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Q97C04

- GCSPB_THEVO

UniProt

Q97C04 - GCSPB_THEVO

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTVOL273116:GC31-307-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:TV0301
ORF Names:TVG0311358
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN0298.

Structurei

3D structure databases

ProteinModelPortaliQ97C04.
SMRiQ97C04. Positions 31-472.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00283.
OMAiWTGLMMI.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97C04-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFKQAYYEE PIIKDIKSSN TFSLSEQVDE SILPENLKRK DLELPEVSEY
60 70 80 90 100
DVVRHYTRLS QMNYTVDVGI YPLGSCTMKY NPKFADRVSA IDGFRNIHPF
110 120 130 140 150
QPENTVQGAL HVMYDLQEYL KKISDMDAVS LQPMAGADGE FTGILIVKKY
160 170 180 190 200
FEDKGEDRTE IIIPDSAHGT NPASATMGGF DVVEVPSDDK GMVDLEALRA
210 220 230 240 250
AVSKKTAAFM ITNPNTLGIF EQNIEEIAKI IHNAGALLYY DGANLNAIFG
260 270 280 290 300
ITSPGLMGFD IVHFNLHKSF ATPHGGGGPG AGPVAVKSFL KDFLPVPIVD
310 320 330 340 350
FDGNSYRLNY ELKKTIGKVS SFYGSFSILL RAWSYIIRNG DDGLKNVSAR
360 370 380 390 400
AVLNSNYLKK KLEKYYDIPY YPLKKHEFVL STENTGKRAL DIGKYILDNG
410 420 430 440 450
IHSPTVYFPL IVKEAMMIEP TETVSKADLD NYADVLIEAL KLSDEELKSR
460 470
PKNTAVRRID EVKAARDLKL KW
Length:472
Mass (Da):52,790
Last modified:October 1, 2001 - v1
Checksum:i92977275D2E74AE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59443.1.
RefSeqiNP_110817.1. NC_002689.2.
WP_010916556.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59443; BAB59443; BAB59443.
GeneIDi1440814.
KEGGitvo:TVN0298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59443.1 .
RefSeqi NP_110817.1. NC_002689.2.
WP_010916556.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q97C04.
SMRi Q97C04. Positions 31-472.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN0298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB59443 ; BAB59443 ; BAB59443 .
GeneIDi 1440814.
KEGGi tvo:TVN0298.

Phylogenomic databases

eggNOGi COG1003.
KOi K00283.
OMAi WTGLMMI.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-307-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiGCSPB_THEVO
AccessioniPrimary (citable) accession number: Q97C04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2001
Last modified: October 1, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3