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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi51 – 588ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-92-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:TV0088
ORF Names:TVG0090326
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Formate--tetrahydrofolate ligasePRO_0000199416Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0089.

Structurei

3D structure databases

ProteinModelPortaliQ97CL3.
SMRiQ97CL3. Positions 1-534.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiCMVKTHL.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97CL3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRDIEEILHE MGLSKDDYEL YGRYMAKLSL NLQEVNKKKA KLILVTAMTP
60 70 80 90 100
TAAGEGKTTT TIGLGQAFKK LGKNVAIAIR EPSLGPCFGI KGGATGGGKS
110 120 130 140 150
KVEPSDRINL LFTGDFPAIS AAHNLLSAMI NNHIYHGNEL NLDPKRITFP
160 170 180 190 200
RTIDMNDRSL RSIVVGVGPR DMGAIANDNF VITPASEVMA ITGLSLNYKD
210 220 230 240 250
LKEKLSRILA GFTVKNKPVF AADLKAEGSM AALLRDALKP NLVQTTEGVP
260 270 280 290 300
AFVHTGPFGN IAHGTSSIVA DRIAMNLFDY VITEAGFGSD LGAEKFFNIV
310 320 330 340 350
SRIGNLPINA VVLVATIRAL KLHGGSKKQG EDVEAVKEGS KNLLRHVANI
360 370 380 390 400
RKFGVEPVVA LNKFPTDTEN EIMAIGEILD SHGIKWALSE VFEKGGEGGI
410 420 430 440 450
ELANKVLSSI GDYQIKRTYE VREDLKTKIE KIAVNVYGAD GVIFEKKALN
460 470 480 490 500
DLKKAEEIMN DPYVCMAKTQ YSFSDDASLL NDPHGFKVRV QSVNISSGAG
510 520 530
FVVPILGEIM TMPGLPKRPA AENIDLAEDG EITGLF
Length:536
Mass (Da):57,913
Last modified:September 30, 2001 - v1
Checksum:i5C560811AF6957D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59230.1.
RefSeqiNP_110608.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59230; BAB59230; BAB59230.
GeneIDi1441575.
KEGGitvo:TVN0089.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59230.1.
RefSeqiNP_110608.1. NC_002689.2.

3D structure databases

ProteinModelPortaliQ97CL3.
SMRiQ97CL3. Positions 1-534.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273116.TVN0089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB59230; BAB59230; BAB59230.
GeneIDi1441575.
KEGGitvo:TVN0089.

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiCMVKTHL.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciTVOL273116:GC31-92-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiFTHS_THEVO
AccessioniPrimary (citable) accession number: Q97CL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2005
Last sequence update: September 30, 2001
Last modified: March 3, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.