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Q97C04

- GCSPB_THEVO

UniProt

Q97C04 - GCSPB_THEVO

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, TV0301, TVG0311358
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTVOL273116:GC31-307-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:TV0301
ORF Names:TVG0311358
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 472472Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_0000167034Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei268 – 2681N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi273116.TVN0298.

Structurei

3D structure databases

ProteinModelPortaliQ97C04.
SMRiQ97C04. Positions 31-472.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
KOiK00283.
OMAiWTGLMMI.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q97C04-1 [UniParc]FASTAAdd to Basket

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MNFKQAYYEE PIIKDIKSSN TFSLSEQVDE SILPENLKRK DLELPEVSEY    50
DVVRHYTRLS QMNYTVDVGI YPLGSCTMKY NPKFADRVSA IDGFRNIHPF 100
QPENTVQGAL HVMYDLQEYL KKISDMDAVS LQPMAGADGE FTGILIVKKY 150
FEDKGEDRTE IIIPDSAHGT NPASATMGGF DVVEVPSDDK GMVDLEALRA 200
AVSKKTAAFM ITNPNTLGIF EQNIEEIAKI IHNAGALLYY DGANLNAIFG 250
ITSPGLMGFD IVHFNLHKSF ATPHGGGGPG AGPVAVKSFL KDFLPVPIVD 300
FDGNSYRLNY ELKKTIGKVS SFYGSFSILL RAWSYIIRNG DDGLKNVSAR 350
AVLNSNYLKK KLEKYYDIPY YPLKKHEFVL STENTGKRAL DIGKYILDNG 400
IHSPTVYFPL IVKEAMMIEP TETVSKADLD NYADVLIEAL KLSDEELKSR 450
PKNTAVRRID EVKAARDLKL KW 472
Length:472
Mass (Da):52,790
Last modified:October 1, 2001 - v1
Checksum:i92977275D2E74AE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59443.1.
RefSeqiNP_110817.1. NC_002689.2.
WP_010916556.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59443; BAB59443; BAB59443.
GeneIDi1440814.
KEGGitvo:TVN0298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59443.1 .
RefSeqi NP_110817.1. NC_002689.2.
WP_010916556.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q97C04.
SMRi Q97C04. Positions 31-472.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN0298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB59443 ; BAB59443 ; BAB59443 .
GeneIDi 1440814.
KEGGi tvo:TVN0298.

Phylogenomic databases

eggNOGi COG1003.
KOi K00283.
OMAi WTGLMMI.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-307-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiGCSPB_THEVO
AccessioniPrimary (citable) accession number: Q97C04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 1, 2001
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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