Q97CP1 (OGG1_THEVO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

1. 8-oxoguanine DNA glycosylase
   EC=3.2.2.-
2. DNA-(apurinic or apyrimidinic site) lyase
   Short name=AP lyase
   EC=4.2.99.18

Gene names

Name:	ogg
Ordered Locus Names:	TV0060
ORF Names:	TVG0063493

Organism

Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]

Taxonomic identifier

273116 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma › Thermoplasma volcanium

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241
Catalytic activity	The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241
Sequence similarities	Belongs to the type-2 OGG1 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Molecular function	Glycosidase Hydrolase Lyase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	base-excision repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA-(apurinic or apyrimidinic site) lyase activity Inferred from electronic annotation. Source: HAMAP hydrolase activity, hydrolyzing N-glycosyl compounds Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 204	204	Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241		PRO_0000159569
Sites
	Active site	129	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q97CP1 [UniParc]. Last modified October 1, 2001. Version 1. Checksum: D5CF15B12D55E49D	FASTA	204	24,267
	10 20 30 40 50 60 MDFNQYFLPL FQGEASLIIN KKVEEFKLFD RKNKDALFEE LCFCILAANT SARMALDMQN 70 80 90 100 110 120 RIGKGFLYLS ENELREKLKA FKYRFYNVRP RYIVESRDIV DELPYIVSMD NKEEARDLLV 130 140 150 160 170 180 ENVYGFGYKE ASHFLRNVGV FDFAILDKHI LEWLSRYFQV KKNTSRKNYL YNESIFREIA 190 200 KSVGMEPGVL DLYIWYMETG TVIK

References

[1]

"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium." Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M. Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000011 Genomic DNA. Translation: BAB59202.1.
RefSeq	NP_110581.1. NC_002689.2.
3D structure databases
ProteinModelPortal	Q97CP1.
ModBase	Search...
Protein-protein interaction databases
STRING	273116.TVN0062.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAB59202; BAB59202; BAB59202.
GeneID	1441548.
KEGG	tvo:TVN0062.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1059.
KO	K03653.
OMA	IIDRHIL.
ProtClustDB	PRK01229.
Family and domain databases
HAMAP	MF_00241. Ogg.
InterPro	IPR012092. DNA_glyclase/DNA_lyase_thermo. IPR011257. DNA_glycosylase. IPR003265. HhH-GPD_domain. [Graphical view]
PIRSF	PIRSF005954. Thrmst_ogg. 1 hit.
SMART	SM00478. ENDO3c. 1 hit. [Graphical view]
SUPFAM	SSF48150. DNA_glycsylse. 1 hit.
ProtoNet	Search...

Entry information

Entry name

OGG1_THEVO

Accession

Primary (citable) accession number: Q97CP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 1, 2001
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program