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Q97C05

- GCSPA_THEVO

UniProt

Q97C05 - GCSPA_THEVO

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 1
Gene
gcvPA, TV0300, TVG0309943
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciTVOL273116:GC31-306-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:TV0300
ORF Names:TVG0309943
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 434434Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation
PRO_0000166992Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi273116.TVN0297.

Structurei

3D structure databases

ProteinModelPortaliQ97C05.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
KOiK00282.
OMAiRLVGQTE.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97C05-1 [UniParc]FASTAAdd to Basket

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MDEISSMLDY LGIKSTEELF SDIPLSVRKK EIGIGSPLDE HLVLERARKY    50
ASLNSTEMLN FLGNGIYDRV IPEAVNYIIS KSEFLDSYTP YQPEVSQGML 100
QSIFEYQSLI SDLFKMDFTN ASMYDGYSAL GEAARMAYRI NGKNKILIPE 150
STYDSKLSVL KNYVWGLSMK IEKYKMNEEG KIDIDDLQSR IDGDTSAVVV 200
ENPNGYGVID ENVFRISEIK KESLLISYVD PISLGVLKPP GEYGSDIAIA 250
EGQQLGIPMN FGGPLLGIMS FKADYVRKSP GRLIGESVDA DGKRAFVMTL 300
QTREQHIRRA KATSNICSNQ ALLTLAAGSY LSILGSSGLK KVALLTIKHS 350
KNLAESLGNI GIEKVFDSIS FSDTLFRIDK NVMLDLAKKG ILGGIKLTSL 400
IKDSKYSSGT FFTATEKTDN EKIKALVNAL EVIM 434
Length:434
Mass (Da):47,950
Last modified:October 1, 2001 - v1
Checksum:iE129009F955B5463
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59442.1.
RefSeqiNP_110816.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59442; BAB59442; BAB59442.
GeneIDi1440813.
KEGGitvo:TVN0297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59442.1 .
RefSeqi NP_110816.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q97C05.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273116.TVN0297.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB59442 ; BAB59442 ; BAB59442 .
GeneIDi 1440813.
KEGGi tvo:TVN0297.

Phylogenomic databases

eggNOGi COG0403.
KOi K00282.
OMAi RLVGQTE.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-306-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiGCSPA_THEVO
AccessioniPrimary (citable) accession number: Q97C05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2001
Last modified: September 3, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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