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Q97BC6 (PGK_THEVO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:TV0530
ORF Names:TVG0521991
OrganismThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) [Complete proteome] [HAMAP]
Taxonomic identifier273116 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000146074

Regions

Nucleotide binding358 – 3614ATP By similarity
Region22 – 243Substrate binding By similarity
Region60 – 634Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1171Substrate By similarity
Binding site1571Substrate By similarity
Binding site3321ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q97BC6 [UniParc].

Last modified October 1, 2001. Version 1.
Checksum: 403FB7056E6F5849

FASTA40844,891
        10         20         30         40         50         60 
MADFFLMDSF DLAGRTIYLR VDINSPVNPV TGEIMGTDRF RAHVETIRKL RDSKVVIVAH 

        70         80         90        100        110        120 
QSRPGKDDFT SLRQHAQVMS RILNKKVMFV DQLFGSLVNK TVESMNEGDI VMLENARFYS 

       130        140        150        160        170        180 
EEVDLTTLES MENSNIVKGL STLFDYYIID AFAAIHRAQT TLVGFRRIKP NIAGALIEKE 

       190        200        210        220        230        240 
VTMIDRFRHL NESPKIAILG GAKIDDSIAV SENFLKSGFV DKILTGGVVA NAFLWAKGID 

       250        260        270        280        290        300 
IGKKNRDFII KNNGDYEKLI AKCKGLLSEF GDRILVPSDF ILSPSGERVS ANGKIPDDQI 

       310        320        330        340        350        360 
LADIGLDTVV EYSEIIDKAK AIFMNGPMGI YEIEAYSSGT REIFSSVAKS EAFSIAGGGH 

       370        380        390        400 
TLSALDKLGL TNRIDHASTG GGALISYLSG EAMPVLEALK ESKRLFEV 

« Hide

References

[1]"Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium."
Kawashima T., Amano N., Koike H., Makino S., Higuchi S., Kawashima-Ohya Y., Watanabe K., Yamazaki M., Kanehori K., Kawamoto T., Nunoshiba T., Yamamoto Y., Aramaki H., Makino K., Suzuki M.
Proc. Natl. Acad. Sci. U.S.A. 97:14257-14262(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000011 Genomic DNA. Translation: BAB59672.1.
RefSeqNP_111049.1. NC_002689.2.

3D structure databases

ProteinModelPortalQ97BC6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273116.TVN0530.

Proteomic databases

PRIDEQ97BC6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAB59672; BAB59672; BAB59672.
GeneID1441046.
KEGGtvo:TVN0530.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMAAGHPVGK.

Enzyme and pathway databases

BioCycTVOL273116:GC31-550-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGK_THEVO
AccessionPrimary (citable) accession number: Q97BC6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2001
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways