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Protein

Argininosuccinate synthase

Gene

argG

Organism
Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathway: L-arginine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. no protein annotated in this organism
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831CitrullineUniRule annotation
Binding sitei113 – 1131ATP; via amide nitrogenUniRule annotation
Binding sitei115 – 1151AspartateUniRule annotation
Binding sitei119 – 1191AspartateUniRule annotation
Binding sitei119 – 1191CitrullineUniRule annotation
Binding sitei120 – 1201AspartateUniRule annotation
Binding sitei123 – 1231CitrullineUniRule annotation
Binding sitei169 – 1691CitrullineUniRule annotation
Binding sitei178 – 1781CitrullineUniRule annotation
Binding sitei253 – 2531CitrullineUniRule annotation
Binding sitei265 – 2651CitrullineUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 159ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTVOL273116:GC31-954-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
Alternative name(s):
Citrulline--aspartate ligaseUniRule annotation
Gene namesi
Name:argGUniRule annotation
Ordered Locus Names:TV0955
ORF Names:TVG0979194
OrganismiThermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)
Taxonomic identifieri273116 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001017 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 397397Argininosuccinate synthasePRO_0000148689Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi273116.TVN0927.

Structurei

3D structure databases

ProteinModelPortaliQ97A55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiPAREWGM.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q97A55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKELLLLYSG GLDTSVMIKW MNENLGYDVS TLTLDIGNND LKSIREKAEA
60 70 80 90 100
IGAVETFVED VKQEFSYEYI SKSILANGSY EGYPLSTALA RPLMAKKAVE
110 120 130 140 150
LAEKHGFEAI AHGSTGRGND QVRFELGIKA LNPSLEMLAP VRDWNMLRSE
160 170 180 190 200
EIEYAKKNNI IVPSDGKYSV DENLWGRSIE GSEIENMSLP VPEDAYEWLV
210 220 230 240 250
PPWEAGPGEV IKLEFSNGLP VAINDSDFEL QNLIANLNII GGRNSIGLID
260 270 280 290 300
HVEDRITGIK SREVYECPAA EIITYAHGYL ESLILNKHEI SIKSFLDSKF
310 320 330 340 350
SQFVYNGLWY DPAMKPLIAG EEILNSEING SISLKLYKGK IYFNGSKGAN
360 370 380 390
FSYNSNVANY STYEFDQKSS KGFIDIFKND TVYSILARQK AKEEALS
Length:397
Mass (Da):44,342
Last modified:February 20, 2007 - v3
Checksum:i2A0DBCDF55AD880F
GO

Sequence cautioni

The sequence BAB60097.1 differs from that shown. Reason: Erroneous termination at position 62. Translated as Lys.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB60097.1. Sequence problems.
RefSeqiNP_111446.1. NC_002689.2.

Genome annotation databases

EnsemblBacteriaiBAB60097; BAB60097; BAB60097.
GeneIDi1442033.
KEGGitvo:TVN0927.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000011 Genomic DNA. Translation: BAB60097.1. Sequence problems.
RefSeqiNP_111446.1. NC_002689.2.

3D structure databases

ProteinModelPortaliQ97A55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi273116.TVN0927.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB60097; BAB60097; BAB60097.
GeneIDi1442033.
KEGGitvo:TVN0927.

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiPAREWGM.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
BioCyciTVOL273116:GC31-954-MONOMER.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1.

Entry informationi

Entry nameiASSY_THEVO
AccessioniPrimary (citable) accession number: Q97A55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: February 20, 2007
Last modified: January 7, 2015
This is version 81 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.