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Q97C05 (GCSPA_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene names
Name:gcvPA
Ordered Locus Names:TV0300
ORF Names:TVG0309943
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length434 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00712

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00712

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Sequence similarities

Belongs to the GcvP family. N-terminal subunit subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 434434Probable glycine dehydrogenase (decarboxylating) subunit 1 HAMAP-Rule MF_00712
PRO_0000166992

Sequences

Sequence LengthMass (Da)Tools
Q97C05 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: E129009F955B5463

FASTA43447,950
        10         20         30         40         50         60 
MDEISSMLDY LGIKSTEELF SDIPLSVRKK EIGIGSPLDE HLVLERARKY ASLNSTEMLN 

        70         80         90        100        110        120 
FLGNGIYDRV IPEAVNYIIS KSEFLDSYTP YQPEVSQGML QSIFEYQSLI SDLFKMDFTN 

       130        140        150        160        170        180 
ASMYDGYSAL GEAARMAYRI NGKNKILIPE STYDSKLSVL KNYVWGLSMK IEKYKMNEEG 

       190        200        210        220        230        240 
KIDIDDLQSR IDGDTSAVVV ENPNGYGVID ENVFRISEIK KESLLISYVD PISLGVLKPP 

       250        260        270        280        290        300 
GEYGSDIAIA EGQQLGIPMN FGGPLLGIMS FKADYVRKSP GRLIGESVDA DGKRAFVMTL 

       310        320        330        340        350        360 
QTREQHIRRA KATSNICSNQ ALLTLAAGSY LSILGSSGLK KVALLTIKHS KNLAESLGNI 

       370        380        390        400        410        420 
GIEKVFDSIS FSDTLFRIDK NVMLDLAKKG ILGGIKLTSL IKDSKYSSGT FFTATEKTDN 

       430 
EKIKALVNAL EVIM 

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB59442.1.
RefSeqNP_110816.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ97C05.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273116.TVN0297.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB59442; BAB59442; BAB59442.
GeneID1440813.
KEGGtvo:TVN0297.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0403.
KOK00282.
OMASMYDGST.
ProtClustDBPRK00451.

Enzyme and pathway databases

BioCycTVOL273116:GC31-306-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
HAMAPMF_00712. GcvPA.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023010. GDC_P_su1.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFPIRSF006815. GcvPA. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSPA_THEVO
AccessionPrimary (citable) accession number: Q97C05
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2001
Last modified: February 19, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families