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Q97CL3 (FTHS_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:TV0088
ORF Names:TVG0090326
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length536 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 536536Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199416

Regions

Nucleotide binding51 – 588ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97CL3 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 5C560811AF6957D8

FASTA53657,913
        10         20         30         40         50         60 
MRDIEEILHE MGLSKDDYEL YGRYMAKLSL NLQEVNKKKA KLILVTAMTP TAAGEGKTTT 

        70         80         90        100        110        120 
TIGLGQAFKK LGKNVAIAIR EPSLGPCFGI KGGATGGGKS KVEPSDRINL LFTGDFPAIS 

       130        140        150        160        170        180 
AAHNLLSAMI NNHIYHGNEL NLDPKRITFP RTIDMNDRSL RSIVVGVGPR DMGAIANDNF 

       190        200        210        220        230        240 
VITPASEVMA ITGLSLNYKD LKEKLSRILA GFTVKNKPVF AADLKAEGSM AALLRDALKP 

       250        260        270        280        290        300 
NLVQTTEGVP AFVHTGPFGN IAHGTSSIVA DRIAMNLFDY VITEAGFGSD LGAEKFFNIV 

       310        320        330        340        350        360 
SRIGNLPINA VVLVATIRAL KLHGGSKKQG EDVEAVKEGS KNLLRHVANI RKFGVEPVVA 

       370        380        390        400        410        420 
LNKFPTDTEN EIMAIGEILD SHGIKWALSE VFEKGGEGGI ELANKVLSSI GDYQIKRTYE 

       430        440        450        460        470        480 
VREDLKTKIE KIAVNVYGAD GVIFEKKALN DLKKAEEIMN DPYVCMAKTQ YSFSDDASLL 

       490        500        510        520        530 
NDPHGFKVRV QSVNISSGAG FVVPILGEIM TMPGLPKRPA AENIDLAEDG EITGLF 

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB59230.1.
RefSeqNP_110608.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ97CL3.
SMRQ97CL3. Positions 1-534.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273116.TVN0089.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB59230; BAB59230; BAB59230.
GeneID1441575.
KEGGtvo:TVN0089.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMACGEIMTM.
ProtClustDBCLSK228062.

Enzyme and pathway databases

BioCycTVOL273116:GC31-92-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_THEVO
AccessionPrimary (citable) accession number: Q97CL3
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2001
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways