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Q97CL3

- FTHS_THEVO

UniProt

Q97CL3 - FTHS_THEVO

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi51 – 588ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTVOL273116:GC31-92-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:TV0088
    ORF Names:TVG0090326
    OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
    Taxonomic identifieri273116 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001017: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536Formate--tetrahydrofolate ligasePRO_0000199416Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273116.TVN0089.

    Structurei

    3D structure databases

    ProteinModelPortaliQ97CL3.
    SMRiQ97CL3. Positions 1-534.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiLKHHGGV.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q97CL3-1 [UniParc]FASTAAdd to Basket

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    MRDIEEILHE MGLSKDDYEL YGRYMAKLSL NLQEVNKKKA KLILVTAMTP    50
    TAAGEGKTTT TIGLGQAFKK LGKNVAIAIR EPSLGPCFGI KGGATGGGKS 100
    KVEPSDRINL LFTGDFPAIS AAHNLLSAMI NNHIYHGNEL NLDPKRITFP 150
    RTIDMNDRSL RSIVVGVGPR DMGAIANDNF VITPASEVMA ITGLSLNYKD 200
    LKEKLSRILA GFTVKNKPVF AADLKAEGSM AALLRDALKP NLVQTTEGVP 250
    AFVHTGPFGN IAHGTSSIVA DRIAMNLFDY VITEAGFGSD LGAEKFFNIV 300
    SRIGNLPINA VVLVATIRAL KLHGGSKKQG EDVEAVKEGS KNLLRHVANI 350
    RKFGVEPVVA LNKFPTDTEN EIMAIGEILD SHGIKWALSE VFEKGGEGGI 400
    ELANKVLSSI GDYQIKRTYE VREDLKTKIE KIAVNVYGAD GVIFEKKALN 450
    DLKKAEEIMN DPYVCMAKTQ YSFSDDASLL NDPHGFKVRV QSVNISSGAG 500
    FVVPILGEIM TMPGLPKRPA AENIDLAEDG EITGLF 536
    Length:536
    Mass (Da):57,913
    Last modified:October 1, 2001 - v1
    Checksum:i5C560811AF6957D8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB59230.1.
    RefSeqiNP_110608.1. NC_002689.2.
    WP_010916345.1. NC_002689.2.

    Genome annotation databases

    EnsemblBacteriaiBAB59230; BAB59230; BAB59230.
    GeneIDi1441575.
    KEGGitvo:TVN0089.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB59230.1 .
    RefSeqi NP_110608.1. NC_002689.2.
    WP_010916345.1. NC_002689.2.

    3D structure databases

    ProteinModelPortali Q97CL3.
    SMRi Q97CL3. Positions 1-534.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273116.TVN0089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB59230 ; BAB59230 ; BAB59230 .
    GeneIDi 1441575.
    KEGGi tvo:TVN0089.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi LKHHGGV.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci TVOL273116:GC31-92-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

    Entry informationi

    Entry nameiFTHS_THEVO
    AccessioniPrimary (citable) accession number: Q97CL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3