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Q97C04

- GCSPB_THEVO

UniProt

Q97C04 - GCSPB_THEVO

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Oct 2001)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciTVOL273116:GC31-307-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:TV0301
    ORF Names:TVG0311358
    OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
    Taxonomic identifieri273116 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
    ProteomesiUP000001017: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 472472Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_0000167034Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei268 – 2681N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi273116.TVN0298.

    Structurei

    3D structure databases

    ProteinModelPortaliQ97C04.
    SMRiQ97C04. Positions 31-472.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00283.
    OMAiWTGLMMI.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q97C04-1 [UniParc]FASTAAdd to Basket

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    MNFKQAYYEE PIIKDIKSSN TFSLSEQVDE SILPENLKRK DLELPEVSEY    50
    DVVRHYTRLS QMNYTVDVGI YPLGSCTMKY NPKFADRVSA IDGFRNIHPF 100
    QPENTVQGAL HVMYDLQEYL KKISDMDAVS LQPMAGADGE FTGILIVKKY 150
    FEDKGEDRTE IIIPDSAHGT NPASATMGGF DVVEVPSDDK GMVDLEALRA 200
    AVSKKTAAFM ITNPNTLGIF EQNIEEIAKI IHNAGALLYY DGANLNAIFG 250
    ITSPGLMGFD IVHFNLHKSF ATPHGGGGPG AGPVAVKSFL KDFLPVPIVD 300
    FDGNSYRLNY ELKKTIGKVS SFYGSFSILL RAWSYIIRNG DDGLKNVSAR 350
    AVLNSNYLKK KLEKYYDIPY YPLKKHEFVL STENTGKRAL DIGKYILDNG 400
    IHSPTVYFPL IVKEAMMIEP TETVSKADLD NYADVLIEAL KLSDEELKSR 450
    PKNTAVRRID EVKAARDLKL KW 472
    Length:472
    Mass (Da):52,790
    Last modified:October 1, 2001 - v1
    Checksum:i92977275D2E74AE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB59443.1.
    RefSeqiNP_110817.1. NC_002689.2.
    WP_010916556.1. NC_002689.2.

    Genome annotation databases

    EnsemblBacteriaiBAB59443; BAB59443; BAB59443.
    GeneIDi1440814.
    KEGGitvo:TVN0298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000011 Genomic DNA. Translation: BAB59443.1 .
    RefSeqi NP_110817.1. NC_002689.2.
    WP_010916556.1. NC_002689.2.

    3D structure databases

    ProteinModelPortali Q97C04.
    SMRi Q97C04. Positions 31-472.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273116.TVN0298.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB59443 ; BAB59443 ; BAB59443 .
    GeneIDi 1440814.
    KEGGi tvo:TVN0298.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00283.
    OMAi WTGLMMI.

    Enzyme and pathway databases

    BioCyci TVOL273116:GC31-307-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

    Entry informationi

    Entry nameiGCSPB_THEVO
    AccessioniPrimary (citable) accession number: Q97C04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2003
    Last sequence update: October 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3