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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei614ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TV0772
ORF Names:TVG0775903
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
Proteomesi
  • UP000001017 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001521491 – 910Leucine--tRNA ligaseAdd BLAST910

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0761

Structurei

3D structure databases

ProteinModelPortaliQ97AN8
SMRiQ97AN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi50 – 60"HIGH" regionAdd BLAST11
Motifi611 – 615"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00809 Archaea
COG0495 LUCA
KOiK01869
OMAiHVTGTPI
OrthoDBiPOG093Z006D

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_A Leu_tRNA_synth_A, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR020791 Leu-tRNA-lgase_arc
IPR004493 Leu-tRNA-synth_Ia_arc/euk
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR11946:SF51 PTHR11946:SF51, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00395 leuS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q97AN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYSRCCGST NSRVIYMNID EKWQNAWERD HVFEPKIDER KKFMITVPWP
60 70 80 90 100
YTNGSLHVGH GRTYTLGDII ARYKRSRNYN VLFPMGFHQS GTPILAFSER
110 120 130 140 150
IRAGDASTIA LYRSYLSEYG EKDIDGWLEK FKDPRNIADY FSNAIINDFK
160 170 180 190 200
HLGYSIDWTR KFTSADEFYQ NVVKWQFHKL NEKGLIKQDK YPILYSIDDD
210 220 230 240 250
NAVGEDDIKD GDTDKVSVEE YTAVFFESNS YSLIAASLRP ETLFGVTNIW
260 270 280 290 300
INPTGEYVKI KIGDKIAVVS KEAVDKLKYQ RNDVSVIGPI SAESIQRKKF
310 320 330 340 350
TTPFGKEVPV YKADFVDTDN GTGVVYSVPS HSVYDFVYYR RKKSGQTPVV
360 370 380 390 400
IEAPLKMPEV EIKFDLNSKE GLDEATKELY KSEFYYGKLV NSGEYTGLTV
410 420 430 440 450
RDAREKIKKD LIGSGKAIIF YETSRKAVTR GGSKVIVAVL PDQWFIDYSA
460 470 480 490 500
DWLKKLSHDM LNRMMIYPEM YRNVMNDAID WLKERPCARR RGLGTKLPFD
510 520 530 540 550
DRWVIESLSD STIYPAVYTT SIQMRKLYEN GKLDENAIER IFDGGEVQND
560 570 580 590 600
EERTARNEFS YWYPVDIRLT AVPHISNHLS FYVMNHAAIF PPEKWPSGLI
610 620 630 640 650
ISGLVVSNGA KISKSKGNVV SLLEITKKYS ADIYRLYVAV QADVSSTMDW
660 670 680 690 700
NENDLSNIVR RFNEFKTIMD SFKPDTSELN FEETWFVSRF AERLKQFMDQ
710 720 730 740 750
MDGFQIRDAY INIFYGTLND LKYAVNRGAS QNRSLASIIA DWLRALMPVI
760 770 780 790 800
SHHAEEYWHR YVSNTYVSIN PFDDNFAEKY ERLAKVYGLS TSEFYQVMDY
810 820 830 840 850
VEHIIQDINN IISVTGIEPK SVEITVANED VIKASREFLS NSVSERSKRY
860 870 880 890 900
LQYLAKRRKD IVVYPFNEID ILRRNSSYIS RQVKADVSIN TGDIINGKIA
910
VPGKPVIHIT
Length:910
Mass (Da):104,994
Last modified:October 1, 2001 - v1
Checksum:iC21870CE07188ED3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA Translation: BAB59914.1

Genome annotation databases

EnsemblBacteriaiBAB59914; BAB59914; BAB59914
KEGGitvo:TVG0775903

Similar proteinsi

Entry informationi

Entry nameiSYL_THEVO
AccessioniPrimary (citable) accession number: Q97AN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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