Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q97C05

- GCSPA_THEVO

UniProt

Q97C05 - GCSPA_THEVO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciTVOL273116:GC31-306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:TV0300
ORF Names:TVG0309943
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_0000166992Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN0297.

Structurei

3D structure databases

ProteinModelPortaliQ97C05.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
KOiK00282.
OMAiRLVGQTE.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97C05-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEISSMLDY LGIKSTEELF SDIPLSVRKK EIGIGSPLDE HLVLERARKY
60 70 80 90 100
ASLNSTEMLN FLGNGIYDRV IPEAVNYIIS KSEFLDSYTP YQPEVSQGML
110 120 130 140 150
QSIFEYQSLI SDLFKMDFTN ASMYDGYSAL GEAARMAYRI NGKNKILIPE
160 170 180 190 200
STYDSKLSVL KNYVWGLSMK IEKYKMNEEG KIDIDDLQSR IDGDTSAVVV
210 220 230 240 250
ENPNGYGVID ENVFRISEIK KESLLISYVD PISLGVLKPP GEYGSDIAIA
260 270 280 290 300
EGQQLGIPMN FGGPLLGIMS FKADYVRKSP GRLIGESVDA DGKRAFVMTL
310 320 330 340 350
QTREQHIRRA KATSNICSNQ ALLTLAAGSY LSILGSSGLK KVALLTIKHS
360 370 380 390 400
KNLAESLGNI GIEKVFDSIS FSDTLFRIDK NVMLDLAKKG ILGGIKLTSL
410 420 430
IKDSKYSSGT FFTATEKTDN EKIKALVNAL EVIM
Length:434
Mass (Da):47,950
Last modified:October 1, 2001 - v1
Checksum:iE129009F955B5463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59442.1.
RefSeqiNP_110816.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59442; BAB59442; BAB59442.
GeneIDi1440813.
KEGGitvo:TVN0297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59442.1 .
RefSeqi NP_110816.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q97C05.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN0297.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB59442 ; BAB59442 ; BAB59442 .
GeneIDi 1440813.
KEGGi tvo:TVN0297.

Phylogenomic databases

eggNOGi COG0403.
KOi K00282.
OMAi RLVGQTE.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-306-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiGCSPA_THEVO
AccessioniPrimary (citable) accession number: Q97C05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3