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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciTVOL273116:G1G3C-315-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:TV0300
ORF Names:TVG0309943
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669921 – 434Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST434

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN0297

Structurei

3D structure databases

ProteinModelPortaliQ97C05
SMRiQ97C05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00077 Archaea
COG0403 LUCA
KOiK00282
OMAiMYDGASA
OrthoDBiPOG093Z02N9

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q97C05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEISSMLDY LGIKSTEELF SDIPLSVRKK EIGIGSPLDE HLVLERARKY
60 70 80 90 100
ASLNSTEMLN FLGNGIYDRV IPEAVNYIIS KSEFLDSYTP YQPEVSQGML
110 120 130 140 150
QSIFEYQSLI SDLFKMDFTN ASMYDGYSAL GEAARMAYRI NGKNKILIPE
160 170 180 190 200
STYDSKLSVL KNYVWGLSMK IEKYKMNEEG KIDIDDLQSR IDGDTSAVVV
210 220 230 240 250
ENPNGYGVID ENVFRISEIK KESLLISYVD PISLGVLKPP GEYGSDIAIA
260 270 280 290 300
EGQQLGIPMN FGGPLLGIMS FKADYVRKSP GRLIGESVDA DGKRAFVMTL
310 320 330 340 350
QTREQHIRRA KATSNICSNQ ALLTLAAGSY LSILGSSGLK KVALLTIKHS
360 370 380 390 400
KNLAESLGNI GIEKVFDSIS FSDTLFRIDK NVMLDLAKKG ILGGIKLTSL
410 420 430
IKDSKYSSGT FFTATEKTDN EKIKALVNAL EVIM
Length:434
Mass (Da):47,950
Last modified:October 1, 2001 - v1
Checksum:iE129009F955B5463
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB59442.1
RefSeqiWP_010916555.1, NC_002689.2

Genome annotation databases

EnsemblBacteriaiBAB59442; BAB59442; BAB59442
GeneIDi1440813
KEGGitvo:TVG0309943

Similar proteinsi

Entry informationi

Entry nameiGCSPA_THEVO
AccessioniPrimary (citable) accession number: Q97C05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2001
Last modified: April 25, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health