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Reviewed, UniProtKB/Swiss-Prot Q97C32 (OTCC_THEVO)

Last modified July 28, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ornithine carbamoyltransferase, catabolic
      Short name=OTCase
    EC=2.1.3.3
Gene names
Name: arcB
Ordered Locus Names: TV0273
ORF Names: TVG0283269
OrganismThermoplasma volcanium [Complete proteome] [HAMAP]
Taxonomic identifier50339 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Thermoplasmata › Thermoplasmatales › Thermoplasmataceae › Thermoplasma

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Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109

Pathway

Amino-acid degradation; L-arginine degradation via ADI pathway; carbamoyl phosphate from L-arginine: step 2/2. HAMAP MF_01109

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the ATCase/OTCase family.

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Ontologies

Keywords
   Biological processArginine metabolism
   Cellular componentCytoplasm
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processarginine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentornithine carbamoyltransferase complex

Inferred from electronic annotation. Source: InterPro

   Molecular functionamino acid binding

Inferred from electronic annotation. Source: InterPro

ornithine carbamoyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Ornithine carbamoyltransferase, catabolic HAMAP MF_01109
PRO_0000113080

Regions

Region50 – 545Carbamoyl phosphate binding By similarity
Region262 – 2654Ornithine binding By similarity

Sites

Binding site1011Carbamoyl phosphate By similarity
Binding site1281Carbamoyl phosphate By similarity
Site271Important for structural integrity By similarity
Site1411Important for structural integrity By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q97C32-1 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 8A83160021A71D13

FASTA30534,157
        10         20         30         40         50         60 
MAKRDILSVL DMKNDLDEII NLSIELKKNR YRSYESLRNK MLGLIFEKPS TRTRTSLEVA 

        70         80         90        100        110        120 
IDQLGGHAVY LNPSEMQLGR GETISDTGHV LSRFLDAIAY RAFDHKNVVE LARSTSIPVI 

       130        140        150        160        170        180 
NALDDVEHPL QIVADFMTVK EKKGKFSGLK FSYIGDGNNM ANSLMLGAAI LGVDIYVATP 

       190        200        210        220        230        240 
HGYEPKSEFV DKAKQVAKER GSKVIITNDA IEAAKDADVI YTDVWISMGE ESKRGEKEKA 

       250        260        270        280        290        300 
FTKYQINSDL VSNAKKDYIF MHCLPAHRGL EVTDDVADSI NSVIFDEAEN RLHSEKGVLY 


KLLSY

« Hide

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References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed: 11121031] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / IFO 15438 / JCM 9571 / GSS1.

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Cross-references

Sequence databases

BA000011 Genomic DNA. Translation: BAB59415.1.
RefSeqNP_110791.1.

3D structure databases

HSSPHSSP built from PDB template 1A1S based on UniProtKB Q51742.
ModBaseSearch...

Genome annotation databases

GeneID1440788.
GenomeReviewsGene locus TV0273 in contig BA000011_GR.
NMPDRfig|273116.1.peg.272.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ97C32.

Enzyme and pathway databases

BRENDA2.1.3.3. 256346.

Family and domain databases

HAMAPMF_01109.
[Tree]
InterProIPR006132. Asp/Orn_carbamoyltranf_P_bd.
IPR006130. Asp/Orn_carbamoylTrfase.
IPR006131. Asp_carbamoyltransf_Asp/Orn_bd.
IPR002292. Orn_carbamltrans.
[Graphical view]
PfamPF00185. OTCace. 1 hit.
PF02729. OTCace_N. 1 hit.
[Graphical view]
PRINTSPR00100. AOTCASE.
PR00102. OTCASE.
TIGRFAMsTIGR00658. orni_carb_tr. 1 hit.
PROSITEPS00097. CARBAMOYLTRANSFERASE. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameOTCC_THEVO
AccessionPrimary (citable) accession number: Q97C32
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: October 1, 2001
Last modified: July 28, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents