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Q97AN8

- SYL_THEVO

UniProt

Q97AN8 - SYL_THEVO

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei614 – 6141ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-786-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TV0772
ORF Names:TVG0775903
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 910910Leucine--tRNA ligasePRO_0000152149Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273116.TVN0761.

Structurei

3D structure databases

ProteinModelPortaliQ97AN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 6011"HIGH" regionAdd
BLAST
Motifi611 – 6155"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiQNDEERT.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_A. Leu_tRNA_synth_A.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97AN8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYSRCCGST NSRVIYMNID EKWQNAWERD HVFEPKIDER KKFMITVPWP
60 70 80 90 100
YTNGSLHVGH GRTYTLGDII ARYKRSRNYN VLFPMGFHQS GTPILAFSER
110 120 130 140 150
IRAGDASTIA LYRSYLSEYG EKDIDGWLEK FKDPRNIADY FSNAIINDFK
160 170 180 190 200
HLGYSIDWTR KFTSADEFYQ NVVKWQFHKL NEKGLIKQDK YPILYSIDDD
210 220 230 240 250
NAVGEDDIKD GDTDKVSVEE YTAVFFESNS YSLIAASLRP ETLFGVTNIW
260 270 280 290 300
INPTGEYVKI KIGDKIAVVS KEAVDKLKYQ RNDVSVIGPI SAESIQRKKF
310 320 330 340 350
TTPFGKEVPV YKADFVDTDN GTGVVYSVPS HSVYDFVYYR RKKSGQTPVV
360 370 380 390 400
IEAPLKMPEV EIKFDLNSKE GLDEATKELY KSEFYYGKLV NSGEYTGLTV
410 420 430 440 450
RDAREKIKKD LIGSGKAIIF YETSRKAVTR GGSKVIVAVL PDQWFIDYSA
460 470 480 490 500
DWLKKLSHDM LNRMMIYPEM YRNVMNDAID WLKERPCARR RGLGTKLPFD
510 520 530 540 550
DRWVIESLSD STIYPAVYTT SIQMRKLYEN GKLDENAIER IFDGGEVQND
560 570 580 590 600
EERTARNEFS YWYPVDIRLT AVPHISNHLS FYVMNHAAIF PPEKWPSGLI
610 620 630 640 650
ISGLVVSNGA KISKSKGNVV SLLEITKKYS ADIYRLYVAV QADVSSTMDW
660 670 680 690 700
NENDLSNIVR RFNEFKTIMD SFKPDTSELN FEETWFVSRF AERLKQFMDQ
710 720 730 740 750
MDGFQIRDAY INIFYGTLND LKYAVNRGAS QNRSLASIIA DWLRALMPVI
760 770 780 790 800
SHHAEEYWHR YVSNTYVSIN PFDDNFAEKY ERLAKVYGLS TSEFYQVMDY
810 820 830 840 850
VEHIIQDINN IISVTGIEPK SVEITVANED VIKASREFLS NSVSERSKRY
860 870 880 890 900
LQYLAKRRKD IVVYPFNEID ILRRNSSYIS RQVKADVSIN TGDIINGKIA
910
VPGKPVIHIT
Length:910
Mass (Da):104,994
Last modified:October 1, 2001 - v1
Checksum:iC21870CE07188ED3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59914.1.
RefSeqiNP_111280.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB59914; BAB59914; BAB59914.
GeneIDi1441867.
KEGGitvo:TVN0761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB59914.1 .
RefSeqi NP_111280.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q97AN8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN0761.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB59914 ; BAB59914 ; BAB59914 .
GeneIDi 1441867.
KEGGi tvo:TVN0761.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi QNDEERT.

Enzyme and pathway databases

BioCyci TVOL273116:GC31-786-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_A. Leu_tRNA_synth_A.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR020791. Leu-tRNA-lgase_arc.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00395. leuS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiSYL_THEVO
AccessioniPrimary (citable) accession number: Q97AN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2001
Last modified: November 26, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3