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Q97A55

- ASSY_THEVO

UniProt

Q97A55 - ASSY_THEVO

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Protein

Argininosuccinate synthase

Gene

argG

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831CitrullineUniRule annotation
Binding sitei113 – 1131ATP; via amide nitrogenUniRule annotation
Binding sitei115 – 1151AspartateUniRule annotation
Binding sitei119 – 1191AspartateUniRule annotation
Binding sitei119 – 1191CitrullineUniRule annotation
Binding sitei120 – 1201AspartateUniRule annotation
Binding sitei123 – 1231CitrullineUniRule annotation
Binding sitei169 – 1691CitrullineUniRule annotation
Binding sitei178 – 1781CitrullineUniRule annotation
Binding sitei253 – 2531CitrullineUniRule annotation
Binding sitei265 – 2651CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATPUniRule annotation

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-954-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:TV0955
ORF Names:TVG0979194
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Argininosuccinate synthasePRO_0000148689Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN0927.

Structurei

3D structure databases

ProteinModelPortaliQ97A55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiAPPEEAY.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97A55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKELLLLYSG GLDTSVMIKW MNENLGYDVS TLTLDIGNND LKSIREKAEA
60 70 80 90 100
IGAVETFVED VKQEFSYEYI SKSILANGSY EGYPLSTALA RPLMAKKAVE
110 120 130 140 150
LAEKHGFEAI AHGSTGRGND QVRFELGIKA LNPSLEMLAP VRDWNMLRSE
160 170 180 190 200
EIEYAKKNNI IVPSDGKYSV DENLWGRSIE GSEIENMSLP VPEDAYEWLV
210 220 230 240 250
PPWEAGPGEV IKLEFSNGLP VAINDSDFEL QNLIANLNII GGRNSIGLID
260 270 280 290 300
HVEDRITGIK SREVYECPAA EIITYAHGYL ESLILNKHEI SIKSFLDSKF
310 320 330 340 350
SQFVYNGLWY DPAMKPLIAG EEILNSEING SISLKLYKGK IYFNGSKGAN
360 370 380 390
FSYNSNVANY STYEFDQKSS KGFIDIFKND TVYSILARQK AKEEALS
Length:397
Mass (Da):44,342
Last modified:February 20, 2007 - v3
Checksum:i2A0DBCDF55AD880F
GO

Sequence cautioni

The sequence BAB60097.1 differs from that shown. Reason: Erroneous termination at position 62. Translated as Lys.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60097.1. Sequence problems.
RefSeqiNP_111446.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60097; BAB60097; BAB60097.
GeneIDi1442033.
KEGGitvo:TVN0927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000011 Genomic DNA. Translation: BAB60097.1 . Sequence problems.
RefSeqi NP_111446.1. NC_002689.2.

3D structure databases

ProteinModelPortali Q97A55.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273116.TVN0927.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB60097 ; BAB60097 ; BAB60097 .
GeneIDi 1442033.
KEGGi tvo:TVN0927.

Phylogenomic databases

eggNOGi COG0137.
KOi K01940.
OMAi APPEEAY.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci TVOL273116:GC31-954-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiASSY_THEVO
AccessioniPrimary (citable) accession number: Q97A55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3