESIFREIA 

       190        200 
KSVGMEPGVL DLYIWYMETG TVIK 

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB59202.1.
RefSeqNP_110581.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ97CP1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273116.TVN0062.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB59202; BAB59202; BAB59202.
GeneID1441548.
KEGGtvo:TVN0062.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1059.
KOK03653.
OMALDLYLWY.

Enzyme and pathway databases

BioCycTVOL273116:GC31-62-MONOMER.

Family and domain databases

HAMAPMF_00241. Ogg.
InterProIPR012092. DNA_glyclase/DNA_lyase_thermo.
IPR011257. DNA_glycosylase.
IPR003265. HhH-GPD_domain.
[Graphical view]
PfamPF00730. HhH-GPD. 1 hit.
[Graphical view]
PIRSFPIRSF005954. Thrmst_ogg. 1 hit.
SMARTSM00478. ENDO3c. 1 hit.
[Graphical view]
SUPFAMSSF48150. SSF48150. 1 hit.
ProtoNetSearch...

Entry information

Entry nameOGG1_THEVO
AccessionPrimary (citable) accession number: Q97CP1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families