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Q97A55

- ASSY_THEVO

UniProt

Q97A55 - ASSY_THEVO

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Protein
Argininosuccinate synthase
Gene
argG, TV0955, TVG0979194
Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831Citrulline By similarity
Binding sitei113 – 1131ATP; via amide nitrogen By similarity
Binding sitei115 – 1151Aspartate By similarity
Binding sitei119 – 1191Aspartate By similarity
Binding sitei119 – 1191Citrulline By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei123 – 1231Citrulline By similarity
Binding sitei169 – 1691Citrulline By similarity
Binding sitei178 – 1781Citrulline By similarity
Binding sitei253 – 2531Citrulline By similarity
Binding sitei265 – 2651Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-954-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:TV0955
ORF Names:TVG0979194
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Argininosuccinate synthaseUniRule annotation
PRO_0000148689Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN0927.

Structurei

3D structure databases

ProteinModelPortaliQ97A55.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiAPPEEAY.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97A55-1 [UniParc]FASTAAdd to Basket

« Hide

MKELLLLYSG GLDTSVMIKW MNENLGYDVS TLTLDIGNND LKSIREKAEA    50
IGAVETFVED VKQEFSYEYI SKSILANGSY EGYPLSTALA RPLMAKKAVE 100
LAEKHGFEAI AHGSTGRGND QVRFELGIKA LNPSLEMLAP VRDWNMLRSE 150
EIEYAKKNNI IVPSDGKYSV DENLWGRSIE GSEIENMSLP VPEDAYEWLV 200
PPWEAGPGEV IKLEFSNGLP VAINDSDFEL QNLIANLNII GGRNSIGLID 250
HVEDRITGIK SREVYECPAA EIITYAHGYL ESLILNKHEI SIKSFLDSKF 300
SQFVYNGLWY DPAMKPLIAG EEILNSEING SISLKLYKGK IYFNGSKGAN 350
FSYNSNVANY STYEFDQKSS KGFIDIFKND TVYSILARQK AKEEALS 397
Length:397
Mass (Da):44,342
Last modified:February 20, 2007 - v3
Checksum:i2A0DBCDF55AD880F
GO

Sequence cautioni

The sequence BAB60097.1 differs from that shown. Reason: Erroneous termination at position 62. Translated as Lys.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60097.1. Sequence problems.
RefSeqiNP_111446.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60097; BAB60097; BAB60097.
GeneIDi1442033.
KEGGitvo:TVN0927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60097.1 . Sequence problems.
RefSeqi NP_111446.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q97A55.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273116.TVN0927.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB60097 ; BAB60097 ; BAB60097 .
GeneIDi 1442033.
KEGGi tvo:TVN0927.

Phylogenomic databases

eggNOGi COG0137.
KOi K01940.
OMAi APPEEAY.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci TVOL273116:GC31-954-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiASSY_THEVO
AccessioniPrimary (citable) accession number: Q97A55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: February 20, 2007
Last modified: May 14, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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