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Q97B25

- GSA_THEVO

UniProt

Q97B25 - GSA_THEVO

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, TV0634, TVG0626624
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTVOL273116:GC31-659-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:TV0634
ORF Names:TVG0626624
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000120493Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei261 – 2611N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0635.

Structurei

3D structure databases

ProteinModelPortaliQ97B25.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
KOiK01845.
OMAiRFMVSGN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97B25-1 [UniParc]FASTAAdd to Basket

« Hide

MSSKELFELA AKLFPMGVNS PVRYFKDYPF YVKEGKGSTI LDVDGNKYID    50
YCLGYGPLIL GHSDPDVTRA VIEQAEKGLL FGEPSENEIK LAEMIKETSK 100
NIEMMRFTNS GTEATMHAIR LARAITGRKL IVKMEGGFHG AHDYSLIKSG 150
SGTLTFGSPS SPGIPDEVAQ TVIVGKYNDE NNIKEIFQKY GDKIAAVITE 200
PIMGNAGVIL PKQGFLEFLR DITQKHGSLL IFDEVITGYR FAFSPFQDIM 250
RIDPDITTMG KIIGGGLPIG LFGGSEEIMK NISPSGNVYE AGTFSGNPMS 300
MAAGYAAMEK LSKQDYSILK KRTQKLVSGI DDILDRKHIT HTIKYYGTMF 350
QVFFADHVNN YDDALKARKE VYFKLFKALS KNGVYLPPSQ YETNFVSFAH 400
SDSDIDATLA AFEKAVAEMD 420
Length:420
Mass (Da):46,457
Last modified:October 1, 2001 - v1
Checksum:i7A763726EBD3E83B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59776.1.
RefSeqiNP_111154.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59776; BAB59776; BAB59776.
GeneIDi1441741.
KEGGitvo:TVN0635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB59776.1 .
RefSeqi NP_111154.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q97B25.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273116.TVN0635.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB59776 ; BAB59776 ; BAB59776 .
GeneIDi 1441741.
KEGGi tvo:TVN0635.

Phylogenomic databases

eggNOGi COG0001.
KOi K01845.
OMAi RFMVSGN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci TVOL273116:GC31-659-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiGSA_THEVO
AccessioniPrimary (citable) accession number: Q97B25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2001
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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